Rac1 - Rac family small GTPase 1 Gene

Also Known as D5Ertd559e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19353

Summary

Enables GTP binding activity; GTP-dependent protein binding activity; and GTPase activity. Involved in several processes, including engulfment of apoptotic cell; nervous system development; and regulation of cell migration. Acts upstream of or within several processes, including cell morphogenesis involved in differentiation; cochlea morphogenesis; and neuron differentiation. Located in several cellular components, including kinocilium; pericentriolar material; and ruffle membrane. Is extrinsic component of plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; embryo mesoderm; eye; and genitourinary system. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 48; colon adenocarcinoma; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]

Rac1 Products (2)

mRNA Protein Name
NM_001347530.1 NP_001334459.1 ras-related C3 botulinum toxin substrate 1 isoform 1
NM_009007.2 NP_033033.1 ras-related C3 botulinum toxin substrate 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein activity IDA
IDA: Inferred from direct assay
17058265 MGI
enables GTP binding IDA
IDA: Inferred from direct assay
12783890 MGI
enables GTP-dependent protein binding IPI
IPI: Inferred from physical interaction
10954424 MGI
enables GTPase activity IDA
IDA: Inferred from direct assay
10699171 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8464478 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
21178006 MGI
involved in Rac protein signal transduction IGI
IGI: Inferred from genetic interaction
14622576 MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IGI
IGI: Inferred from genetic interaction
18953410 MGI
acts upstream of or within actin filament polymerization IDA
IDA: Inferred from direct assay
22750946 MGI
acts upstream of or within anatomical structure arrangement IMP
IMP: Inferred from mutant phenotype
20016102 MGI
acts upstream of or within angiotensin-activated signaling pathway involved in heart process IDA
IDA: Inferred from direct assay
26975711 MGI
acts upstream of or within auditory receptor cell morphogenesis IMP
IMP: Inferred from mutant phenotype
20016102 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
17409253 MGI
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
14657280 MGI
acts upstream of or within cell migration IDA
IDA: Inferred from direct assay
15728191 MGI
acts upstream of or within cell-cell junction organization IMP
IMP: Inferred from mutant phenotype
20016102 MGI
acts upstream of or within cerebral cortex GABAergic interneuron development IGI
IGI: Inferred from genetic interaction
23258346 MGI
acts upstream of or within cerebral cortex radially oriented cell migration IMP
IMP: Inferred from mutant phenotype
17409253 MGI
acts upstream of or within cochlea morphogenesis IMP
IMP: Inferred from mutant phenotype
20016102 MGI
acts upstream of or within cytoskeleton organization IDA
IDA: Inferred from direct assay
14657280 MGI
acts upstream of or within dendrite development IDA
IDA: Inferred from direct assay
12213441 MGI
acts upstream of or within dendrite morphogenesis IGI
IGI: Inferred from genetic interaction
20335472 MGI
acts upstream of or within dopaminergic neuron differentiation IGI
IGI: Inferred from genetic interaction
18953410 MGI
acts upstream of or within embryonic olfactory bulb interneuron precursor migration IMP
IMP: Inferred from mutant phenotype
17409253 MGI
acts upstream of or within endocytosis IDA
IDA: Inferred from direct assay
12446704 MGI
involved in engulfment of apoptotic cell IDA
IDA: Inferred from direct assay
20691665 MGI
involved in enzyme-linked receptor protein signaling pathway IGI
IGI: Inferred from genetic interaction
14622576 MGI
acts upstream of or within epithelial cell morphogenesis IMP
IMP: Inferred from mutant phenotype
20016102 MGI
acts upstream of or within erythrocyte enucleation IMP
IMP: Inferred from mutant phenotype
18264091 MGI
involved in forebrain development IDA
IDA: Inferred from direct assay
19007770 MGI
acts upstream of or within homeostasis of number of cells within a tissue IGI
IGI: Inferred from genetic interaction
23258346 MGI
acts upstream of or within hyperosmotic response IDA
IDA: Inferred from direct assay
12783890 MGI
acts upstream of or within interneuron migration IMP
IMP: Inferred from mutant phenotype
17409253 MGI
acts upstream of or within lamellipodium assembly IDA
IDA: Inferred from direct assay
15728191 MGI
involved in midbrain dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
