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ABT-737

71 Cited Publications
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Based on 71 publication(s) in Google Scholar

ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research.

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  • 純度: 99.64%
  • CAS 番号: 852808-04-9
  • 分子式: C42H45ClN6O5S2
  • 分子量:813.43
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • ABT-737 Chemical Structure
    ABT-737 構造式
  • Experimental Validation Results for ABT-737
  • Experimental Validation Results for ABT-737
  • Experimental Validation Results for ABT-737
  • Experimental Validation Results for ABT-737
  • Experimental Validation Results for ABT-737
  • Experimental Validation Results for ABT-737
  • Experimental Validation Results for ABT-737
CAS 番号: 852808-04-9
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  • ABT-737 Chemical Structure
    ABT-737 Chemical Structure
    1/16
  • 1/16

    ABT-737 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 25;16(1):1774. [Abstract]

    Customer Validation
     NIH-3T3 fibroblasts were pre-treated (45 h) with vehicle, VAL (10 µM) or ABT-737 (10 µM) and then with RSL3 (5 µM, 3 h). Immunofluorescence images (representative of ≥ 25 single cells, n = 3, scale bar: 20 µm) stained for 4-HNE, cleaved (cl.) caspase 3 and nuclei (DAPI) and stained cells (h, lower panels).

  • 1/16

    ABT-737 purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2023 Jul 10;41(7):1242-1260.e6. [Abstract]

    Customer Validation
     Immunofluorescence staining of FoxP3 and CD4 in tumorigenic KY-FDR lungs, at 8 weeks after tumor induction, after vehicle (A), DT (A′), or ABT-737 (25 mg/kg, once per week) (A″) treatment. Tumor lesions are defined by dashed lines.

  • 1/16

    ABT-737 purchased from MedChemExpress. Usage Cited in: Cell. 2022 Sep 1;185(18):3356-3374.e22. [Abstract]

    Customer Validation
     Immunoblot of endogenous ATF4, APAF1 and CASPASE9 in PC9 cells after transient expression of Cas9 and either sgNT, sgAPAF1 or sgCASPASE9. Cells were treated with ABT-737 1μM and S6 2μM for 6h.

  • 1/16

    ABT-737 purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2022 Jul;29(7):1318-1334. [Abstract]

    Customer Validation
     Immunoblot analysis showing release of soluble mitochondrial proteins into the cytosol after treatment with 25 μM m-3M3FBS or a combination of Bcl-2/Bcl-xL (5 μM ABT-737) and Mcl-1 (5 μM S63845) inhibitors for 20 and 40 min followed by digitonin permeabilization in HeLa cells. To synchronize the onset of MOMP, cells were primed with a sublethal dose of UV irradiation (5 mJ/cm2) 16 h prior to ABT-737 plus S63845 addition. Data are representative of n = 3 independent experiments.

  • 1/16

    ABT-737 purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2022 Jul;29(7):1318-1334. [Abstract]

    Customer Validation
     Confocal microscopy analysis showing release of the IMS proteins omi-mCherry (red) and the Matrix proteins mito-GCaMP3 (green) in HeLa cells after 10 min treatment with 5 μM ABT-737 or 25 μM m-3M3FBS. To synchronize the onset of MOMP, cells were primed with a sublethal dose of UV irradiation (5 mJ/cm2) 16 h prior to ABT-737 addition. Data are representative of n = 3 independent experiments. Scale bar = 40 μm.

  • 1/16

    ABT-737 purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2022 Jul;29(7):1318-1334. [Abstract]

    Customer Validation
     Cell death quantification of HeLa WT and Bax,Bak DKO cells after 6 h of treatment with 25 μM m-3M3FBS or 5 μM ABT-737 + 5 μM S63845 in combination (A/S) with 40 μM qVD and/or 40 μM Calpain Inhibitor III (Calp.i). Error bars represent the SD from the mean of triplicate samples. Error bars represent the SD from the mean of n = 3 independent experiments.

  • 1/16

    ABT-737 purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2019 Oct 1:461:102-111. [Abstract]

    Customer Validation
     Expression of active (cleaved) PARP and active (cleaved) Caspase-3 after 48h of treatment with AGS, 1 μM ABT-737 or 1 μM ABT-737 added to AGS as determined by Western blot. Floating cells are included in lysate.

  • ABT-737