Colistin
Based on 29 publication(s) in Google Scholar
Colistin is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli.
For research use only. We do not sell to patients.
- Purity: 95%
- CAS No.: 1066-17-7
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Colistin
More- Cell Host Microbe. 2025 Jun 11;33(6):915-931.e9. [Abstract]
- Cell Host Microbe. 2024 May 13:S1931-3128(24)00137-9. [Abstract]
- Nat Commun. 2024 Sep 10;15(1):7914. [Abstract]
- Nat Commun. 2022 Mar 2;13(1):1116. [Abstract]
- Adv Sci (Weinh). 2020 Jul 21;7(17):2001374. [Abstract]
- Dev Cell. 2025 May 15:S1534-5807(25)00287-4. [Abstract]
- Food Res Int. 2026 Jul 31:236:119200. [Abstract]
- Clin Microbiol Infect. 2020 Sep;26(9):1264-1265. [Abstract]
- Cell Mol Gastroenterol Hepatol. 2025 Feb 7:101474. [Abstract]
- Emerg Microbes Infect. 2024 Dec;13(1):2321981. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- Int Immunopharmacol. 2025 May 21:159:114888. [Abstract]
- Arthritis Res Ther. 2025 Jul 7;27(1):137. [Abstract]
- Sci Rep. 2025 May 8;15(1):16114. [Abstract]
- Microorganisms. 2024 Mar 13;12(3):575. [Abstract]
- Antimicrob Agents Chemother. 2025 Aug 6;69(8):e0037925. [Abstract]
- Microbiol Spectr. 2026 Mar 23:e0328925. [Abstract]
- Hum Exp Toxicol. 2021 Oct;40(10):1767-1780. [Abstract]
- Infect Drug Resist. 2026 May 8;19.
- Animal Diseases. 2024 Apr 3.
- Anim Dis. 2021;1(1):26. [Abstract]
- PLoS One. 2025 Jul 10;20(7):e0328167. [Abstract]
- Vet Microbiol. 2024 May:292:110046. [Abstract]
- J Antibiot (Tokyo). 2025 Mar;78(4):265-273. [Abstract]
- J Antibiot (Tokyo). 2019 Aug;72(8):600-604. [Abstract]
- J Microbiol Methods. 2026 Feb 25:107441. [Abstract]
- bioRxiv. 2025 January 25.
- bioRxiv. 2025 January 19.
- Patent. US20200101105A1.
Customer Validation & Images
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Histological Imaging/Staining
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RT-PCR
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Histological Imaging/Staining
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Histological Imaging/Staining
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In Vivo Efficacy Study
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Biological Activity
Colistin (16 mg/kg/day, i.p.) has elevated blood urea nitrogen (BUN), creatinine, and pathologic evidence of acute tubular necrosis and apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57/BL6 mice[1]
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Dosage:16 mg/kg/day
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Administration:16 mg/kg/day, i.p.
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Result:Detected apoptosis, necrosis PCNA staining in mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1066-17-7
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Appearance Solid
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Color White to off-white
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SMILES
[H][C@@]([C@@H](C)O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](N1)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)CCN)=O)C(NCC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCC[R])=O)CCN)=O)[C@@H](C)O)=O)CCN)=O)C1=O)=O.[C]C(C)C.[C][C@H](CC)C.[R:].[R:].[Colistin B].[Colistin A]
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Synonyms
Polymyxin E
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (29)
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Journal Impact Factor
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Most Recent
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Cell Host Microbe
Microbiota-derived urocanic acid triggered by tyrosine kinase inhibitors potentiates cancer immunotherapy efficacy. [Abstract]2025 Jun 11;33(6):915-931.e9. PMID: 40441145 -
Cell Host Microbe
Candida albicans accelerates atherosclerosis by activating intestinal hypoxia-inducible factor2α signaling. [Abstract]2024 May 13:S1931-3128(24)00137-9. PMID: 38754418 -
Nat Commun
A mouse protozoan boosts antigen-specific mucosal IgA responses in a specific lipid metabolism- and signaling-dependent manner. [Abstract]2024 Sep 10;15(1):7914. PMID: 39256385
Colistin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 10;15(1):7914. [Abstract]
The relative levels of serum anti-OVA IgA, cecal content anti-OVA IgA, serum total IgA, and cecal content total IgA of control (Ctrl) and T. mu-colonized mice with or without NA+ Colistin sulfate (600μg/mouse) treatments were determined 14 days after intraperitoneal immunization.
