BGC20-761
BGC20-761 is a selecvtive 5-HT6 and dopamine receptor antagonist (human receptor Ki values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 17375-63-2
- 分子式: C19H22N2O
- 分子量:294.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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5-HT2A Receptor |
5-HT6 Receptor |
Human 5-HT6 Receptor 20 nM (Ki) |
Human 5-HT2A Receptor 69 nM (Ki) |
Human D2 Receptor 140 nM (Ki) |
BGC20-761 has highly potent and selective 5-HT6 receptor antagonist activity; rat Ki values for other rats receptors: 5-HT2A (470 nM), 5-HT2C (675 nM), D2, D3, D4, DAT and SERT (>10,000 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Forty-two male 8-week-old Longe Evans rats and 12 male four-week-old SpragueeDawley rats[1]
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Dosage:2.5 mg/kg, 5 mg/kg and 10 mg/kg
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Administration:Administered (i.p.) immediately after the training session for the social recognition test
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Result:Administered alone did not show any difference in social recognition as compared to saline treated control animals. However, 5 mg/kg and 10 mg/kg reversed a Scopolamine induced deficit in social recognition.
化学情報
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CAS 番号 17375-63-2
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分子量 294.39
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分子式 C19H22N2O
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SMILES
CN(C)CCC1=C(C2=CC=CC=C2)NC3=C1C=C(OC)C=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BGC20-761 関連分類
HY-21995 関連分類
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