PDGFRB - platelet derived growth factor receptor beta Gene

Also Known as IMF1; KOGS; IBGC4; JTK12; PDGFR; PENTT; CD140B; PDGFR1; PDGFR-1

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 5159

About PDGFRB

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:150,113,839-150,155,845 (from NCBI)

This gene has 11 transcripts (splice variants), 247 orthologues, 53 paralogues and is associated with 124 phenotypes. Broad expression in gall bladder (RPKM 79.5), placenta (RPKM 61.0) and 21 other tissues.

Summary

The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin Cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]

PDGFRB Products (4)

mRNA	Protein	Name
NR_149150.2
NM_001355016.2	NP_001341945.1	platelet-derived growth factor receptor beta isoform 2
NM_002609.4	NP_002600.1	platelet-derived growth factor receptor beta isoform 1 precursor
NM_001355017.2	NP_001341946.1	platelet-derived growth factor receptor beta isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	1653029	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	26315405	GOA
enables phospholipase C activator activity	IMP IMP: Inferred from mutant phenotype	1653029	GOA
enables platelet-derived growth factor beta-receptor activity	IDA IDA: Inferred from direct assay	1314164	GOA
enables platelet-derived growth factor beta-receptor activity	IMP IMP: Inferred from mutant phenotype	2554309	GOA
enables platelet-derived growth factor binding	IDA IDA: Inferred from direct assay	2554309	GOA
enables platelet-derived growth factor binding	IPI IPI: Inferred from physical interaction	2536956	GOA
enables platelet-derived growth factor receptor binding	IPI IPI: Inferred from physical interaction	2542288	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1314164	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	1314164	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16479011	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	1653029	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	10821867	GOA
enables vascular endothelial growth factor binding	IPI IPI: Inferred from physical interaction	17470632	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in cell chemotaxis	IDA IDA: Inferred from direct assay	2554309	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	2536956	GOA
involved in platelet-derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	1314164	GOA
involved in platelet-derived growth factor receptor-beta signaling pathway	IMP IMP: Inferred from mutant phenotype	2554309	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21679854	GOA
involved in positive regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	2554309	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	17470632	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	2554309	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	2554309	GOA
involved in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	17470632	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	1314164	GOA
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	21679854	GOA
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	21679854	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	2536956	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	10821867	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in membrane	IDA IDA: Inferred from direct assay	16477012	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	2554309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDGFRB Protein Structure

Ig_2

I-set

Pkinase_Tyr

0
200
400
600
800
1000
1106 a.a.

Protein Preferred Names	Protein Names
platelet-derived growth factor receptor beta	Activated tyrosine kinase PDGFRB CD140 antigen-like family member B NDEL1-PDGFRB PDGF-R-beta PDGFR-beta beta-type platelet-derived growth factor receptor platelet-derived growth factor receptor 1 platelet-derived growth factor receptor, beta polypeptide

