Mmp8 - matrix metallopeptidase 8 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17394

About Mmp8

Chromosome 9: 7,558,457-7,568,486 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 111 orthologues, 23 paralogues and is associated with 10 phenotypes. Biased expression in liver E18 (RPKM 19.) and liver E14.5 (RPKM .8).

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades types I, II and III collagens. Mice lacking the encoded protein exhibit abnormalities in the inflammatory responses to various agents. This gene is located in a cluster of Other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]

Mmp8 Products (1)

mRNA Protein Name
NM_008611.4 NP_032637.3 neutrophil collagenase preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IMP
IMP: Inferred from mutant phenotype
25049354 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
25049354 MGI
acts upstream of positive regulation of microglial cell activation IMP
IMP: Inferred from mutant phenotype
25049354 MGI
involved in positive regulation of neuroinflammatory response IMP
IMP: Inferred from mutant phenotype
25049354 MGI
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
25049354 MGI
involved in positive regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
25049354 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp8 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (30 - 85)

Peptidase_M10

Peptidase_M10: pfam00413 (106 - 261)

HX

HX: cd00094 (275 - 463)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 465 a.a.
Protein Preferred Names Protein Names

neutrophil collagenase

  • collagenase-2

  • matrix metalloproteinase-8

Recombinant Mmp8 Proteins

Cat. No. Product Name Accession Purity
HY-P73808 MMP-8 Protein, Mouse (HEK293) O70138 (F21-S465) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73809 MMP-8 Protein, Mouse (CHO, His) O70138 (F21-S465) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78328 MMP-8 Protein, Mouse (HEK293, His) O70138 (F21-S465) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-175275 10-Butyl Ether Minocycline Inhibitor / Phase 3
HY-112160 XL-784 free base Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (31)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148905 p-Aminophenylmercuric acetate Activator 98.32% Unkown
HY-110397 KP-457 Inhibitor 98.88% Unkown
HY-113952 Actinonin 98.37% Unkown
HY-P4931 Mca-KPLGL-Dap(Dnp)-AR-NH2 99.30% Unkown
HY-N1454 Apigenin-7-glucuronide Inhibitor 99.74% Unkown
HY-128133 MMP-8 inhibitor-1 Inhibitor 99.70% Unkown
HY-N1463 Luteolin 7-O-glucuronide Inhibitor 99.98% Unkown
HY-162038 RXP03 Inhibitor 98.82% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-110397G KP-457 (GMP) Inhibitor / Unkown
HY-19485 XL-784 Inhibitor 98.25% Unkown
HY-114091 PF-00356231 hydrochloride Inhibitor 99.52% Unkown
HY-147745 MMP2-IN-2 Inhibitor 98.80% Unkown
HY-110116 SD-2590 hydrochloride Inhibitor 99.4% Unkown
HY-147746 MMP2-IN-3 Inhibitor 99.64% Unkown
HY-RS08555 Mmp8 Mouse Pre-designed siRNA Set A / Unkown
HY-113621B Ageladine A dihydrochloride Inhibitor / Unkown
HY-114091A PF-00356231 Inhibitor / Unkown
HY-114396 BR351 Inhibitor / Unkown
HY-137793 Pro-Leu-Gly-NHOH hydrochloride Inhibitor / Unkown
HY-168605 DH-18 / Unkown
HY-180765 Colchicine-O-CO-Enyl(Me)-Enyl-Enyl(Me)-Enyl-1,3,3-trimethylcyclohex-1-ene Activator / Unkown
HY-182795 Colchicine derivative-1 / Unkown
HY-P10972 GIP (22-51) human / Unkown
HY-P2682 MMP-8/MMP-26 Fluorogenic substrate / Unkown
HY-P3699 TNO003 Substrate / Unkown
HY-RS08554 MMP8 Human Pre-designed siRNA Set A / Unkown
HY-RS08556 Mmp8 Rat Pre-designed siRNA Set A / Unkown
HY-35513 3-Aminobenzene-1,2-diol Inhibitor 98.0% Unkown
HY-43586 BR351 precursor Inhibitor / Unkown
HY-P3699A TNO003 TFA Substrate / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp8 NCBI NCBI:4317