2-Hydroxycinnamaldehyde
Based on 1 Customer Validation
2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits Wnt/β-catenin, STAT3 signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 3541-42-2
- Formula: C9H8O2
- Molecular Weight:148.16
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
6.17 μM
Compound: 1
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Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by SRB assay
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[PMID: 23855266] |
| HCT-116 | IC50 |
6.62 μM
Compound: 1
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Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by SRB assay
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[PMID: 23855266] |
| HCT-116 | IC50 |
8.14 μM
Compound: 1
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Cytotoxicity against human HCT116 cells assessed as growth inhibition after 24 hrs by SRB assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 24 hrs by SRB assay
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[PMID: 23855266] |
| SW-620 | GI50 |
15 μM
Compound: 1, HCA
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Cytotoxicity against human SW620 cells after 48 hrs by WST1 assay
Cytotoxicity against human SW620 cells after 48 hrs by WST1 assay
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[PMID: 21183341] |
Chemical Information
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CAS No. 3541-42-2
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Appearance Solid
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Molecular Weight 148.16
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Formula C9H8O2
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Color Light yellow to brown
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SMILES
O=C/C=C/C1=CC=CC=C1O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (674.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Lee MA, et al. Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of β-catenin signaling. J Nat Prod. 2013 Jul 26;76(7):1278-84. [Content Brief]
[2]. Yoon YJ, et al. 2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2. Cancer Lett. 2018 Oct 10;434:42-55. [Content Brief]
[3]. Hao Let al. 2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice. Exp Mol Med. 2021 May;53(5):875-884. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.7495 mL | 33.7473 mL | 67.4946 mL | 168.7365 mL |
| 5 mM | 1.3499 mL | 6.7495 mL | 13.4989 mL | 33.7473 mL | |
| 10 mM | 0.6749 mL | 3.3747 mL | 6.7495 mL | 16.8736 mL | |
| 15 mM | 0.4500 mL | 2.2498 mL | 4.4996 mL | 11.2491 mL | |
| 20 mM | 0.3375 mL | 1.6874 mL | 3.3747 mL | 8.4368 mL | |
| 25 mM | 0.2700 mL | 1.3499 mL | 2.6998 mL | 6.7495 mL | |
| 30 mM | 0.2250 mL | 1.1249 mL | 2.2498 mL | 5.6245 mL | |
| 40 mM | 0.1687 mL | 0.8437 mL | 1.6874 mL | 4.2184 mL | |
| 50 mM | 0.1350 mL | 0.6749 mL | 1.3499 mL | 3.3747 mL | |
| 60 mM | 0.1125 mL | 0.5625 mL | 1.1249 mL | 2.8123 mL | |
| 80 mM | 0.0844 mL | 0.4218 mL | 0.8437 mL | 2.1092 mL | |
| 100 mM | 0.0675 mL | 0.3375 mL | 0.6749 mL | 1.6874 mL |
2-Hydroxycinnamaldehyde Related Classifications
HY-N3149A Related Classifications
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