PDGFRB Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	PDGFRB	P09619	KDR	Homo sapiens	P35968	Anti Bait CoIP	18997771
Intra	PDGFRB	P09619	KRTAP10-9	Homo sapiens	P60411	Y2H Array	32296183
Intra	PDGFRB	P09619	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	32296183
Intra	PDGFRB	P09619	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	32296183
Intra	PDGFRB	P09619	RASA1	Homo sapiens	P20936	CoIP	1314164
Intra	PDGFRB	P09619	RASA1	Homo sapiens	P20936	CoIP	1375321
Intra	PDGFRB	P09619	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	PDGFRB	P09619	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	PDGFRB	P09619	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
Intra	PDGFRB	P09619	KPRP	Homo sapiens	Q5T749	Y2H Array	32296183
Intra	PDGFRB	P09619	KPRP	Homo sapiens	Q5T749	Y2H Prey Pooling	32296183
Intra	PDGFRB	P09619	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	PDGFRB	P09619	KRTAP12-3	Homo sapiens	P60328	Validated Y2H	32296183
Intra	PDGFRB	P09619	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	PDGFRB	P09619	PDGFB	Homo sapiens	P01127	Competition Binding	7679113
Intra	PDGFRB	P09619	PDGFB	Homo sapiens	P01127	ELISA	7679113
Intra	PDGFRB	P09619	PDGFB	Homo sapiens	P01127	Crosslink	11297552
Intra	PDGFRB	P09619	PDGFB	Homo sapiens	P01127	Competition Binding	10806482
Cross	PDGFRB	P09619	Kdr	Mus musculus	P35918	Anti Tag CoIP	18997771
Cross	PDGFRB	P09619	Kdr	Mus musculus	P35918	Anti Bait CoIP	18997771
Intra	PDGFRB	P09619	PTPRJ	Homo sapiens	Q12913	Phosphatase Assay	10821867
Intra	PDGFRB	P09619	PTPRJ	Homo sapiens	Q12913	CoIP	10821867
Intra	PDGFRB	P09619	PTPRJ	Homo sapiens	Q12913	Biochemical	10821867
Intra	PDGFRB	P09619	PTPN12	Homo sapiens	Q05209	Phosphatase Assay	19167335
Intra	PDGFRB	P09619	PTPN12	Homo sapiens	Q05209	BiFC	21376233
Intra	PDGFRB	P09619	LRIG2	Homo sapiens	O94898	Anti Bait CoIP	30015847
Intra	PDGFRB	P09619	LRIG2	Homo sapiens	O94898	Confocal	30015847
Intra	PDGFRB	P09619	LRIG2	Homo sapiens	O94898	Anti Tag CoIP	30015847
Intra	PDGFRB	P09619	PTPN11	Homo sapiens	Q06124	Anti Bait CoIP	7688466
Intra	PDGFRB	P09619	PTPN11	Homo sapiens	Q06124	PLA	23397142
Intra	PDGFRB	P09619	PTPN11	Homo sapiens	Q06124	X-Ray Diffraction	8538796
Intra	PDGFRB	P09619	PTPN11	Homo sapiens	Q06124	SPR	7530043
Intra	PDGFRB	P09619	NHERF1	Homo sapiens	O14745	PLA	23397142
Intra	PDGFRB	P09619	NHERF1	Homo sapiens	O14745	Pull Down	24012959
Intra	PDGFRB	P09619	NHERF1	Homo sapiens	O14745	Filter Binding	16456542
Intra	PDGFRB	P09619	FYN	Homo sapiens	P06241	Pull Down	7685273
Intra	PDGFRB	P09619	PTEN	Homo sapiens	P60484	Pull Down	24012959
Cross	PDGFRB	P09619	E5	Bovine papillomavirus	P0CK45	CoIP	1334459
Intra	PDGFRB	P09619	SLA	Homo sapiens	Q13239	Pull Down	9742401
Intra	PDGFRB	P09619	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	25416956
Intra	PDGFRB	P09619	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	32296183
Intra	PDGFRB	P09619	KLHL12	Homo sapiens	Q53G59	Validated Y2H	32296183
Intra	PDGFRB	P09619	KLHL12	Homo sapiens	Q53G59	Y2H Array	32296183
Intra	PDGFRB	P09619	TRIP6	Homo sapiens	Q15654	Validated Y2H	25416956
Intra	PDGFRB	P09619	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	25416956
Intra	PDGFRB	P09619	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	PDGFRB	P09619	CEP76	Homo sapiens	Q8TAP6	Validated Y2H	32296183
Intra	PDGFRB	P09619	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
Intra	PDGFRB	P09619	PLCG1	Homo sapiens	P19174	PLA	23397142
Intra	PDGFRB	P09619	PLCG1	Homo sapiens	P19174	Affinity Chrom	35384245
Intra	PDGFRB	P09619	PLCG1	Homo sapiens	P19174	CoIP	1396585
Intra	PDGFRB	P09619	PIK3R1	Homo sapiens	P27986	CD	1330535
Intra	PDGFRB	P09619	PIK3R1	Homo sapiens	P27986	CoIP	1314164
Intra	PDGFRB	P09619	PIK3R1	Homo sapiens	P27986	PLA	19864249
Intra	PDGFRB	P09619	PIK3R1	Homo sapiens	P27986	BioID	35384245
Intra	PDGFRB	P09619	PIK3R1	Homo sapiens	P27986	NMR	8382612
Intra	PDGFRB	P09619	PIK3R1	Homo sapiens	P27986	Y2H	11710529
Intra	PDGFRB	P09619	PIK3R1	Homo sapiens	P27986	Pull Down	9153411
Intra	PDGFRB	P09619	PIK3R1	Homo sapiens	P27986	Fluorescence Spectr	1330535
Intra	PDGFRB	P09619	PIK3R1	Homo sapiens	P27986	Anti Tag CoIP	33961781
Intra	PDGFRB	P09619	PIK3R1	Homo sapiens	P27986	Biophysical	1330535
Intra	PDGFRB	P09619	LRP6	Homo sapiens	O75581	Anti Bait CoIP	21245321
Intra	PDGFRB	P09619	LRP6	Homo sapiens	O75581	Anti Tag CoIP	21245321
Intra	PDGFRB	P09619	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	PDGFRB	P09619	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	PDGFRB	P09619	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	PDGFRB	P09619	PTPN1	Homo sapiens	P18031	Affinity Techniques	12614164
Intra	PDGFRB	P09619	PTPN1	Homo sapiens	P18031	Anti Tag CoIP	9355745
Intra	PDGFRB	P09619	PTPN1	Homo sapiens	P18031	Phosphatase Assay	19167335
Intra	PDGFRB	P09619	GRB7	Homo sapiens	Q14451	Competition Binding	8940081
Intra	PDGFRB	P09619	GRB7	Homo sapiens	Q14451	Pull Down	8940081
Cross	PDGFRB	P09619	PIK3R1	Bos taurus	P23727	CoIP	8382774
Cross	PDGFRB	P09619	PIK3R1	Bos taurus	P23727	Competition Binding	9512716
Cross	PDGFRB	P09619	PIK3R1	Bos taurus	P23727	SPR	10336465
Cross	PDGFRB	P09619	PIK3R1	Bos taurus	P23727	SPR	7683666
Cross	PDGFRB	P09619	Ptpn11	Rattus norvegicus	P41499	Pull Down	31585087
Cross	PDGFRB	P09619	V-SRC	Rous sarcoma virus	P25020	ITC	12706723
Cross	PDGFRB	P09619	V-SRC	Rous sarcoma virus	P25020	X-Ray Diffraction	12706723

