製品番号: HY-B1618

コルチコステロン

(別名: Corticosterone)

68 Cited Publications

カスタマーレビュー

Based on 68 publication(s) in Google Scholar

Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect.

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純度: 99.77%
CAS 番号: 50-22-6
分子式: C₂₁H₃₀O₄
分子量:346.47

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months

Corticosterone 構造式

CAS 番号: 50-22-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
- 臨床実験
化学情報
Publications (68)
溶剤 & 溶解度
- 体外
- 体内
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

AMPA Receptor

Human Endogenous Metabolite

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

iGluR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.29 μM Compound: Corticosterone	TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 0.25 uM) in OCT3-expressing HEK293 cells TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 0.25 uM) in OCT3-expressing HEK293 cells	[PMID: 12110607]
HEK293	IC₅₀	21.7 μM Compound: Corticosterone	TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 0.25 uM) in OCT1-expressing HEK293 cells TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 0.25 uM) in OCT1-expressing HEK293 cells	[PMID: 12110607]
HEK293	IC₅₀	34.2 μM Compound: Corticosterone	TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 0.25 uM) in OCT2-expressing HEK293 cells TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 0.25 uM) in OCT2-expressing HEK293 cells	[PMID: 12110607]
HEK293	IC₅₀	1.6 μM Compound: corticosterone	Inhibition of the Organic Cation Transporter 3 (OCT3, SLC22A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by MPP+ uptake in HEK-293 JumpIN-SLC22A3 cells Inhibition of the Organic Cation Transporter 3 (OCT3, SLC22A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by MPP+ uptake in HEK-293 JumpIN-SLC22A3 cells	[PMID: 35163125]
HEK293	IC₅₀	1.6 μM Compound: corticosterone	Inhibition of the Organic Cation Transporter 3 (OCT3, SLC22A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by MPP+ uptake in HEK-293 JumpIN-SLC22A3 cells (PubChem AID: 1745861) Inhibition of the Organic Cation Transporter 3 (OCT3, SLC22A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by MPP+ uptake in HEK-293 JumpIN-SLC22A3 cells (PubChem AID: 1745861)	[PMID: 35163125]
HRPE	IC₅₀	4.2 μM Compound: Corticosterone	TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT2-expressing HRPE cells TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT2-expressing HRPE cells	[PMID: 9830022]
HRPE	IC₅₀	4.9 μM Compound: Corticosterone	TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT3-expressing HRPE cells TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT3-expressing HRPE cells	[PMID: 9830022]
Oocyte	IC₅₀	10.7 μM Compound: Corticosterone	TP_TRANSPORTER: inhibition pramipexole uptake in rOCT2-injected oocytes TP_TRANSPORTER: inhibition pramipexole uptake in rOCT2-injected oocytes	[PMID: 15640376]
Oocyte	IC₅₀	163.7 μM Compound: Corticosterone	TP_TRANSPORTER: inhibition pramipexole uptake in rOCT1-injected oocytes TP_TRANSPORTER: inhibition pramipexole uptake in rOCT1-injected oocytes	[PMID: 15640376]

体外実験

Corticosterone (100 nM; 30 min) via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane^[1].
Corticosterone (CORT) (1 μM; 48 h) shows good immunosuppressive properties (functionally compromises maturation of BMDC), which impairs LPS-induced up-regulation of maturation-associated markers (MHC class II, B7.2, B7.1 and CD40)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HEK293 cells
Concentration:

100 nM
Incubation Time:

30 min
Result:

Caused a significant enhancement of mEPSC amplitude (mEPSC represents the postsynaptic response to release of individual vesicles of glutamate).
Increased the transmission of glutamatergic, and increased synaptic AMPAR currents via a Rab4-dependent mechanism.
Profoundly increased surface GluR1 cluster density, cluster size and cluster fluorescence intensity.
Significantly increased the amount of Rab4 that binded to WT-GDI, S45A-GDI, or S121A-GDI but not S213A-GDI.
Induced the phosphorylation of GST-^WTGDI, GST-^S45AGDI, and GST-^S121AGDI, but not GST-^S213AGDI, and this effect was blocked in cells transfected with SGK1 small interfering RNA.
Increased AMPAR surface expression via a mechanism dependent on GDI phosphorylation.

