Mpo - myeloperoxidase Gene

Also Known as mKIAA4033

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17523

Summary

Enables peroxidase activity. Acts upstream of or within several processes, including hypochlorous acid biosynthetic process; removal of superoxide radicals; and response to fungus. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MPO (myeloperoxidase). [provided by Alliance of Genome Resources, Apr 2022]

Mpo Products (1)

mRNA Protein Name
NM_010824.2 NP_034954.2 myeloperoxidase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables peroxidase activity IDA
IDA: Inferred from direct assay
10085024 MGI
enables peroxidase activity IMP
IMP: Inferred from mutant phenotype
10085024 MGI
Biological Process GO Annotation Evidence References Source
NOT acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
10085024 MGI
acts upstream of or within defense response to fungus IMP
IMP: Inferred from mutant phenotype
10085024 MGI
acts upstream of or within hydrogen peroxide catabolic process IDA
IDA: Inferred from direct assay
10085024 MGI
acts upstream of or within hydrogen peroxide catabolic process IMP
IMP: Inferred from mutant phenotype
10085024 MGI
acts upstream of or within hypochlorous acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
10085024 MGI
acts upstream of or within removal of superoxide radicals IMP
IMP: Inferred from mutant phenotype
10085024 MGI
acts upstream of or within respiratory burst involved in defense response IMP
IMP: Inferred from mutant phenotype
10085024 MGI
acts upstream of or within response to yeast IMP
IMP: Inferred from mutant phenotype
10085024 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myeloperoxidase

Recombinant Mpo Proteins

Cat. No. Product Name Accession Purity
HY-P70282 Myeloperoxidase/MPO Protein, Mouse (HEK293, His) P11247 (M16-T718) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0679 Lubiprostone 99.09% Yes
HY-B0174 Olsalazine Disodium Inducer 99.82% Unkown
HY-B0174A Olsalazine Inducer 99.83% Unkown

Clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-D3224 HCP / Phase 4
HY-145581 Mitiperstat Inhibitor 99.12% Phase 3
HY-17646 Verdiperstat Inhibitor 99.69% Phase 3
HY-106228 HLF1-11 Inhibitor 99.73% Phase 2
HY-105017 Evodenoson Agonist 99.94% Phase 2
HY-133931 Bimakalim / Phase 2
HY-19205A CMI-392 / Phase 2
HY-111341 AZD5904 Inhibitor 99.93% Phase 1

Pre-clinical Phase

Bioactive Molecules (47)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B0880 4-Aminobenzohydrazide Inhibitor 99.96% Unkown
HY-114360 Taurohyodeoxycholic acid Inhibitor 99.73% Unkown
HY-100873 PF-1355 Inhibitor 99.80% Unkown
HY-N7700A Guluronic acid sodium Inhibitor 98.0% Unkown
HY-N6937 (R,R)-Secoisolariciresinol diglucoside 99.21% Unkown
HY-N6066 Praeruptorin E 99.83% Unkown
HY-125859A Myeloperoxidase, human white blood cells Inhibitor / Unkown
HY-125039 N-Acetyl lysyltyrosylcysteine amide Inhibitor 99.81% Unkown
HY-115486 MPO-IN-28 Inhibitor 98.11% Unkown
HY-W011168 8-Bromo-2'-deoxyguanosine 98.0% Unkown
HY-145197 MPO-IN-3 Inhibitor 99.17% Unkown
HY-N11552 Sorbifolin Inhibitor 99.62% Unkown
HY-N6928 Mogroside III-E Inhibitor 99.30% Unkown
HY-W996116 AZM198 Inhibitor 98.40% Unkown
HY-139915 MPO-IN-1 Inhibitor 98.07% Unkown
HY-N4280 7,8-Dimethoxycoumarin Inhibitor 99.75% Unkown
HY-132132 Neutrophil elastase inhibitor 3 Inhibitor 97.23% Unkown
HY-116188 HX1 99.86% Unkown
HY-N7700 Guluronic acid Inhibitor 98.90% Unkown
HY-108127 NAA-004 Inhibitor / Unkown
HY-115828 APA-APA-MPO dihydrochloride / Unkown
HY-115829 APA-H-MPO hydrochloride / Unkown
HY-126017 Aminopyridine 2 Inhibitor / Unkown
HY-145581S Mitiperstat-d3 Inhibitor / Unkown
HY-146651 MPO-IN-4 Inhibitor / Unkown
HY-147691 MPO-IN-5 Inhibitor / Unkown
HY-147692 COX-2-IN-14 Inhibitor / Unkown
HY-163335 MPO-IN-7 Inhibitor / Unkown
HY-168002 MPO-IN-8 Inhibitor / Unkown
HY-173596 SNT-8370 Inhibitor / Unkown
HY-175985 MPO-IN-9 Inhibitor / Unkown
HY-182060 PDE4B/D-IN-5 / Unkown
HY-183367 Anti-inflammatory agent 115 Inhibitor / Unkown
HY-186046 MPO-IN-10 Inhibitor / Unkown
HY-B0174AS Olsalazine-13C6 Inducer / Unkown
HY-B0174AS2 Olsalazine-d3,15N Inducer / Unkown
HY-B0174AS3 Olsalazine-d6 / Unkown
HY-N6937S1 (R,R)-Secoisolariciresinol diglucoside-d6 / Unkown
HY-N8529 Eupalestin Inhibitor / Unkown
HY-RS08621 MPO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W767399 8-Bromo-2'-deoxyguanosine-13C,15N2 / Unkown
HY-103388 NCX 466 Inhibitor / Unkown
HY-163332 MPO-IN-6 Inhibitor / Unkown
HY-19205B (2S,5S)-CMI-392 / Unkown
HY-B0679S Lubiprostone-d7 / Unkown
HY-RS16618 Mpo Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23053 Mpo Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990181 Anti-Mouse myeloperoxidase/MPO Antibody (6G4) Inhibitor 97.00% Unkown
HY-P990812 Anti-Mouse myeloperoxidase/MPO Antibody (6D1) Inhibitor 99.71% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mpo NCBI NCBI:4353