FL113
FL113 is a racemate of FL118 (HY-12486). FL113 is less effective than FL118 in inhibiting the expression of Survivin, Mcl-1, XIAP, and cIAP2. FL113 exhibits weaker antitumor activity than FL118 in colon tumor xenograft models. FL113 can be used for research on colon cancer and head and neck cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 104155-89-7
- 分子式: C21H16N2O6
- 分子量:392.37
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
Mcl-1 |
XIAP |
cIAP2 |
体外実験
FL113 (10 nM; 48-96 h) is far less effective than FL118 (HY-12486) in inhibiting the expression of survivin, Mcl-1, XIAP, and cIAP2 in head and neck FaDu cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:FaDu
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Concentration:10 nM
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Incubation Time:48, 72, and 96 h
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Result:Inhibited survivin, Mcl-1, XIAP, and cIAP2 protein expression less effectively than FL118.
体内実験
FL113 (1 mg/kg; weekly × 4 schedule) exhibits much weaker antitumor activity than FL118 in colon tumor xenograft models[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID mice (female, 6-12 weeks old)[1]
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Dosage:1.5 mg/kg
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Administration:i.p.; single injection
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Result:Resulted in less effective inhibition of survivin, Mcl-1, and cIAP2 expression compared to FL118.
Showed no inhibitory effect on XIAP in the in vivo tumor tissues.
化学情報
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CAS 番号 104155-89-7
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分子量 392.37
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分子式 C21H16N2O6
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SMILES
O=C1OCC=2C(=O)N3C(=CC2C1(O)CC)C=4N=C5C=C6OCOC6=CC5=CC4C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
FL113 関連分類
HY-187844 関連分類
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