Cell Viability Assay^[2]

Cell Line:

BMDC cells
Concentration:

1 µM
Incubation Time:

48 h
Result:

Completely blocked the expression of MHC class II and B7.2 that induced by LPS, and maximally impaired BMDC cells maturation at 12 h.
Reduced B7.1 by 50%, and slightly down-regulated CD40.

体内実験

Corticosterone results in a marked reduction in the ability of BMDC cells to prime naive CD8⁺ T cells in vivo^[2].
Corticosterone (0.03 or 1 mg/kg; s.c.; single) downregulates expression of BDNF mRNA in dentate gyrus and CA1 of rats^[3].
Corticosterone (2.6 mg/kg; in animal feedings; 8 days) restores ethanol intake and preference to approximately normal preoperative levels in adrenalectomy (ADX) rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult male Wistar rats (150-170 g; adrenalectomized)^[3].
Dosage:

0.03 or 1 mg/kg
Administration:

Subcutaneous injection; single.
Result:

Decreased expression of BDNF mRNA in dentate gyrus, with 25% and 50% lower for dosages of 0.03 and 1 mg/kg, respectively (3 h after administration).
Reduced approximately 40% BDNF mRNA level as compared to the t=0 h control group (3 h after administration), but the level increased by 100% when 12 h after administration (compared to t=3 h and t=6 h group).

Animal Model:

Male Wistar rats (3-week-old; adrenalectomized)^[4].
Dosage:

2.6 mg/kg
Administration:

In animal feedings; 8 days.
Result:

Restored ethanol intake and preference of adrenalectomy (ADX) rats to approximately normal preoperative levels and to the levels observed in the sham-operated group (SH) rats.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 50-22-6
性状 Solid
分子量 346.47
分子式 C₂₁H₃₀O₄
Color White to off-white
SMILES

C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
別名

Corticosterone
Structure Classification
- Steroids
Initial Source
- Endogenous metabolite
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

Publications (68)

All In Vivo Efficacy StudyWB

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Journal Impact Factor

Nature

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation. [Abstract]

2026 Apr;652(8112):1308-1317. PMID: 41741647
Nature

Publisher Correction: Psychedelics elicit their effects by 5-HT2A receptor-mediated Gi signalling. [Abstract]

2026 Mar;651(8104):E5. PMID: 41703299
Cell

Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice. [Abstract]

2026 Apr 2;189(7):2007-2023.e20. PMID: 41785851
Cell

Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration. [Abstract]

2025 Jan 9;188(1):157-174.e22. PMID: 39674178

Corticosterone purchased from MedChemExpress. Usage Cited in: Cell. 2025 Jan 9;188(1):157-174.e22. [Abstract]

Corticosterone (10 mM/50 μL, intradermal injection, single dose) induces widespread lipolysis in dermal adipocytes.
Cell

Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals. [Abstract]

2023 Dec 7;186(25):5500-5516.e21. PMID: 38016470
Cell Metab

Ferroplasticity drives social isolation-induced anxiety via a ventral hippocampal iron-α-synuclein axis. [Abstract]

2026 Jan 27:S1550-4131(25)00586-8. PMID: 41605214
Cell Metab

Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate. [Abstract]

2025 Sep 23:S1550-4131(25)00383-3. PMID: 40992374
Cell Metab

Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury. [Abstract]

2024 Nov 5;36(11):2402-2418.e10. PMID: 39389061
Nat Neurosci

Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties. [Abstract]

2022 Jan;25(1):39-49. PMID: 34887590

Corticosterone purchased from MedChemExpress. Usage Cited in: Nat Neurosci. 2022 Jan;25(1):39-49. [Abstract]

