CW 008
Based on 2 publication(s) in Google Scholar
CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.15%
- CAS 番号: 1134613-19-6
- 分子式: C21H14F2N6O2
- 分子量:420.37
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 CW 008
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生物活性
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PKA |
化学情報
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CAS 番号 1134613-19-6
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性状 Solid
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分子量 420.37
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分子式 C21H14F2N6O2
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Color White to yellow
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SMILES
O=C(C1=CC=C(C=C1)F)NC2=NNC3=C2C=C(F)C(C4=C5C=C(OC)C=CN5N=C4)=N3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Metab
Gut microbiota-derived isovaleric acid alleviates atrial fibrillation by suppressing GSDME-dependent pyroptosis. [Abstract]2026 Feb 3;38(2):370-387.e10. PMID: 41638192 -
Mol Carcinog
Adipocytes Promote Endometrial Cancer Progression Through Activation of the SIRT1-HMMR Signaling Axis. [Abstract]2024 Dec;63(12):2363-2381. PMID: 39254492
溶剤 & 溶解度
DMSO : 16.67 mg/mL (39.66 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3789 mL | 11.8943 mL | 23.7886 mL | 59.4714 mL |
| 5 mM | 0.4758 mL | 2.3789 mL | 4.7577 mL | 11.8943 mL | |
| 10 mM | 0.2379 mL | 1.1894 mL | 2.3789 mL | 5.9471 mL | |
| 15 mM | 0.1586 mL | 0.7930 mL | 1.5859 mL | 3.9648 mL | |
| 20 mM | 0.1189 mL | 0.5947 mL | 1.1894 mL | 2.9736 mL | |
| 25 mM | 0.0952 mL | 0.4758 mL | 0.9515 mL | 2.3789 mL | |
| 30 mM | 0.0793 mL | 0.3965 mL | 0.7930 mL | 1.9824 mL |
CW 008 関連分類
HY-110218 関連分類
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