LTA - lymphotoxin alpha Gene

Also Known as Tnfb

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25008

About LTA

Primary_assembly 20: 3,618,853-3,620,859 forward strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 239 orthologues, 8 paralogues and is associated with 55 phenotypes. Biased expression in Spleen (RPKM 15.3), Thymus (RPKM 13.) and 1 other tissue.

Summary

Predicted to enable cytokine activity and tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of fibroblast proliferation; positive regulation of glial cell proliferation; and response to lipopolysaccharide. Located in extracellular space. Biomarker of cystitis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); glucose metabolism disease (multiple); leishmaniasis (multiple); and lung disease (multiple). Orthologous to human LTA (lymphotoxin alpha). [provided by Alliance of Genome Resources, Apr 2022]

LTA Products (1)

mRNA Protein Name
NM_080769.2 NP_542947.1 lymphotoxin-alpha precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in negative regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
1080770 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
9798700 RGD
involved in positive regulation of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
11595667 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
15197744 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
12849708 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
12122042 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
20298761 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
1080770 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LTA Protein Structure

TNF

TNF: pfam00229 (73 - 201)

  • 0
  • 100
  • 202 a.a.
Protein Preferred Names Protein Names

lymphotoxin-alpha

  • LT-alpha

  • TNF-beta

  • lymphotoxin A

  • lymphotoxin alpha (TNF superfamily, member 1)

  • lymphotoxin-alpha-like

  • tumor necrosis factor beta

  • tumor necrosis factor ligand superfamily member 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0494 Bufexamac Inhibitor 98.47% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-156960A JNJ-40929837 succinate Inhibitor / Phase 2
HY-137298A LYS006 hydrochloride Inhibitor / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99309 Pagibaximab Inhibitor 98.81% Phase 3

Pre-clinical Phase

Bioactive Molecules (41)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W074890 Palmitoylglycine Modulator 99.84% Unkown
HY-137298 LYS006 Inhibitor 98.41% Unkown
HY-P1116A PBP10 TFA Inhibitor 98.22% Unkown
HY-103226 SC-57461A Inhibitor 99.93% Unkown
HY-135813 LtaS-IN-1 Inhibitor 99.58% Unkown
HY-10320A Doramapimod hydrochloride Inhibitor 98.29% Unkown
HY-P1116 PBP10 98.13% Unkown
HY-113446S Leukotriene C4-d5 97.9% Unkown
HY-164051 1650-M15 Inhibitor 99.33% Unkown
HY-112621 Leukotriene A4 methyl ester 99.9% Unkown
HY-146811 HSGN-94 Inhibitor 98.80% Unkown
HY-P5255 Oligopeptide-10 Inhibitor 99.91% Unkown
HY-129461 Dibenzyl trisulfide Inducer 98.24% Unkown
HY-W004291 Methyl arachidate Inhibitor 98.0% Unkown
HY-W097753 4-MDM 99.64% Unkown
HY-N8760 Batatasin IV Inhibitor 98.33% Unkown
HY-10826 DG051 free acid Inhibitor / Unkown
HY-10828 SC-57461 Inhibitor / Unkown
HY-115500 PL265 / Unkown
HY-118795 SC-22716 Inhibitor / Unkown
HY-119023 JNJ-26993135 Inhibitor 99.30% Unkown
HY-130441 Leukotriene B3 / Unkown
HY-149801A Antibacterial agent 140 chloride Inhibitor / Unkown
HY-156960 JNJ-40929837 Inhibitor / Unkown
HY-160541 Mal-PEG2000-NHS ester / Unkown
HY-160646 LTA4H-IN-3 Inhibitor / Unkown
HY-161349 LTA4H-IN-4 Inhibitor / Unkown
HY-162710 LTA4H-IN-5 Inhibitor / Unkown
HY-163336 14,15-Leukotriene A4 methyl ester / Unkown
HY-P11909 3-WP / Unkown
HY-RS07868 LTA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07869 Lta Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07870 LTA Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07871 LTA4H Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W004291R Methyl arachidate (Standard) Inhibitor / Unkown
HY-156416 LtaS-IN-2 Inhibitor / Unkown
HY-162015 LTA4H-IN-2 Inhibitor / Unkown
HY-174588 Human LTA mRNA / Unkown
HY-RS17060 Lta4h Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23504 Lta4h Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W004291S Methyl arachidate-d39 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens LTA NCBI NCBI:4049