Corticosterone (25 mg/kg, drinking water, 21 days) was administered to male and female mice. Fresh corticosterone-containing water was given every other day in the first 2 weeks, and gradually changed to normal water by halving the dose every 2 days in the last week.
Cell Mol Immunol

2026 May;23(5):546-559. PMID: 41927788
Nat Commun

Photochemical nanomotors reverse anxiety- and depressive-related behaviors in rodents via spatiotemporal polarity dynamics tuning. [Abstract]

2026 Feb 26;17(1):3237. PMID: 41748578
Nat Commun

Coronavirus envelope protein activates TMED10-mediated unconventional secretion of inflammatory factors. [Abstract]

2024 Oct 8;15(1):8708. PMID: 39379362
Adv Sci (Weinh)

Corticosterone Contributes to Context-Triggered Retrieval of Morphine Withdrawal Memories by Acting on Basolateral Amygdala Neurons Projecting to Nucleus Accumbens Core. [Abstract]

2025 Aug 23:e03409. PMID: 40847673
Nat Chem Biol

Structures of the ADGRG2-Gs complex in apo and ligand-bound forms. [Abstract]

2022 Nov;18(11):1196-1203. PMID: 35982227
J Adv Res

OSBPL6 protects against demyelination and behavioral disorder via promoting cholesterol transport in oligodendrocyte. [Abstract]

2026 Jan 26:S2090-1232(26)00091-3. PMID: 41605285
Sci Adv

Microglial BDNF modulates arketamine's antidepressant-like effects through cortico-accumbal pathways. [Abstract]

2025 Jul 11;11(28):eadv5986. PMID: 40632846
Cell Discov

Psychological stress-induced systemic corticosterone directly sabotages intestinal stem cells and exacerbates colitis. [Abstract]

2025 May 13;11(1):46. PMID: 40360481

Corticosterone purchased from MedChemExpress. Usage Cited in: Cell Discov. 2025 May 13;11(1):46. [Abstract]

Corticosterone (5 mg/kg, i.p., once daily for 3 weeks) in C57BL/6 mice. H&E staining and quantification of crypt depth.

Corticosterone purchased from MedChemExpress. Usage Cited in: Cell Discov. 2025 May 13;11(1):46. [Abstract]

Corticosterone (5 mg/kg, i.p., once daily for 3 weeks) in C57BL/6 mice. EdU and Olfm4 co-staining quantification of EdU+ cells per crypt and the percentage of EdU+ Olfm4+ cells.
Cell Discov

Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression. [Abstract]

2023 Aug 29;9(1):90. PMID: 37644025
Sci Adv

Stress-induced reduction of Na+/H+ exchanger isoform 1 promotes maladaptation of neuroplasticity and exacerbates depressive behaviors. [Abstract]

2022 Nov 11;8(45):eadd7063. PMID: 36367929

Corticosterone purchased from MedChemExpress. Usage Cited in: Sci Adv. 2022 Nov 11;8(45):eadd7063. [Abstract]

Corticosterone (CORT) (10 µM, 24 h) is used to produce a cell stress model on the primary culture hippocampal neurons from rats. The decreased NHE1 expression levels in primary cell culture induced by CORT treatment are not affected by chloroquine (Fig. D) but significantly reversed with MG132 pretreatment (Fig. E).
Redox Biol

p53 promote oxidative stress, neuroinflammation and behavioral disorders via DDIT4-NF-κB signaling pathway. [Abstract]

2025 Aug 20:86:103836. PMID: 40848509
Redox Biol

Methionine oxidation of actin cytoskeleton attenuates traumatic memory retention via reactivating dendritic spine morphogenesis. [Abstract]

2024 Nov:77:103391. PMID: 39405981
Gut Microbes

2026 Dec 31;18(1):2657047. PMID: 41964107
Proc Natl Acad Sci U S A

Progesterone activates GPR126 to promote breast cancer development via the Gi pathway. [Abstract]

