Referencia número: HY-153886

Wu-5

1 Cited Publications

Revisión del cliente

Based on 1 publication(s) in Google Scholar

Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis.

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Pureza: 99.01%
No. CAS: 2630378-05-9
Fòrmula: C₁₅H₁₃NO₇S
Peso molecular:351.33

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Wu-5 Chemical Structure

No. CAS: 2630378-05-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis^[1].

IC₅₀ & Target

USP10

Ver todos los productos específicos de isoformas AMPK :

Ver todos los productos específicos de isoformas Deubiquitinase :

In Vitro

Wu-5 (10 μM; 24, 48, 72 h) selectively induces the death of FLT3-ITD-positive AML cells^[1].
Wu-5 (1, 2.5, 5 μM; 24, 48 h) induces apoptosis of FLT3-ITD-positive AML cells in a concentration and time-dependent manner^[1].
Wu-5 (5 μM; 24 h) induces FLT3-ITD degradation by the proteasome pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

U937, HL60, MV4-11, Molm13, and MV4-11-R cells
Concentration:

10 μM
Incubation Time:

24, 48, 72 h
Result:

Significantly inhibited the growth of the FLT3-ITD-positive cells (MV4-11, MV4-11-R and Molm13 cells), but had no or little effect on the proliferation of the FLT3-ITD negative cells (U937 and HL60 cells).

Apoptosis Analysis^[1]

Cell Line:

MV4-11, and Molm13 cells
Concentration:

1, 2.5, 5 μM
Incubation Time:

24, 48 h
Result:

Induced the apoptosis of MV4-11 and Molm13 in a concentration and time-dependent manner.

Western Blot Analysis^[1]

Cell Line:

MV4-11, MV4-11-R, and Molm13 cells
Concentration:

5 μM
Incubation Time:

24 h
Result:

Induced FLT3-ITD degradation.

Chemical Information

No. CAS 2630378-05-9
Appearance Solid
Peso molecular 351.33
Fòrmula C₁₅H₁₃NO₇S
Color Off-white to light yellow
SMILES

O=C(C1=CC=C(C=C1)OC2=C([N+]([O-])=O)C=C(C(OCC)=O)S2)OC
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Microbiol Spectr

The TgAMPK-TgPFKII axis essentially regulates protein lactylation in the zoonotic parasite Toxoplasma gondii. [Abstract]

2025 Mar 4;13(3):e0204424. PMID: 39918324

Solvente y solubilidad

In Vitro:

DMSO : 25 mg/mL (71.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8463 mL

14.2316 mL

28.4633 mL

5 mM

0.5693 mL

2.8463 mL

5.6927 mL

10 mM

0.2846 mL

1.4232 mL

2.8463 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Miao Yu, et al. Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways. Acta Pharmacol Sin. 2021 Apr;42(4):604-612. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8463 mL	14.2316 mL	28.4633 mL	71.1582 mL
	5 mM	0.5693 mL	2.8463 mL	5.6927 mL	14.2316 mL
	10 mM	0.2846 mL	1.4232 mL	2.8463 mL	7.1158 mL
	15 mM	0.1898 mL	0.9488 mL	1.8976 mL	4.7439 mL
	20 mM	0.1423 mL	0.7116 mL	1.4232 mL	3.5579 mL
	25 mM	0.1139 mL	0.5693 mL	1.1385 mL	2.8463 mL
	30 mM	0.0949 mL	0.4744 mL	0.9488 mL	2.3719 mL
	40 mM	0.0712 mL	0.3558 mL	0.7116 mL	1.7790 mL
	50 mM	0.0569 mL	0.2846 mL	0.5693 mL	1.4232 mL
	60 mM	0.0474 mL	0.2372 mL	0.4744 mL	1.1860 mL

Keywords

Wu-5

1 Cited Publications

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Wu-5

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Oxygen Sensing Compound Library

Ubiquitination Compound Library

Glycolysis Compound Library

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Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

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Protease Inhibitor Library

Membrane Protein-targeted Compound Library

Highly Selective Inhibitors Library

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Cell Death Library

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Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Brain Cancer Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Kinase Inhibitor Library

PI3K/Akt/mTOR Compound Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Publications Citing Use of MedChemExpress (MCE) Wu-5

Ver todos los productos específicos de isoformas AMPK

Ver todos los productos específicos de isoformas Deubiquitinase

Actividad biológica

Chemical Information

Publications (1)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Wu-5 Related Classifications

HY-153886 Related Classifications