Kl - klotho Gene

Also Known as alpha-kl

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16591

Summary

Enables Fibroblast Growth Factor binding activity and Fibroblast Growth Factor receptor binding activity. Acts upstream of or within several processes, including calcium ion homeostasis; energy reserve metabolic process; and positive regulation of MAPKKK cascade by Fibroblast Growth Factor receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be integral component of membrane. Is expressed in brain. Used to study hyperphosphatemic familial tumoral calcinosis and pulmonary emphysema. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho). [provided by Alliance of Genome Resources, Apr 2022]

Kl Products (1)

mRNA Protein Name
NM_013823.2 NP_038851.2 klotho precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables fibroblast growth factor binding IPI
IPI: Inferred from physical interaction
17086194 MGI
enables fibroblast growth factor receptor binding IPI
IPI: Inferred from physical interaction
17086194 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16436388 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion homeostasis IGI
IGI: Inferred from genetic interaction
22285620 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
9363890 MGI
acts upstream of or within energy reserve metabolic process IMP
IMP: Inferred from mutant phenotype
11095966 MGI
acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
16436388 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

klotho

  • secreted form of Klotho protein

Recombinant Kl Proteins

Cat. No. Product Name Accession Purity
HY-P72879 CD117/c-Kit Protein, Mouse (HEK293, Fc) P05532-1 (S25-T523) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13204A Biperiden Inhibitor 99.74% Unkown
HY-13204 Biperiden hydrochloride Inhibitor 99.90% Unkown
HY-13204B Biperiden lactate Inhibitor / Unkown
HY-13204R Biperiden hydrochloride (Standard) Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-108468 KL001 99.06% Phase 1
HY-19842 GS-9667 Agonist 98.08% Phase 1
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99544 Tagitanlimab Inhibitor ≥99.0% Phase 3

Pre-clinical Phase

Bioactive Molecules (28)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145597 KL-11743 99.40% Unkown
HY-D0286 Fluorol Yellow 088 ≥98.0% Unkown
HY-148185 T01-1 99.87% Unkown
HY-123972 SEC inhibitor KL-2 Inhibitor 99.49% Unkown
HY-128895 KL1333 99.94% Unkown
HY-122720 SEC inhibitor KL-1 Activator 99.58% Unkown
HY-134194 KL201 98.18% Unkown
HY-119506 KL044 99.50% Unkown
HY-172825 KL4-219A Degrader 99.85% Unkown
HY-164496 KL-50 Inhibitor 99.82% Unkown
HY-159688 Cefditoren 98.14% Unkown
HY-169087 MJBIA9836 99.67% Unkown
HY-121849 KL-1156 Inhibitor / Unkown
HY-128895A KL1333 hydrochloride Modulator / Unkown
HY-13204S Biperiden-d5 hydrochloride Inhibitor / Unkown
HY-134193 KL101 / Unkown
HY-143969S KL140061A-d4 / Unkown
HY-148185S T01-1-d5 / Unkown
HY-155972 CRM1-IN-1 Inhibitor / Unkown
HY-155972A CRM1-IN-2 / Unkown
HY-169086 KL-465 / Unkown
HY-180263 KLHDC2 ligand 4 / Unkown
HY-RS07324 KL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10569 PIP5KL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13204AS Biperiden-d5 Inhibitor / Unkown
HY-174774 Human BMPR1B mRNA / Unkown
HY-RS17481 Kl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23939 Kl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991302 KL-A289 Inhibitor / Unkown
HY-P990184 Anti-Mouse MHC Class II (βchain) Antibody (KL277) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kl NCBI NCBI:9365