2022 Apr 12;119(15):e2117004119. PMID: 35394864
Phytomedicine

GSTM2 as the molecular linking of depression-driven colon cancer progression and chemoresistance: Reversal by Sinisan. [Abstract]

2026 Jun:155:158113. PMID: 41962265
Phytomedicine

Tongmai Yishen Formula alleviates post-stroke depression by restoring neuronal homeostasis in the lateral habenula via the ITPKA signaling pathway. [Abstract]

2026 Jan 21:153:157866. PMID: 41655549
Free Radic Biol Med

Chronic stress-induced steroids mediate mitochondrial fission and fibrosis in the trabecular meshwork via the MIEF1-MAOA complex. [Abstract]

2026 Mar 16:246:316-333. PMID: 41579974
Biomed Pharmacother

Rosmarinic acid alleviate CORT-induced depressive-like behavior by promoting neurogenesis and regulating BDNF/TrkB/PI3K signaling axis. [Abstract]

2024 Jan:170:115994. PMID: 38070249
Biomed Pharmacother

Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway. [Abstract]

2024 Jan:170:116012. PMID: 38113631
Anal Chem

High-Throughput Reactive Desorption Electrospray Ionization Mass Spectrometry for Targeted Derivatization and Analysis of Poorly Ionized Small Molecules. [Abstract]

2026 Jun 16;98(23):16962-16970. PMID: 42223360
Int J Nanomedicine

GLX351322-Loaded Nanoparticles Alleviate Chronic Stress-Induced Depressive Behaviors Through Inhibition of Ferroptosis and Oxidative Stress. [Abstract]

2025 Nov 24:20:14033-14055. PMID: 41321900
Neurosci Bull

Sex Differences in Pain Contagion Determined by the Balance of Oxytocin and Corticosterone in the Anterior Cingulate Cortex in Rodents. [Abstract]

2025 Aug 6. PMID: 40767942
Cell Prolif

Regulating the Plasticity of Hippocampal Neurons via Electroacupuncture in Depression Model Mice. [Abstract]

2025 May 15:e70057. PMID: 40374592
Biochem Pharmacol

Brain-derived neurotrophic factor upregulates synaptic GluA1 in the amygdala to promote depression in response to psychological stress. [Abstract]

2021 Oct:192:114740. PMID: 34419429
J Ethnopharmacol

Syringa oblata Lindl extract alleviated corticosterone-induced depression via the cAMP/PKA-CREB-BDNF pathway. [Abstract]

2025 Jan 3:119274. PMID: 39756715
J Ethnopharmacol

Jiao-tai-wan and its effective component-berberine improve diabetes and depressive disorder through the cAMP/PKA/CREB signaling pathway. [Abstract]

2024 Apr 24:324:117829. PMID: 38296172
J Ethnopharmacol

Jiawei-Xiaoyao pill elicits a rapid antidepressant effect, dependent on activating CaMKII/mTOR/BDNF signaling pathway in the hippocampus. [Abstract]

2024 Jan 10;318(Pt B):117016. PMID: 37567427
Cells

Depletion of MGO or Its Derivatives Ameliorate CUMS-Induced Neuroinflammation. [Abstract]

2025 Mar 8;14(6):397. PMID: 40136646
Cells

Monochromatic Light Pollution Exacerbates High-Fat Diet-Induced Adipocytic Hypertrophy in Mice. [Abstract]

2022 Nov 28;11(23):3808. PMID: 36497068
Life Sci

Mfat-1 ameliorates cachexia after hypoxic-ischemic brain damage in mice by protecting the hypothalamus-pituitary-adrenal axis. [Abstract]

2023 Nov 15:333:122172. PMID: 37832632
Inflammation

Arctiin Mitigates Neuronal Injury by Modulating the P2X7R/NLPR3 Inflammasome Signaling Pathway. [Abstract]

