I-BET787
Based on 1 Customer Validation
I-BET787 is a orally active BET bromine domain inhibitor with pIC50s of 7.1 and 5.9 for BRD4 BD1 and BRD4 BD2, respectively. I-BET787 has anti-inflammatory activity in mice.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 2201082-98-4
- Formula: C16H20ClN3O2
- Molecular Weight:321.80
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Storage:
RT, sealed storage, away from moisture and light.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Epigenetics Compound Library
HY-L005
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Immunology/Inflammation Compound Library
HY-L007
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
HY-L025
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Reprogramming Compound Library
HY-L039
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Orally Active Compound Library
HY-L061
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Anti-Blood Cancer Compound Library
HY-L079
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Anti-Hematopathy Compound Library
HY-L171
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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BRD4 BD1 7.1 (pIC50) |
BRD4 BD2 5.9 (pIC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CD1 mice are received a single bolus intraperitoneal (IP) administration of trinitrophenol-keyhole limpet hemocyanin (100 μg/kg)[1]
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Dosage:1.5, 5, or 15 mg/kg
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Administration:p.o; once every day (QD) or twice every day (BID) over a 14 day
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Result:Mouse body weights were not significantly affected across the 14 days.
Demonstrated efficacy in a mouse model of inflammation.
Chemical Information
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CAS No. 2201082-98-4
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Appearance Solid
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Molecular Weight 321.80
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Formula C16H20ClN3O2
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Color White to off-white
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SMILES
CC1=CC(C2=NC(Cl)=CN2CC3CCOCC3)=CN(C1=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
RT, sealed storage, away from moisture and light
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
DMSO : 100 mg/mL (310.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.1075 mL | 15.5376 mL | 31.0752 mL | 77.6880 mL |
| 5 mM | 0.6215 mL | 3.1075 mL | 6.2150 mL | 15.5376 mL | |
| 10 mM | 0.3108 mL | 1.5538 mL | 3.1075 mL | 7.7688 mL | |
| 15 mM | 0.2072 mL | 1.0358 mL | 2.0717 mL | 5.1792 mL | |
| 20 mM | 0.1554 mL | 0.7769 mL | 1.5538 mL | 3.8844 mL | |
| 25 mM | 0.1243 mL | 0.6215 mL | 1.2430 mL | 3.1075 mL | |
| 30 mM | 0.1036 mL | 0.5179 mL | 1.0358 mL | 2.5896 mL | |
| 40 mM | 0.0777 mL | 0.3884 mL | 0.7769 mL | 1.9422 mL | |
| 50 mM | 0.0622 mL | 0.3108 mL | 0.6215 mL | 1.5538 mL | |
| 60 mM | 0.0518 mL | 0.2590 mL | 0.5179 mL | 1.2948 mL | |
| 80 mM | 0.0388 mL | 0.1942 mL | 0.3884 mL | 0.9711 mL | |
| 100 mM | 0.0311 mL | 0.1554 mL | 0.3108 mL | 0.7769 mL |
I-BET787 Related Classifications
HY-163729 Related Classifications
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