TG 100713
Based on 2 publication(s) in Google Scholar
TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.21%
- No. CAS: 925705-73-3
- Fòrmula: C12H10N6O
- Peso molecular:254.25
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) TG 100713
More
Actividad biológica
Descripciòn
IC50 & Target
[1]|
PI3Kδ 24 nM (IC50) |
PI3Kγ 50 nM (IC50) |
PI3Kα 165 nM (IC50) |
PI3Kβ 215 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.49 μM
Compound: TG100713
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Anticancer activity against human A549 cells by MTT assay
Anticancer activity against human A549 cells by MTT assay
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10.1039/C3MD00301A |
| HeLa | IC50 |
0.15 μM
Compound: TG100713
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Anticancer activity against human HeLa cells by MTT assay
Anticancer activity against human HeLa cells by MTT assay
|
10.1039/C3MD00301A |
| HepG2 | IC50 |
0.82 μM
Compound: TG100713
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Anticancer activity against human HepG2 cells by MTT assay
Anticancer activity against human HepG2 cells by MTT assay
|
10.1039/C3MD00301A |
| MCF7 | IC50 |
1.03 μM
Compound: TG100713
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Anticancer activity against human MCF7 cells by MTT assay
Anticancer activity against human MCF7 cells by MTT assay
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10.1039/C3MD00301A |
In Vitro
TG100713 (10 μM; 48 or 72 h) strongly inhibits endothelial cell (EC) proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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No. CAS 925705-73-3
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Appearance Solid
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Peso molecular 254.25
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Fòrmula C12H10N6O
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Color Light yellow to khaki
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SMILES
OC1=CC=CC(C2=NC3=C(N)N=C(N)N=C3N=C2)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Molecules
In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against Leishmania donovani and Trypanosoma brucei. [Abstract]2020 Apr 23;25(8):1980. PMID: 32340370 -
Sci Rep
QSAR analysis on a large and diverse set of potent phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using MLR and ANN methods. [Abstract]2022 Apr 12;12(1):6090. PMID: 35414065
Solvente y solubilidad
In Vitro:
DMSO : 6.41 mg/mL (25.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9331 mL | 19.6657 mL | 39.3314 mL | 98.3284 mL |
| 5 mM | 0.7866 mL | 3.9331 mL | 7.8663 mL | 19.6657 mL | |
| 10 mM | 0.3933 mL | 1.9666 mL | 3.9331 mL | 9.8328 mL | |
| 15 mM | 0.2622 mL | 1.3110 mL | 2.6221 mL | 6.5552 mL | |
| 20 mM | 0.1967 mL | 0.9833 mL | 1.9666 mL | 4.9164 mL | |
| 25 mM | 0.1573 mL | 0.7866 mL | 1.5733 mL | 3.9331 mL |
TG 100713 Related Classifications
HY-13514 Related Classifications
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