2025 Jun;48(3):987-1002. PMID: 39154088
Int J Mol Sci

Glucocorticoids Selectively Inhibit Hippocampal CA1 Pyramidal Neurons Activity Through HCN Channels. [Abstract]

2024 Nov 7;25(22):11971. PMID: 39596039
Int J Mol Sci

FXR Maintains the Intestinal Barrier and Stemness by Regulating CYP11A1-Mediated Corticosterone Synthesis in Biliary Obstruction Diseases. [Abstract]

2023 Aug 30;24(17):13494. PMID: 37686300
Int J Mol Sci

The Corticosterone-Glucocorticoid Receptor-AP1/CREB Axis Inhibits the Luteinizing Hormone Receptor Expression in Mouse Granulosa Cells. [Abstract]

2022 Oct 18;23(20):12454. PMID: 36293309
Int Immunopharmacol

Stress aggravates imiquimod-induced psoriasiform inflammation by promoting M1 macrophage polarization. [Abstract]

2023 Sep 7;124(Pt A):110899. PMID: 37688915
Neuropharmacology

Hippocampal GPR17 down regulation ameliorates CMS-induced depression-like behaviors in mice. [Abstract]

2026 Feb 1:283:110757. PMID: 41192688
Mol Neurobiol

Curcumin Ameliorates Depressive-like Behaviors by Modulating mGluR2/PGC-1α-Mediated Glutamatergic Homeostasis and Mitochondrial Function. [Abstract]

2025 Nov 21;63(1):125. PMID: 41269393
Mol Neurobiol

Ginsenoside Rg1 Reduced Microglial Activation and Mitochondrial Dysfunction to Alleviate Depression-Like Behaviour Via the GAS5/EZH2/SOCS3/NRF2 Axis. [Abstract]

2022 May;59(5):2855-2873. PMID: 35230663
iScience

Glucocorticoid receptor-mediated Nr1d1 chromatin circadian misalignment in stress-induced irritable bowel syndrome. [Abstract]

2023 Jun 17;26(7):107137. PMID: 37404374
ACS Chem Neurosci

Gallic Acid Improves Comorbid Chronic Pain and Depression Behaviors by Inhibiting P2X7 Receptor-Mediated Ferroptosis in the Spinal Cord of Rats. [Abstract]

2023 Feb 15;14(4):667-676. PMID: 36719132
J Neural Eng

Ultrasound neuromodulation ameliorates chronic corticosterone-induced depression- and anxiety-like behaviors in mice. [Abstract]

2023 Jun 22;20(3). PMID: 37321207
Front Med

Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation. [Abstract]

2022 Apr;16(2):227-239. PMID: 35212887
Phytochemistry

Eremophilane sesquiterpenes from agarwood of Aquilaria agallocha with neuroprotective effect. [Abstract]

2025 Apr 28:114527. PMID: 40306531
Toxicol Appl Pharmacol

OAT1/3 regulate the absorption of CP-25 in the rat synovium. [Abstract]

2025 May 4:500:117371. PMID: 40328338
J Pharmacol Sci

MicroRNA-3473b regulates corticosterone-induced microglial polarization and inflammation through TREM2. [Abstract]

2025 Dec;159(4):209-218. PMID: 41241431
Neurogastroenterol Motil

Acute stress induces visceral hypersensitivity via glucocorticoid receptor-mediated membrane insertion of TRPM8: Involvement of a non-receptor tyrosine kinase Pyk2. [Abstract]

2020 Oct;32(10):1514-1528. PMID: 32391653
Brain Sci

Inhibition of Glycolysis Alleviates Chronic Unpredictable Mild Stress Induced Neuroinflammation and Depression-like Behavior. [Abstract]

2024 Oct 30;14(11):1098. PMID: 39595861
Neuroscience

Chronic stress disturbed the metabolism of homocysteine in mouse hippocampus and prefrontal cortex. [Abstract]

