Hp - haptoglobin Gene

Also Known as HP-1; preHP2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15439

Summary

This gene encodes a plasma glycoprotein called haptoglobin that binds free Hemoglobin. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta subunits that form a disulfide-linked tetrameric protein that plays an important role in the sequestration and clearance of extracorpuscular Hemoglobin. Mice lacking the encoded protein exhibit stunted development of lymphoid organs associated with lower counts of mature T and B cells in the blood and secondary lymphoid compartments. [provided by RefSeq, Aug 2016]

Hp Products (2)

mRNA Protein Name
NM_001329965.1 NP_001316894.1 haptoglobin isoform 2 precursor
NM_017370.2 NP_059066.1 haptoglobin isoform 1 preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
23117660 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

haptoglobin

  • zonulin

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101588 Gefapixant Antagonist 99.93% Yes
HY-17410 Iloperidone Antagonist 99.93% Unkown
HY-101588A Gefapixant citrate Antagonist 99.23% Unkown
HY-17410A Iloperidone hydrochloride Antagonist / Unkown

Clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Phase
HY-101103 HP-β-CD 99.74% Phase 3
HY-136026 Camlipixant Antagonist 99.76% Phase 3
HY-127165 Velnacrine Inhibitor 98.79% Phase 3
HY-W011246 Velnacrine maleate Inhibitor 98.0% Phase 3
HY-15376 Besipirdine Antagonist / Phase 3
HY-123857 JNJ-55308942 Antagonist 99.92% Phase 2
HY-117508 JNJ-54175446 Antagonist 98.84% Phase 2
HY-135427 Quilostigmine Inhibitor / Phase 2
HY-106016 HP 184 Activator / Phase 2
HY-W050088 Isoxepac 99.97% Phase 1
HY-P4669 LM-030 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (67)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114364 UDP-Galactose disodium Agonist 99.73% Unkown
HY-15568 A-317491 Antagonist 98.64% Unkown
HY-151480 HP590 98.02% Unkown
HY-110329 ML179 Agonist 99.73% Unkown
HY-15568A A-317491 sodium salt hydrate Antagonist 99.88% Unkown
HY-154840 4-Thiouridine 5′-triphosphate tetralithium Agonist 87.53% Unkown
HY-E70058 α-1-3,4 Fucosyltransferase, helicobacter pylori 90.00% Unkown
HY-P1397A RVD-Hpα TFA Agonist 98.92% Unkown
HY-114364S UDP-α-D-Galactose-13C disodium 99% Unkown
HY-127165S2 Velnacrine-d4 hydrochloride 98.61% Unkown
HY-121870 Dimethocaine Substrate 99.90% Unkown
HY-146564 R-HP210 98.21% Unkown
HY-146564A HP210 Modulator 98.96% Unkown
HY-P5310 IgA1 Peptide HP 99.89% Unkown
HY-127165S Velnacrine-d3 / Unkown
HY-17410S Iloperidone-d3 Antagonist 98.8% Unkown
HY-105463 Saptomycin D Inhibitor / Unkown
HY-106508 Fendosal Inhibitor 99.82% Unkown
HY-108654 PSB 0474 / Unkown
HY-127165S1 Velnacrine-d3 maleate / Unkown
HY-127165S3 Velnacrine-d4 / Unkown
HY-136092 Androsta-1,4,6-triene-3,17-dione Inhibitor 95.0% Unkown
HY-143576 P2X3 antagonist 37 Antagonist / Unkown
HY-145690 HP1328 Inhibitor / Unkown
HY-145691 HP1142 Inhibitor / Unkown
HY-146561 S-HP210 Modulator 98.12% Unkown
HY-150524 UDP-Galactose Agonist / Unkown
HY-153710 P2X3 antagonist 38 Antagonist / Unkown
HY-156203 MRS4608 Antagonist / Unkown
HY-156220 MRS4654 Inhibitor / Unkown
HY-167855 MRS4833 Antagonist / Unkown
HY-167855S 1’-Epi Gemcitabine hydrochloride-13C,15N2 / Unkown
HY-170598 HP211206 Inhibitor / Unkown
HY-17410S1 Iloperidone-d3 hydrochloride Antagonist / Unkown
HY-175196 P2X7 receptor antagonist-6 Antagonist / Unkown
HY-175729 Cyclin A/B RxL-IN-1 Inhibitor / Unkown
HY-178006 MRS4917 Antagonist / Unkown
HY-178461 LDHA-IN-10 Inhibitor / Unkown
HY-179373 UB-MBX-46 Antagonist / Unkown
HY-179446 HP1-IN-2 Inhibitor / Unkown
HY-B2085 Arsthinenol Inhibitor / Unkown
HY-E70064A Helicobacter pylori alpha-1,3-fucosyltransferase / Unkown
HY-NP0236 Cynomolgus Monkey haptoglobin / Unkown
HY-NP226 Helicobacter pylori protein / Unkown
HY-P10539 Hp1404 Inhibitor / Unkown
HY-P11151 HPA3NT3-A2 Inhibitor / Unkown
HY-P1397 RVD-Hpα Agonist / Unkown
HY-RS03793 DLC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06124 HEPH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06331 HP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06332 HP1BP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06343 HPR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W011246S Velnacrine-d3-1 maleate / Unkown
HY-W050088S Isoxepac-d6 / Unkown
HY-14607 Besipirdine hydrochloride Inhibitor / Unkown
HY-154840A 4-Thiouridine 5′-triphosphate tetrasodium Agonist / Unkown
HY-168117 HP-101 Inhibitor / Unkown
HY-170599 H117 Inhibitor 99.27% Unkown
HY-170600 Boc-Ala(Me)-H117 / Unkown
HY-171951 31hP / Unkown
HY-17410S2 Iloperidone-13C,d3 Antagonist / Unkown
HY-RS16740 Hp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18035 Heph Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19126 Dlc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23177 Hp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W097612 P2X4 antagonist-5 Control 99.14% Unkown
HY-108668 TC-P 262 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hp NCBI NCBI:3240