2. Gene
  3. LTA - lymphotoxin alpha Gene

LTA - lymphotoxin alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Tnfb

Gene ID: 25008 | Gene type: protein coding

About LTA

Primary_assembly 20: 3,618,853-3,620,859 forward strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 239 orthologues, 8 paralogues and is associated with 55 phenotypes. Biased expression in Spleen (RPKM 15.3), Thymus (RPKM 13.) and 1 other tissue.

Summary

Predicted to enable cytokine activity and tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of fibroblast proliferation; positive regulation of glial cell proliferation; and response to lipopolysaccharide. Located in extracellular space. Biomarker of cystitis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); glucose metabolism disease (multiple); leishmaniasis (multiple); and lung disease (multiple). Orthologous to human LTA (lymphotoxin alpha). [provided by Alliance of Genome Resources, Apr 2022]

LTA Products(1)

mRNA Protein Name
NM_080769.2 NP_542947.1 lymphotoxin-alpha precursor

LTA Protein Structure

TNF

TNF: pfam00229 (73 - 201)

  • 0
  • 100
  • 202 a.a.
Protein Preferred Names Protein Names

lymphotoxin-alpha

LT-alpha

TNF-beta

lymphotoxin A

lymphotoxin alpha (TNF superfamily, member 1)

lymphotoxin-alpha-like

tumor necrosis factor beta

tumor necrosis factor ligand superfamily member 1

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0494 Bufexamac Inhibitor ≥98.0% Unkown
Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99309 Pagibaximab Inhibitor 98.81% Phase 3
Pre-clinical Phase
Bioactive Molecules (23)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103226 SC-57461A Inhibitor 99.89% Unkown
HY-135813 LtaS-IN-1 Inhibitor 98.14% Unkown
HY-137298 LTA4H-IN-1 Inhibitor 98.61% Unkown
HY-125770 5(S)​-​HPETE ≥98.0% Unkown
HY-W004291 Methyl arachidate Inhibitor ≥98.0% Unkown
HY-113446S Leukotriene C4-d5 / Unkown
HY-118795 SC-22716 Inhibitor / Unkown
HY-130441 Leukotriene B3 / Unkown
HY-146811 HSGN-94 Inhibitor / Unkown
HY-149801A Antibacterial agent 140 chloride Inhibitor / Unkown
HY-156960 JNJ-40929837 Inhibitor / Unkown
HY-156960A JNJ-40929837 succinate Inhibitor / Unkown
HY-160646 LTA4H-IN-3 Inhibitor / Unkown
HY-161349 LTA4H-IN-4 Inhibitor / Unkown
HY-163336 14,15-Leukotriene A4 methyl ester / Unkown
HY-N8760 Batatasin IV Inhibitor / Unkown
HY-RS07868 LTA Human Pre-designed siRNA Set A / Unkown
HY-RS07869 Lta Mouse Pre-designed siRNA Set A / Unkown
HY-RS07870 LTA Rat Pre-designed siRNA Set A / Unkown
HY-RS07871 LTA4H Human Pre-designed siRNA Set A / Unkown
HY-W004291R Methyl arachidate (Standard) Inhibitor / Unkown
HY-156416 LtaS-IN-2 Inhibitor / Unkown
HY-162015 LTA4H-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens LTA NCBI NCBI:4049
Canis familiaris LTA NCBI NCBI:607183
Macaca fascicularis LTA NCBI NCBI:102138497
Mus musculus LTA NCBI NCBI:16992
Susscrofa domestica LTA NCBI
Macaca mulatta LTA NCBI NCBI:715425