18953410 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
17409253 MGI
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
22959435 MGI
involved in neuron projection morphogenesis IGI
IGI: Inferred from genetic interaction
21483795 MGI
involved in non-canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
21483795 MGI
involved in phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
10934045 MGI
acts upstream of or within positive regulation of actin filament polymerization IDA
IDA: Inferred from direct assay
12853475 MGI
acts upstream of or within positive regulation of dendritic spine development IGI
IGI: Inferred from genetic interaction
25865668 MGI
acts upstream of or within positive regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
25865668 MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
23412604 MGI
involved in positive regulation of neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
19625648 MGI
involved in positive regulation of ovarian follicle development IMP
IMP: Inferred from mutant phenotype
27050391 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
15728722 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IGI
IGI: Inferred from genetic interaction
14622576 MGI
acts upstream of or within protein localization to plasma membrane IDA
IDA: Inferred from direct assay
23184663 MGI
acts upstream of or within regulation of ERK5 cascade IDA
IDA: Inferred from direct assay
26975711 MGI
involved in regulation of cell adhesion involved in heart morphogenesis IMP
IMP: Inferred from mutant phenotype
25514037 MGI
acts upstream of or within regulation of cell morphogenesis IGI
IGI: Inferred from genetic interaction
23258346 MGI
involved in regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
25074804 MGI
acts upstream of or within regulation of neuron maturation IGI
IGI: Inferred from genetic interaction
23258346 MGI
acts upstream of or within regulation of neuron migration IMP
IMP: Inferred from mutant phenotype
17409253 MGI
acts upstream of or within regulation of neuronal synaptic plasticity IGI
IGI: Inferred from genetic interaction
25865668 MGI
acts upstream of or within regulation of neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
25865668 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
31369617 MGI
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
31369617 MGI
involved in regulation of receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
27050391 MGI
involved in regulation of synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
34269176 MGI
involved in regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
34269176 MGI
involved in response to lipopolysaccharide IDA
IDA: Inferred from direct assay
35263589 MGI
involved in ruffle assembly IMP
IMP: Inferred from mutant phenotype
10934045 MGI
acts upstream of or within small GTPase-mediated signal transduction IDA
IDA: Inferred from direct assay
12525493 MGI
acts upstream of or within substrate adhesion-dependent cell spreading IDA
IDA: Inferred from direct assay
18156211 MGI
involved in substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
19625648 MGI
acts upstream of or within synaptic transmission, GABAergic IGI
IGI: Inferred from genetic interaction
23258346 MGI
Cellular Component GO Annotation Evidence References Source
located in cell projection IDA
IDA: Inferred from direct assay
15728722 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12213441 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
12783890 MGI
located in early endosome membrane IDA
IDA: Inferred from direct assay
25074804 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
31369617 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
31369617 MGI
located in kinocilium IDA
IDA: Inferred from direct assay
23533177 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
12783890 MGI
located in membrane IDA
IDA: Inferred from direct assay
14657280 MGI
located in nucleus IDA
IDA: Inferred from direct assay
25074804 MGI
located in pericentriolar material IDA
IDA: Inferred from direct assay
23533177 MGI
located in phagocytic cup IDA
IDA: Inferred from direct assay
10934045 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
14516655 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
34269176 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
34269176 MGI
located in ruffle membrane IDA
IDA: Inferred from direct assay
10934045 MGI
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
34269176 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ras-related C3 botulinum toxin substrate 1

