Tivanisiran
Based on 1 Customer Validation
Tivanisiran (SYL1001) is a small interfering RNA (siRNA) targeting TRPV1 . Tivanisiran induces the degradation of TRPV1 mRNA, thereby inhibiting protein synthesis. Tivanisiran alleviates ocular discomfort and pain, and improves ocular hyperemia and tear quality. Tivanisiran is applicable to research related to dry eye disease.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 97.48%
- No. CAS: 1848224-71-4
- Peso molecular:12068.30 (AS: 5294.6 + SS: 6125.7)
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Almacenamiento:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Actividad biológica
Descripciòn
IC50 & Target
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TRPV1 |
In Vitro
Tivanisiran selectively silences TRPV1 in cell lines expressing TRPV subtypes, with an IC50 of 2.67 nM, and reduces TRPV1 mRNA levels by 50%-60%, with this effect peaking at 24-48 hours post-transfection[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand White Rabbits[1]
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Dosage:multiple doses
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Administration:once daily; 4 consecutive days
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Result:Produced palpebral opening responses similar to the reference standard Capsazepine at all evaluated time-points post-capsaicin challenge.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 1848224-71-4
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Appearance Solid
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Peso molecular 12068.30 (AS: 5294.6 + SS: 6125.7)
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Color White to off-white
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SMILES
[Tivanisiran]
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Synonyms
SYL1001
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Sequence
RNA, (A-A-G-C-G-C-A-U-C-U-U-C-U-A-C-U-U-C-A), complex with RNA (U-G-A-A-G-U-A-G-A-A-G-A-U-G-C-G-C-U-U) (1:1)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvente y solubilidad
In Vitro:
H2O : 100 mg/mL (Need ultrasonic)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL; Clear solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2242 KB)
Referencias
Keywords
- Tivanisiran
- 1848224-71-4
- SYL1001
- SYL 1001
- SYL-1001
- Small Interfering RNA (siRNA)
- TRP Channel
- Transient receptor potential channels
- ocular hyperemia
- TRPV4
- rabbit cell lines
- human cell lines
- Transient Receptor Potential Vanilloid 1
- TRPV1 mRNA
- tear quality
- TRPV1
- capsaicin-induced ocular pain rabbit model
- dry eye disease
- Inhibitor
- inhibitor
- inhibit