XIAP - X-linked inhibitor of apoptosis Gene

Also Known as Api3; Birc4; riap3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 63879

About XIAP

Primary_assembly X: 120,897,907-120,934,700 forward strand.mRatBN7.2:CM026994.1

This gene has 3 transcripts (splice variants), 217 orthologues, 8 paralogues and is associated with 20 phenotypes. Biased expression in Liver (RPKM 22.3), Lung (RPKM 186.7) and 9 other tissues.

Summary

Enables protease binding activity and scaffold protein binding activity. Involved in negative regulation of neuron apoptotic process. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 2 and prostate Cancer. Orthologous to several human genes including XIAP (X-linked inhibitor of Apoptosis). [provided by Alliance of Genome Resources, Apr 2022]

XIAP Products (1)

mRNA Protein Name
NM_022231.2 NP_071567.1 E3 ubiquitin-protein ligase XIAP

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protease binding IPI
IPI: Inferred from physical interaction
18485100 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18485100 RGD
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
19416975 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
16157298 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17869439 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
16336964 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18485100 RGD
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17514421 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
19416975 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XIAP Protein Structure

BIR

BIR: cd00022 (67 - 134)

BIR

BIR: smart00238 (201 - 271)

BIR

BIR: smart00238 (303 - 369)

UBA_BIRC4_8

UBA_BIRC4_8: cd14395 (408 - 457)

RING-HC_BIRC4_8

RING-HC_BIRC4_8: cd16714 (472 - 535)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 536 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase XIAP

  • IAP homolog A

  • IAP-3

  • RIAP-3

  • RING-type E3 ubiquitin transferase XIAP

  • X-linked IAP

  • X-linked inhibitor of apoptosis protein

  • X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase

  • apoptosis inhibitor protein 3

  • baculoviral IAP repeat-containing 4

  • baculoviral IAP repeat-containing protein 4

  • inhibitor of apoptosis protein 3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-13208 Xevinapant hydrochloride Antagonist 98.11% Phase 3
HY-109565 Tolinapant 99.81% Phase 2
HY-168739 Topoisomerase I inhibitor 17 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (32)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12600 AZD5582 Antagonist 99.61% Unkown
HY-15454 Xevinapant Antagonist 99.91% Unkown
HY-17473 Embelin Antagonist 99.01% Unkown
HY-N0732 Jolkinolide B Inhibitor 99.65% Unkown
HY-148837 GT19630 Degrader 98.85% Unkown
HY-149924 CST626 Degrader 99.60% Unkown
HY-110346 AZD5582 dihydrochloride Antagonist 99.92% Unkown
HY-178226 PBX-7016 Inhibitor / Unkown
HY-151966 TD1092 Degrader 98.23% Unkown
HY-125378 SBP-0636457 Antagonist 98.30% Unkown
HY-175352 Nurr1 agonist 14 Inducer 99.42% Unkown
HY-179633 ZLMT-72 Inhibitor / Unkown
HY-117356A MRS2693 ammonium Activator / Unkown
HY-111886 KHS108-MV1 Antagonist / Unkown
HY-168893 K882 Inhibitor / Unkown
HY-102051 XIAP/cIAP1 antagonist-1 Inhibitor / Unkown
HY-175448 GNE-1567 Antagonist / Unkown
HY-118522 TP-110 Inhibitor / Unkown
HY-181532 IAP ligand 8 Ligand / Unkown
HY-109565B Tolinapant dihydrochloride / Unkown
HY-175925 XIAP ligand 6 Ligand / Unkown
HY-N18315 (2''S)-2'',3''-Dihydrodelicaflavone Modulator / Unkown
HY-12440 HM90822 Antagonist / Unkown
HY-179023 CDK9-IN-45 Inhibitor / Unkown
HY-175348 XB2M54 Antagonist / Unkown
HY-100682 T-3256336 Inhibitor / Unkown
HY-175450 XIAP ligand-Linker Conjugate 2 Antagonist / Unkown
HY-175449 XIAP ligand 5 Antagonist / Unkown
HY-175444 XIAP ligand-Linker Conjugate 1 Antagonist / Unkown
HY-181533 IAP ligand 9 Ligand / Unkown
HY-181018 Topo I/DDX5-IN-1 Inhibitor / Unkown
HY-123925 CSLP43 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens XIAP NCBI NCBI:331