  • RAS-related C3 botulinum substrate 1

  • p21-Rac1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-10071A Y-27632 hydrochloride hydrate 99.65% Phase 3
HY-112842 MBQ-167 Inhibitor 99.85% Phase 1

Pre-clinical Phase

Bioactive Molecules (95)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10071 Y-27632 99.91% Unkown
HY-18723 Yoda 1 99.97% Unkown
HY-15723A NSC 23766 trihydrochloride 99.41% Unkown
HY-12755 ML141 99.96% Unkown
HY-12646 Rhosin hydrochloride 99.94% Unkown
HY-16659 EHT 1864 Inhibitor 99.85% Unkown
HY-12810 EHop-016 Inhibitor 99.38% Unkown
HY-125792 Nexinhib20 Inhibitor 99.86% Unkown
HY-12646A Rhosin 98.74% Unkown
HY-100047 Nα,Nα-Bis(carboxymethyl)-L-lysine 98.80% Unkown
HY-124306 ML-099 Activator 99.75% Unkown
HY-110100 CPYPP Inhibitor 99.80% Unkown
HY-104064 1A-116 99.72% Unkown
HY-115376 Z62954982 Inhibitor 99.38% Unkown
HY-N0710 alpha-Cyperone 99.68% Unkown
HY-U00145 Digeranyl bisphosphonate Inhibitor 99.07% Unkown
HY-107501 (Rac)-1-Oleoyl lysophosphatidic acid sodium 98.0% Unkown
HY-113849 MLS-573151 Inhibitor 99.66% Unkown
HY-118208 ML-097 Inhibitor 99.90% Unkown
HY-136383 AZA1 98.17% Unkown
HY-111355 Cholesterol sulfate 98.49% Unkown
HY-119576 Phox-I2 Inhibitor 99.46% Unkown
HY-B0580B (R)-Ketorolac Inhibitor 99.35% Unkown
HY-106381 Aurothiomalate sodium Inhibitor 98.0% Unkown
HY-102078 ZINC69391 99.12% Unkown
HY-15031 l-Naproxen Inhibitor 99.63% Unkown
HY-175341 Rac1-IN-5 Inhibitor 99.84% Unkown
HY-112307A (Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium 99.97% Unkown
HY-133146 DJ001 Inhibitor 99.92% Unkown
HY-158304 Rac1-IN-4 Inhibitor 98.61% Unkown
HY-106381A Aurothiomalate tetramer sodium Inhibitor 98.0% Unkown
HY-120213 YH-306 98.34% Unkown
HY-143699S (Rac)-1,2-Bis-palmitol-3-chloropropanediol-d5 98.51% Unkown
HY-50733A CX-5011 99.48% Unkown
HY-P10038A mP6 TFA Inhibitor 98.48% Unkown
HY-121667 Scaff10-8 Inhibitor 99.11% Unkown
HY-131598C 6-Thio-GTP tetrasodium Inhibitor 99.7% Unkown
HY-156668 Rac1-IN-3 Inhibitor 98.94% Unkown
HY-P1382A Rac1 Inhibitor W56 TFA Inhibitor 99.92% Unkown
HY-RS11591 RAC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W127391 1,2-Dilaurin 98.0% Unkown
HY-152095 PPI-GIT1/β-Pix PPI-IN-1 Inhibitor 99.01% Unkown
HY-180801 E8431 97.34% Unkown
HY-W013060 (Rac)-1,2-Dilinoleoyl-3-palmitoyl-glycerol 99.0% Unkown
HY-W127550 1,2-Dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium / Unkown
HY-50733 CX-5011 free base / Unkown
HY-W778471 rac-1-Linoleoyl-3-linolenoyl-propanetriol 98.64% Unkown
HY-115507 NMac1 / Unkown
HY-109541S6 (Rac)-Colfosceril miristate-d72 / Unkown