2024 Dec 17:563:63-73. PMID: 39521319
Brain Sci

Acute or Chronic Exposure to Corticosterone Promotes Wakefulness in Mice. [Abstract]

2023 Oct 18;13(10):1472. PMID: 37891839
Animals

Corticosterone Injection Impairs Follicular Development, Ovulation and Steroidogenesis Capacity in Mice Ovary. [Abstract]

2019 Nov 29;9(12):1047. PMID: 31795468
Rev Bras Farmacogn

2025 Oct 16.
SSRN

2026 May 15.
Food Safety and Health

2026 Jan 7.
Res Sq

2025 Oct 21.
Res Sq

2024 Aug 06.
Research Square Preprint

2024 Jan 19.
bioRxiv

2023 Dec 26.
SSRN

21 Nov 2022.
Research Square Preprint

2020 Jun.

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (288.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 14.29 mg/mL (41.24 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8863 mL

14.4313 mL

28.8625 mL

5 mM

0.5773 mL

2.8863 mL

5.7725 mL

10 mM

0.2886 mL

1.4431 mL

2.8863 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 4

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1.43 mg/mL (4.13 mM); Clear solution

This protocol yields a clear solution of ≥ 1.43 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (14.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 5

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 1.43 mg/mL (4.13 mM); Clear solution

This protocol yields a clear solution of ≥ 1.43 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (14.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 6

Add each solvent one by one: 10% EtOH 90% Corn Oil

Solubility: ≥ 1.43 mg/mL (4.13 mM); Clear solution

This protocol yields a clear solution of ≥ 1.43 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (14.3 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 0.5% CMC-Na/saline water

Solubility: 2 mg/mL (5.77 mM); Suspended solution; Need ultrasonic and warming and heat to 60°C

Protocol 2

Add each solvent one by one: 20% HP-β-CD in Saline

Solubility: 4 mg/mL (11.55 mM); Suspended solution; Need ultrasonic

Protocol 3

Add each solvent one by one: 5% Cremophor EL 95% (20% HP-β-CD in Saline)

Solubility: 5 mg/mL (14.43 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

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参考文献

[1]. Elftman MD, et al. Corticosterone impairs dendritic cell maturation and function. Immunology. 2007 Oct;122(2):279-90. [Content Brief]

[2]. Schaaf MJ, et al. Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain Res. 1998 Nov 30;813(1):112-20. [Content Brief]

[3]. Fahlke C, et al. Involvement of corticosterone in the modulation of ethanol consumption in the rat. Alcohol. 1994 May-Jun;11(3):195-202. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	2.8863 mL	14.4313 mL	28.8625 mL	72.1563 mL
	5 mM	0.5773 mL	2.8863 mL	5.7725 mL	14.4313 mL
	10 mM	0.2886 mL	1.4431 mL	2.8863 mL	7.2156 mL
	15 mM	0.1924 mL	0.9621 mL	1.9242 mL	4.8104 mL
	20 mM	0.1443 mL	0.7216 mL	1.4431 mL	3.6078 mL
	25 mM	0.1155 mL	0.5773 mL	1.1545 mL	2.8863 mL
	30 mM	0.0962 mL	0.4810 mL	0.9621 mL	2.4052 mL
	40 mM	0.0722 mL	0.3608 mL	0.7216 mL	1.8039 mL
DMSO	50 mM	0.0577 mL	0.2886 mL	0.5773 mL	1.4431 mL
	60 mM	0.0481 mL	0.2405 mL	0.4810 mL	1.2026 mL
	80 mM	0.0361 mL	0.1804 mL	0.3608 mL	0.9020 mL
	100 mM	0.0289 mL	0.1443 mL	0.2886 mL	0.7216 mL

Keywords

Corticosterone

68 Cited Publications

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MedChemExpress（MCE）の使用を引用している文献 Corticosterone

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純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Corticosterone 関連分類

HY-B1618 関連分類