Stat1 - signal transducer and activator of transcription 1 Gene

Also Known as DD6G4-4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25124

Summary

Enables CCR5 Chemokine Receptor binding activity; protein Phosphatase 2A binding activity; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of smooth muscle cell proliferation; and receptor signaling pathway via JAK-STAT. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in several cellular components, including axon; dendrite; and nucleus. Used to study pulmonary fibrosis. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 31A; immunodeficiency 31B; immunodeficiency 31C; and prostate adenocarcinoma. Orthologous to human STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Apr 2022]

Stat1 Products (2)

mRNA Protein Name
NM_001034164.1 NP_001029336.1 signal transducer and activator of transcription 1-alpha/beta isoform beta
NM_032612.3 NP_116001.2 signal transducer and activator of transcription 1-alpha/beta isoform alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables CCR5 chemokine receptor binding IPI
IPI: Inferred from physical interaction
14674010 RGD
enables DNA binding IDA
IDA: Inferred from direct assay
7519422 RGD
enables protein phosphatase 2A binding IPI
IPI: Inferred from physical interaction
17084018 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16648019 RGD
Biological Process GO Annotation Evidence References Source
involved in blood circulation IMP
IMP: Inferred from mutant phenotype
17361215 RGD
involved in cell surface receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
12191995 RGD
acts upstream of or within cellular response to cytokine stimulus IDA
IDA: Inferred from direct assay
19414010 RGD
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
15749807 RGD
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
19414010 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15948243 RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process IMP
IMP: Inferred from mutant phenotype
22788969 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17293493 RGD
involved in response to cAMP IDA
IDA: Inferred from direct assay
9144559 RGD
involved in response to cytokine IDA
IDA: Inferred from direct assay
17694433 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
17607690 RGD
involved in response to mechanical stimulus IDA
IDA: Inferred from direct assay
15350851 RGD
involved in response to nutrient IDA
IDA: Inferred from direct assay
15454281 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18031608 RGD
involved in response to peptide hormone IDA
IDA: Inferred from direct assay
15749807 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
17293493 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
14642652 RGD
located in dendrite IDA
IDA: Inferred from direct assay
14642652 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

signal transducer and activator of transcription 1-alpha/beta

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-117287 Deucravacitinib Inhibitor 99.93% Unkown
HY-15136 Lonafarnib Activator 99.85% Yes

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-16997 Itacitinib Inhibitor 99.97% Phase 3
HY-112288 C188-9 Inhibitor 99.84% Phase 2
HY-106981 Orazipone Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (41)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W008510 2-Chloro-5-(trifluoromethyl)pyrimidine Inducer 99.96% Unkown
HY-115594 Erasin Inhibitor 96.02% Unkown
HY-173236 STAT4-IN-1 Inhibitor 99.17% Unkown
HY-119024 BCI-137 Activator 99.84% Unkown
HY-170621 STAT1/3-IN-1 Inhibitor 99.23% Unkown
HY-116940 Sm4 Inhibitor 99.01% Unkown
HY-122891 SB02024 Activator 99.70% Unkown
HY-W031757 Anthraquinone-2-carboxylic acid Inhibitor 98.0% Unkown
HY-149209 LL-K8-22 Inhibitor 99.06% Unkown
HY-169360 SD-436 Degrader 98.27% Unkown
HY-158142 PROTAC TYK2 degrader-1 Inhibitor 99.55% Unkown
HY-N12586 Pheophytin a Inhibitor 80.0% Unkown
HY-17663 KMR-206 Activator 99.86% Unkown
HY-111493 LRRK2 inhibitor 1 Inhibitor 99.80% Unkown
HY-156466 QL-1200186 Inhibitor 99.95% Unkown
HY-161060 Zharp1-211 Inhibitor 99.15% Unkown
HY-181792 ZDZ-553 Inhibitor 99.91% Unkown
HY-173679 RBN012811 Activator 98.79% Unkown
HY-181653 PROTAC SKP2 Degrader-1 Modulator 99.91% Unkown
HY-16997A Itacitinib adipate Inhibitor 99.18% Yes
HY-P1758 IFN-α Receptor Recognition Peptide 1 Inhibitor / Unkown
HY-P1758A IFN-α Receptor Recognition Peptide 1 acetate Inhibitor 99.29% Unkown
HY-119956 Biflorin Inhibitor 99.54% Unkown
HY-187035 SNX631 Inhibitor / Unkown
HY-180226 Apoptosis inducer 55 Inhibitor / Unkown
HY-15136B (Rac)-Lonafarnib Activator / Unkown
HY-178916 ITA-9 Inhibitor / Unkown
HY-183554 Fa-Au Activator / Unkown
HY-179288 TPST2-IN-1 / Unkown
HY-P11915 GG13 Inhibitor / Unkown
HY-186227 ISS840 Inhibitor / Unkown
HY-178716 PTPN2/1-IN-4 Modulator / Unkown
HY-183748 Polθ-IN-11 Activator / Unkown
HY-114178 CDK8-IN-2 Inhibitor / Unkown
HY-178915 ITA-5 Inhibitor / Unkown
HY-183537 KSI-028 Inhibitor / Unkown
HY-184592 JAK1-IN-21 Inhibitor / Unkown
HY-184118 ADGRL1-IN-1 Activator / Unkown
HY-183937A PD-305 Activator / Unkown
HY-184119 Pabgraminone C Modulator / Unkown
HY-183423 MK256 Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99143 Anti-Mouse NK1.1 Antibody (PK136) Inhibitor 98.57% Unkown
HY-P992321 BAY-356 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stat1 NCBI NCBI:6772