HY-120229 GGTI-2147 Inhibitor / Unkown
HY-137862A (Rac)-1-Oleoyl lysophosphatidic acid Control / Unkown
HY-144624 PROTAC Axl Degrader 1 / Unkown
HY-146841S1 (Rac)-Lysophosphatidylcholine C19:0-d5 / Unkown
HY-147076 20:4 PG sodium / Unkown
HY-170458 18:0-18:2 PG sodium / Unkown
HY-172917 Rho GTPase inhibitor 1 Inhibitor / Unkown
HY-180371 NF-115 Inducer / Unkown
HY-183246 Rac/Cdc42-IN-1 Inhibitor / Unkown
HY-184184 Axl ligand-1 Ligand / Unkown
HY-E70632 PIP5K1B Recombinant Human Active Lipid Kinase / Unkown
HY-N8960A (Rac)-1-Hydroxybisabola-2,10-dien-4-one / Unkown
HY-P10038 mP6 Inhibitor / Unkown
HY-P10107 TAT-PAK18 R192A Control / Unkown
HY-P11092 TLQP-62 (mouse,rat) / Unkown
HY-P1382 Rac1 Inhibitor W56 Inhibitor / Unkown
HY-P1383A Rac1 Inhibitor F56, control peptide TFA Inhibitor / Unkown
HY-RS12018 RNASE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W010270A Aurothiomalate disodium Inhibitor / Unkown
HY-W127356 (Rac)-1,2-Distearoyl-3-chloropropanediol-d5 / Unkown
HY-W127363 (Rac)-1,2-Dihexadecylglycerol / Unkown
HY-W127415 (Rac)-1-Stearoyl-3-chloropropanediol / Unkown
HY-W127415S (Rac)-1-Stearoyl-3-chloropropanediol-d5 / Unkown
HY-W127415S1 (Rac)-1-Stearoyl-3-chloropropanediol-d5-1 / Unkown
HY-W127570 rac-1,2-Distearoyl-3-chloropropanediol / Unkown
HY-W587715S (Rac)-1,2-Dioleoyl-3-chloropropanediol-d5 / Unkown
HY-W653931 rac 1,2-Bis-palmitoyl-3-chloropropanediol-13C3 / Unkown
HY-W749785 rac-1-Lauroyl-2-decanoyl-3-chloropropanediol-d5 / Unkown
HY-W766801 1-Linoleoyl-3-chloropropanediol-d5 / Unkown
HY-W766802 rac-1-Linoleoyl-2-linolenoyl-3-chloropropanediol-d5 / Unkown
HY-W767222 rac-1-Linoleoyl-2-chloropropanediol-d5 / Unkown
HY-W767223 rac 1-Palmitoyl-2-chloropropanediol-d5 / Unkown
HY-W770200 rac 1-Oleoyl-2,3-isopropylidieneglycerol-d5 / Unkown
HY-W777103 (Rac)-1-Oleoyl-3-linoleoyl-glycerol / Unkown
HY-W777682 (Rac)-1-Linoleoyl-2,3-isopropylidene-glycerol / Unkown
HY-W777871 rac-1-Palmitoyl-2-linoleoyl-3-chloropropanediol-d5 / Unkown
HY-134243 6-T-GDP Inhibitor / Unkown
HY-181864 Rac1-IN-6 Inhibitor / Unkown
HY-RS16742 Rac1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23179 Rac1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W702728 rac 1-Palmitoyl-2-chloropropanediol / Unkown
HY-W749756 rac-1,2-Distearoyl-3-chloropropanediol-13C3 / Unkown
HY-W766807 rac-1,2-Dilinoleoyl-3-chloropropanediol-d5 / Unkown
HY-W766831 rac 1-oleoyl-2-linoleoyl-3-chloropropanediol-d5 / Unkown
HY-W777865 1-Linoleoyl-3-chloropropanediol / Unkown
HY-W777866 (Rac)-1-Linoleoyl-2-stearoyl-3-chloropropanediol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rac1 NCBI NCBI:5879