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Cat. No.: HY-145356

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HbF inducer-1

HbF inducer-1 is an orally bioavailable fetal hemoglobin inducer.

For research use only. We do not sell to patients.

CAS No.: 2987004-95-3
Formula: C₁₈H₁₉N₃O₃
Molecular Weight:325.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

HbF inducer-1 Chemical Structure

CAS No.: 2987004-95-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Help & FAQs
Classifications
Bioz

Biological Activity

Description

HbF inducer-1 is an orally bioavailable fetal hemoglobin inducer.

All Histone Methyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CD34-positive (myeloid/lymphoid) cell	EC₅₀	2.8 μM Compound: 18	Induction of fetal hemoglobin in human bone marrow derived CD34+ cells incubated for 5 days by FITC staining based flow cytometry analysis Induction of fetal hemoglobin in human bone marrow derived CD34+ cells incubated for 5 days by FITC staining based flow cytometry analysis	[PMID: 32717372]

Chemical Information

CAS No. 2987004-95-3
Molecular Weight 325.36
Formula C₁₈H₁₉N₃O₃
SMILES

CC(N1CC2(C1)CC(C2)NC(C3=CC(C4=CC=CC=C4)=NO3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Katayama K, et al. Design, synthesis, and optimization of a series of 2-azaspiro[3.3]heptane derivatives as orally bioavailable fetal hemoglobin inducers. Bioorg Med Chem Lett. 2020 Oct 1;30(19):127425. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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HbF inducer-1

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HbF inducer-1 Related Classifications

HY-145356 Related Classifications