Dyrk1a - dual specificity tyrosine phosphorylation regulated kinase 1A Gene

Also Known as Dyrk; PSK47

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25255

About Dyrk1a

Primary_assembly 11: 33,890,490-34,009,420 forward strand.mRatBN7.2:CM026984.1

This gene has 4 transcripts (splice variants), 236 orthologues, 11 paralogues and is associated with 20 phenotypes. Biased expression in Thymus (RPKM 179.), Muscle (RPKM 155.4) and 9 other tissues.

Summary

Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in protein phosphorylation and regulation of RNA splicing. Located in nuclear speck. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Dyrk1a Products (1)

mRNA Protein Name
NM_012791.3 NP_036923.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28755400 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
11877424 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
8631952 RGD
enables protein serine/threonine kinase activity IGI
IGI: Inferred from genetic interaction
25556849 RGD
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
8631952 RGD
Biological Process GO Annotation Evidence References Source
involved in calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
21273244 RGD
involved in cardiac muscle hypertrophy IEP
IEP: Inferred from expression pattern
19906449 RGD
involved in negative regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
27056896 RGD
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
21215488 RGD
involved in peptidyl-serine phosphorylation IGI
IGI: Inferred from genetic interaction
25556849 RGD
involved in peptidyl-threonine phosphorylation IGI
IGI: Inferred from genetic interaction
25556849 RGD
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
8631952 RGD
involved in positive regulation of RNA splicing IMP
IMP: Inferred from mutant phenotype
28377597 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
8631952 RGD
involved in protein import into nucleus IDA
IDA: Inferred from direct assay
21273244 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
8631952 RGD
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
22767602 RGD
involved in regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
27056896 RGD
involved in regulation of cell growth involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
21273244 RGD
Cellular Component GO Annotation Evidence References Source
located in nuclear speck IDA
IDA: Inferred from direct assay
9748265 RGD
NOT located in nucleolus IDA
IDA: Inferred from direct assay
9748265 RGD
located in nucleus IDA
IDA: Inferred from direct assay
9748265 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dyrk1a Protein Structure

PKc_DYRK1

PKc_DYRK1: cd14226 (147 - 483)

  • 0
  • 200
  • 400
  • 600
  • 763 a.a.
Protein Preferred Names Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 1A

  • Dual Specificity Yak1-related kinase

  • MNBH

  • RP86

  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

  • protein kinase minibrain homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-X0009 Tambiciclib 99.68% Phase 2
HY-105309 GSK-626616 Inhibitor 99.88% Phase 1

