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製品番号: HY-182676

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DC541

DC541 (Compound 20) is a selective NTMT1 inhibitor with an IC₅₀ of 0.34 μM. DC541 reduces the level of me3-RCC1 in colorectal cancer cells. DC541 is applicable to research related to colorectal cancer.

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CAS 番号: 2606862-00-2
分子式: C₃₀H₃₅N₅O₄
分子量:529.63

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

DC541 構造式

CAS 番号: 2606862-00-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Histone Methyltransferase アイソフォーム固有の製品をすべて表示 :

体外実験

DC541 potently inhibits purified NTMT1 with an IC₅₀ of 0.34 μM^[1].
DC541 (0.3-300 μM) inhibits the level of me3-RCC1 in colorectal cancer HT29 cells, with an IC₅₀ of approximately 30 μM^[1].
DC541 (0.3-300 μM) inhibits the level of me3-RCC1 in colorectal cancer HCT116 cells, with an IC₅₀ of approximately 100 μM^[1].
DC541 (up to 1 mM; 24-72 h) exerts no significant cytotoxicity against colorectal cancer HT29 and HCT116 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

human colorectal cancer HT29 and HCT116 cells
Concentration:

up to 1 mM
Incubation Time:

24-72 h
Result:

Showed no significant reduction in cell viability in HT29 cells at concentrations up to 1 mM across 24 h, 48 h, 72 h incubation time points.
Showed no significant reduction in cell viability in HCT116 cells at concentrations up to 1 mM across 24 h, 48 h, 72 h incubation time points.

化学情報

CAS 番号 2606862-00-2
分子量 529.63
分子式 C₃₀H₃₅N₅O₄
SMILES

O=C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(NC2=C(C=CC=C2)C(N)=O)=O)=O)CC3=CC=CC4=C3C=CC=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Chen D, et al. Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltransferase 1. ACS Med Chem Lett. 2021;12(3):485-493. Published 2021 Mar 1. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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DC541

Histone Methyltransferase アイソフォーム固有の製品をすべて表示