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Cat. No.: HY-182486

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LEM-06

LEM-06 is an NSD2 inhibitor with a human IC₅₀ of 890 μM and 0.8 mM. LEM-06 binds to the histone-tail binding groove of NSD2-SET, inhibiting NSD2-mediated H3K36 histone methyltransferase activity and H3K36 mono-methylation. LEM-06 serves as a hit molecule for further optimization or derivation to explore NSD2 biology. LEM-06 can be used for the research of multiple myeloma.

For research use only. We do not sell to patients.

CAS No.: 1212675-57-4
Formula: C₂₉H₃₈N₄O₃
Molecular Weight:490.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LEM-06 Chemical Structure

CAS No.: 1212675-57-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

NSD2

890 μM (IC₅₀)

All Histone Methyltransferase Isoforms :

In Vitro

LEM-06 inhibits the H3K36 monomethylation activity of recombinant NSD2-SET protein in vitro, with an IC₅₀ value of 890 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 1212675-57-4
Molecular Weight 490.64
Formula C₂₉H₃₈N₄O₃
SMILES

O=C1N2C([C@@]3([H])CN(C4CCN(CC4)C(C)=O)C[C@@](C3)([H])C2)=CC=C1C5=C(C=CC=C5)CN6CCOCC6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. di Luccio E, et al. Inhibition of Nuclear Receptor Binding SET Domain 2/Multiple Myeloma SET Domain by LEM-06 Implication for Epigenetic Cancer Therapies. J Cancer Prev. 2015;20(2):113-120. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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