2. Gene
  3. XIAP - X-linked inhibitor of apoptosis Gene

XIAP - X-linked inhibitor of apoptosis Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Api3; Birc4; riap3

Gene ID: 63879 | Gene type: protein coding

About XIAP

Primary_assembly X: 120,897,907-120,934,700 forward strand.mRatBN7.2:CM026994.1

This gene has 3 transcripts (splice variants), 217 orthologues, 8 paralogues and is associated with 20 phenotypes. Biased expression in Liver (RPKM 22.3), Lung (RPKM 186.7) and 9 other tissues.

Summary

Enables protease binding activity and scaffold protein binding activity. Involved in negative regulation of neuron apoptotic process. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 2 and prostate Cancer. Orthologous to several human genes including XIAP (X-linked inhibitor of Apoptosis). [provided by Alliance of Genome Resources, Apr 2022]

XIAP Products(1)

mRNA Protein Name
NM_022231.2 NP_071567.1 E3 ubiquitin-protein ligase XIAP

XIAP Protein Structure

BIR

BIR: cd00022 (67 - 134)

BIR

BIR: smart00238 (201 - 271)

BIR

BIR: smart00238 (303 - 369)

UBA_BIRC4_8

UBA_BIRC4_8: cd14395 (408 - 457)

RING-HC_BIRC4_8

RING-HC_BIRC4_8: cd16714 (472 - 535)

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  • 536 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase XIAP

IAP homolog A

IAP-3

RIAP-3

RING-type E3 ubiquitin transferase XIAP

X-linked IAP

X-linked inhibitor of apoptosis protein

X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase

apoptosis inhibitor protein 3

baculoviral IAP repeat-containing 4

baculoviral IAP repeat-containing protein 4

inhibitor of apoptosis protein 3

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15454 Xevinapant Antagonist 99.94% Phase 3
HY-13208 Xevinapant hydrochloride Antagonist 98.80% Phase 3
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12600 AZD5582 Antagonist 98.21% Unkown
HY-17473 Embelin Antagonist 98.75% Unkown
HY-110346 AZD5582 dihydrochloride Antagonist 98.67% Unkown
HY-151966 TD1092 Degrader 99.49% Unkown
HY-125378 SBP-0636457 Antagonist 98.42% Unkown
HY-102051 XIAP/cIAP1 antagonist-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens XIAP NCBI NCBI:331