AL-LAD
AL-LAD is a 5-HT2A receptor ligand with rat Ki values of 8.1 nM and 3.4 nM. AL-LAD mediates behavioral responses characteristic of serotonergic psychedelics. AL-LAD induces the head-twitch response in male C57BL/6J mice in an inverted-U-shaped dose-dependent manner. AL-LAD exhibits LSD-like behavioral effects in male C57BL/6J mice.
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- CAS 番号: 65527-61-9
- 分子式: C22H27N3O
- 分子量:349.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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5-HT2A Receptor 8.1 nM (Ki) |
5-HT2A Receptor 3.4 nM (Ki) |
AL-LAD exhibits high affinity for 5-HT2A receptors in rat frontal cortex homogenates, with Ki values of 8.1 nM (vs. [3H]ketanserin) and 3.4 nM (vs. [125I]-R-DOI)[1].
AL-LAD binds to D1 and D2 dopaminergic receptors in rat tissue homogenates with K0.5 values of 189 nM and 12.3 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 6−8 weeks old)[1]
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Dosage:25 µg/kg; 50 µg/kg; 100 µg/kg; 200 µg/kg; 400 µg/kg
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Administration:i.p.; single dose
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Result:Dose-dependently induced HTR with an inverted-U-shaped response; maximal response occurred at 200 μg/kg.
化学情報
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CAS 番号 65527-61-9
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分子量 349.47
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分子式 C22H27N3O
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SMILES
[H][C@@]1(CC2=CNC3=CC=CC4=C23)C4=C[C@H](CN1CC=C)C(N(CC)CC)=O
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別名
6-Allyl-6-nor-LSD
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AL-LAD 関連分類
HY-W743888 関連分類
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