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Nat Commun
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]2022 Mar 2;13(1):1116. PMID: 35236849 -
Adv Sci (Weinh)
A Macromolecule Reversing Antibiotic Resistance Phenotype and Repurposing Drugs as Potent Antibiotics. [Abstract]2020 Jul 21;7(17):2001374. PMID: 32995131 -
Dev Cell
Stress-induced pro-inflammatory glioblastoma stem cells secrete TNFAIP6 to enhance tumor growth and induce suppressive macrophages. [Abstract]2025 May 15:S1534-5807(25)00287-4. PMID: 40403724 -
Food Res Int
Fructooligosaccharides alleviate early-life antibiotic-exposed food allergy via the Indole-3-propionic acid-AhR-Nrf2 Axis: A multi-omics prospective cohort study. [Abstract]2026 Jul 31:236:119200. PMID: 42116470 -
Clin Microbiol Infect
Emergence of ceftazidime/avibactam resistance in KPC-8-producing Klebsiella pneumoniae in South America. [Abstract]2020 Sep;26(9):1264-1265. PMID: 32217161 -
Cell Mol Gastroenterol Hepatol
2025 Feb 7:101474. PMID: 39923847 -
Emerg Microbes Infect
AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria. [Abstract]2024 Dec;13(1):2321981. PMID: 38422452 -
Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
Int Immunopharmacol
Early-life antibiotic dysbiosis impairs microbial tryptophan- nicotinic acid metabolism exacerbating food allergy in adulthood. [Abstract]2025 May 21:159:114888. PMID: 40403504 -
Arthritis Res Ther
Gut microbiome dysbiosis accelerates osteoarthritis progression by inducing IFP-SM inflammation in "double-hit" mice. [Abstract]2025 Jul 7;27(1):137. PMID: 40624668
Colistin purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137. [Abstract]
Colistin sulfate (150 mg/L; 12 weeks). The colonic tissue IF results showed significantly decreased expression of Occludin and, in particular, ZO-1 in the colistin and E. coli groups.
Colistin purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137. [Abstract]
Colistin sulfate (150 mg/L; 12 weeks). Significantly decreased mRNA expression of Occludin and ZO-1 was observed in the colistin and E. coli groups compared with the control group.
Colistin purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137. [Abstract]
Colistin sulfate (150 mg/L; 12 weeks) was administered. Representative images of H&E, Safranin O, AB, and TB staining of the mice tibial plateau from the three groups at 12 weeks were obtained.
Colistin purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137. [Abstract]
Colistin sulfate (150 mg/L; 12 weeks). IFP-SM IF revealed that the expression of CD86 increased in the colistin and E. coli groups.
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Sci Rep
Penfluridol synergizes with colistin to reverse colistin resistance in Gram-negative bacilli. [Abstract]2025 May 8;15(1):16114. PMID: 40341530 -
Microorganisms
Antimicrobial Resistance and Genomic Characteristics of Escherichia coli Strains Isolated from the Poultry Industry in Henan Province, China. [Abstract]2024 Mar 13;12(3):575. PMID: 38543626
Colistin purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575. [Abstract]
Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.
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Antimicrob Agents Chemother
Activity of ampicillin-sulbactam, sulbactam-durlobactam, and comparators against Acinetobacter baumannii-calcoaceticus complex strains isolated from respiratory and bloodstream sources: results from ACNBio study. [Abstract]2025 Aug 6;69(8):e0037925. PMID: 40673757 -
Microbiol Spectr
Antimicrobial activity of sulbactam-durlobactam against Acinetobacter baumannii-calcoaceticus complex strains causing non-respiratory and non-bloodstream infections from the United States (2023-2025). [Abstract]2026 Mar 23:e0328925. PMID: 41869812 -
Hum Exp Toxicol
Effect of taxifolin/dapagliflozin combination on colistin-induced nephrotoxicity in rats. [Abstract]2021 Oct;40(10):1767-1780. PMID: 33882723 -
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Anim Dis
Pasteurella multocida capsular: lipopolysaccharide types D:L6 and A:L3 remain to be the main epidemic genotypes of pigs in China. [Abstract]2021;1(1):26. PMID: 34778886 -
PLoS One
LubriShieldTM-A permanent urinary catheter coating that prevents uropathogen biofilm formation in vitro independent of host protein conditioning. [Abstract]2025 Jul 10;20(7):e0328167. PMID: 40638652 -
Vet Microbiol
Discovery of the tigecycline resistance gene cluster tmexCD3-toprJ1 in Pasteurella multocida strains isolated from pigs in China. [Abstract]2024 May:292:110046. PMID: 38471428 -
J Antibiot (Tokyo)
In vitro assessment of the synergistic effects of cefotaxime, colistin, and fosfomycin combinations against foodborne resistant Escherichia coli and Salmonella isolates. [Abstract]2025 Mar;78(4):265-273. PMID: 39910346 -
J Antibiot (Tokyo)
In vitro activity of eravacycline in combination with colistin against carbapenem-resistant A. baumannii isolates. [Abstract]2019 Aug;72(8):600-604. PMID: 31028352 -
J Microbiol Methods
Comparison of agar-based and checkerboard methods to assess phage-antimicrobial synergy in Pseudomonas aeruginosa. [Abstract]2026 Feb 25:107441. PMID: 41759663 -
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Solvent & Solubility
H2O : 100 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Silpak Biswas, et al. Colistin: an update on the antibiotic of the 21st century. Expert Rev Anti Infect Ther. 2012 Aug;10(8):917-34. [Content Brief]
[2]. Jian Li, et al. Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate. [Content Brief]
[3]. Michael T Eadon, et al. Cell cycle arrest in a model of colistin nephrotoxicity. Physiol Genomics. 2013 Oct 1;45(19):877-88. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Colistin Related Classifications
HY-113678 Related Classifications
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