Pre-clinical Phase

Bioactive Molecules (83)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-142295 GNF2133 Inhibitor 99.67% Unkown
HY-115470 CLK-IN-T3 Inhibitor 99.78% Unkown
HY-129492 GNF4877 Inhibitor 99.82% Unkown
HY-101298 Paprotrain Inhibitor 99.85% Unkown
HY-108476 INDY Inhibitor 99.32% Unkown
HY-112296 T025 99.64% Unkown
HY-15569 NU6102 Inhibitor 99.23% Unkown
HY-15951 ML167 Inhibitor 98.62% Unkown
HY-111380 EHT 1610 Inhibitor 98.93% Unkown
HY-132308 DYRK1-IN-1 Inhibitor 99.71% Unkown
HY-12838 RO5454948 Inhibitor 99.53% Unkown
HY-101029 MBM-55 99.94% Unkown
HY-155723 Leucettinib-92 Inhibitor 98.54% Unkown
HY-146221 Dyrk1A-IN-5 Inhibitor 98.06% Unkown
HY-144290 ARN25068 Inhibitor 98.19% Unkown
HY-135906 CK2/ERK8-IN-1 99.0% Unkown
HY-P5430 DYRKtide 98.59% Unkown
HY-147060 Dyrk1A-IN-3 Inhibitor 99.68% Unkown
HY-147066 Dyrk1A-IN-4 Inhibitor 99.30% Unkown
HY-111379 EHT 5372 Inhibitor 98.12% Unkown
HY-110052 TBCA Inhibitor 99.45% Unkown
HY-34222 7-Deazaguanine Inhibitor 99.73% Unkown
HY-149262 CLK1-IN-3 98.54% Unkown
HY-142295A GNF2133 hydrochloride Inhibitor 99.86% Unkown
HY-156816 ON 108600 Inhibitor 98.65% Unkown
HY-128758A DYRKs-IN-1 hydrochloride Inhibitor 98.29% Unkown
HY-12828A KH-CB20 Inhibitor 99.80% Unkown
HY-X0009A Tambiciclib dimaleate 99.53% Unkown
HY-176723 RD0392 Inhibitor 99.93% Unkown
HY-148105 DS12881479 99.63% Unkown
HY-RS04095 Dyrk1a Mouse Pre-designed siRNA Set A / Unkown
HY-128758 DYRKs-IN-1 Inhibitor / Unkown
HY-176402 Dyrk1A-IN-13 Inhibitor 99.43% Unkown
HY-179177 AO-365/43472821 Inhibitor 99.94% Unkown
HY-402805 DYRK2-IN-2 Inhibitor / Unkown
HY-402805A DYRK2-IN-2 hydrochloride Inhibitor / Unkown
HY-N12625 (R)-(+)-O-Demethylbuchenavianine Inhibitor 98.67% Unkown
HY-101029A MBM-55S / Unkown
HY-122670 VS-II-173 / Unkown
HY-125288 DS42450411 Inhibitor / Unkown
HY-128759 DYRKs-IN-2 Inhibitor / Unkown
HY-129449 AnnH31 Inhibitor 99.91% Unkown
HY-139830 Dyrk1A-IN-1 Inhibitor / Unkown
HY-144614 JH-XVII-10 / Unkown
HY-144617 JH-XIV-68-3 Inhibitor / Unkown
HY-144695 Dyrk1A/α-synuclein-IN-1 Inhibitor / Unkown
HY-144696 Dyrk1A/α-synuclein-IN-2 Inhibitor / Unkown
HY-144826 ZDWX-25 Inhibitor / Unkown
HY-146337 Dyrk1A/B-IN-1 Inhibitor / Unkown
HY-146586 Haspin-IN-1 Inhibitor / Unkown
HY-146587 Haspin-IN-2 Inhibitor / Unkown
HY-150537 AChE/GSK-3β-IN-1 Inhibitor / Unkown
HY-152183 FINDY Inhibitor / Unkown
HY-157995 Dyrk1A-IN-7 Inhibitor / Unkown
HY-158212 Dyrk1A-IN-8 Inhibitor / Unkown
HY-159496 Dyrk1A-IN-10 Inhibitor / Unkown
HY-163514 hAChE-IN-8 Inhibitor / Unkown
HY-171881 BI-5521 Inhibitor / Unkown
HY-173615 KTD-092 Inhibitor / Unkown
HY-179538 CSH-4044 Inhibitor / Unkown
HY-179599 Dyrk1A-IN-15 Inhibitor / Unkown
HY-179600 Dyrk1A-IN-16 Inhibitor / Unkown
HY-180817 CDK2-IN-55 98.91% Unkown
HY-183584 ARN25699 / Unkown
HY-184276 CLK1-IN-5 Inhibitor / Unkown
HY-N17356 Atalaphyllidine Inhibitor / Unkown
HY-N2892 Aristolactam A IIIa Inhibitor / Unkown
HY-P3992 5-FAM-Dyrktide / Unkown
HY-RS04094 DYRK1A Human Pre-designed siRNA Set A / Unkown
HY-RS04096 Dyrk1a Rat Pre-designed siRNA Set A / Unkown
HY-W409652 CLK1/4-IN-2 Inhibitor / Unkown
HY-108475 ProINDY Inhibitor 99.55% Unkown
HY-122989 Aristolactam BIII Inhibitor / Unkown
HY-147760 Dyrk1A-IN-2 Inhibitor / Unkown
HY-162107 Dyrk1A-IN-6 Inhibitor / Unkown
HY-162597 Dyrk1A-IN-9 Inhibitor / Unkown
HY-168265 Dyrk1A-IN-11 Inhibitor / Unkown
HY-170940 Dyrk1A-IN-12 Inhibitor / Unkown
HY-181046 Multi-kinase-IN-14 / Unkown
HY-181085 RD0448 Inhibitor / Unkown
HY-183955 GNF7156 Inhibitor / Unkown
HY-N20713 Licocoumarone / Unkown
HY-W067583 Norharmine Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dyrk1a NCBI NCBI:1859