2'-Nitroflavone
2'-Nitroflavone is a PARP1 inhibitor. 2'-Nitroflavone inhibits the proliferation, induces cell cycle arrest and apoptosis of triple-negative breast cancer cells. 2'-Nitroflavone also inhibits the migration of triple-negative breast cancer cells and endothelial cells. 2'-Nitroflavone exhibits antitumor activity and can be used in the research of tumors such as triple-negative breast cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 53277-26-2
- 分子式: C15H9NO4
- 分子量:267.24
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
PARP1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| WISH | IC50 |
3 μM
Compound: 14
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In vitro inhibitory activity against the growth of WISH cell derived from human cervical carcinoma was determined
In vitro inhibitory activity against the growth of WISH cell derived from human cervical carcinoma was determined
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[PMID: 14684314] |
体外実験
2'-Nitroflavone (1.25-40 μM; 0-96 h) inhibits the viability of three triple-negative breast cancer (TNBC) cell lines, MDA-MB-231, BT-549 and MDA-MB-468, with IC50 values of 4.0 μM, 9.2 μM and 6.5 μM after 72 h of treatment, respectively and has IC50 against EA.hy926 endothelial cells of 14.5 μM at 96 h[1].
2'-Nitroflavone (0-25 μM; 72-144 h) inhibits colony formation and migration of triple-negative breast cancer cells, and induces cell cycle arrest and apoptosis[1].
2'-Nitroflavone (1-25 μM; 72 h) reduces the protein level of α-tubulin in MDA-MB-231 and BT-549 cells, disrupts the arrangement of α-tubulin in cells, and induces the formation of multipolar mitotic spindles[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231
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Concentration:5 μM
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Incubation Time:72 h
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Result:Induced S and G2/M arrest in MDA-MB-231 cells.
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Cell Line:MDA-MB-231
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Concentration:1, 5, 25 μM
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Incubation Time:72 h
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Result:Significantly decreased viable cells and increased the percentage of early apoptotic cells at 25 μM compared to vehicle.
Significantly increased the percentage of hypodiploid cells at 5 and 25 μM compared to vehicle.
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Cell Line:MDA-MB-231, BT-549
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Concentration:1, 5, 25 μM
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Incubation Time:72 h
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Result:Significantly decreased α-tubulin protein expression in both cell lines at 25 μM.
Did not affect actin protein levels at any concentration tested.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 6-8 weeks old, 20-25 g, orthotopic syngeneic 4T1 cell model)[1]
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Dosage:20 mg/kg
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Administration:i.p.; daily 5 times per week; 2 weeks
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Result:Significantly decreased relative tumor volume compared to vehicle controls.
Had significant differences in body, liver, spleen, heart, or kidney weight between groups.
化学情報
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CAS 番号 53277-26-2
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分子量 267.24
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分子式 C15H9NO4
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SMILES
O=C1C2=CC=CC=C2OC(C3=C([N+]([O-])=O)C=CC=C3)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
2'-Nitroflavone 関連分類
HY-181068 関連分類
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