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDGFRB Proteins

製品番号	製品名	アクセッション番号	純度
HY-P72494	PDGFRB Protein, Human (HEK293, His)	NP_002600.1 (L33-K531)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77123	PDGFRB Protein, Human (HEK293, His-Avi)	P09619-1 (L33-F530)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77124	PDGFRB Protein, Human (HEK293, Fc)	NP_002600.1 (L33-F530)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77127	PDGFRB Protein, Human (Biotinylated, HEK293, His)	NP_002600.1 (L33-K531)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78194	PDGF R beta Protein, Human (Biotinylated, HEK293, His-Avi)	P09619-1 (L33-F530)	≥ 95%, as determined by Bis-Tris PAGE.

PDGFRB 抗体

製品番号	製品名	アプリケーション	反応性
HY-P80278	Phospho-PDGFR beta (Y740) Antibody (YA164)	WB, ICC/IF	Human, Rat
HY-P810635	Phospho-PDGFR beta (Tyr751) Antibody (YA9897)	WB	Human, Mouse, Rat
HY-P810636	Phospho-PDGFR beta (Tyr1009) Antibody (YA9898)	WB	Human, Mouse, Rat
HY-P82180	PDGFR beta Antibody (YA1925)	WB, IP	Human, Mouse, Rat
HY-P82180A	PDGFR beta Antibody (YA1925)(PBS only)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P83317	Phospho-PDGFR beta (Tyr740) Antibody (YA3062)	WB, ICC/IF	Mouse, Rat
HY-P83737	PDGFR beta Antibody (YA3467)	WB, IHC-P, IHC-F, ICC/IF, IP, FC, IF-Tissue, mIHC	Human, Mouse, Rat
HY-P84032	PDGFR beta Antibody (YA3729)	WB, ELISA	Human, Mouse
HY-P84032A	PDGFR beta Antibody (YA3729)(PBS only)	WB, ELISA	Human, Mouse
HY-P85320	PDGFR beta Antibody (YA5012)	WB; IHC-P; IF-Tissue; IHC-F	Human, Mouse, Rat
HY-P86327	PDGFR beta Antibody (YA6019)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P87029	Phospho-PDGFR beta (Y1021) Antibody (YA6722)	WB	Mouse

関連疾患

Diseases	Alias
Hematologic Cancer	Hematologic Neoplasm Hematologic Malignancies Hematologic Neoplasms Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Adult Malignant Schwannoma	Adult Mpnst Adult Neurofibrosarcoma
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Endomyocardial Fibrosis	Becker'S Disease Obscure African Cardiomyopathy African Endomyocardial Fibrosis Endomyocardial Sclerosis EMF Becker Muscular Dystrophy
Aggressive Systemic Mastocytosis	Asm Lymphadenopathic Mastocytosis With Eosinophilia
Rhabdomyosarcoma
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Castleman Disease	Angiofollicular Ganglionic Hyperplasia Angiofollicular Lymph Hyperplasia Giant Lymph Node Hyperplasia Castleman'S Disease Angiofollicular Lymph Node Hyperplasia Lymphoid Hamartoma Benign Giant Lymphoma Angiolymphoid Hyperplasia
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma Primitive Neuroectodermal Tumor ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Ewing Family Of Tumors Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Basal Ganglia Calcification, Idiopathic, 1	Primary Familial Brain Calcification Pfbc Bspdc Bilateral Striopallidodentate Calcinosis Cerebrovascular Ferrocalcinosis IBGC1 Idiopathic Basal Ganglia Calcification 1 Striopallidodentate Calcinosis, Bilateral Striopallidodentate Calcinosis, Autosomal Dominant, Adult-Onset Cerebral Calcification, Nonarteriosclerotic, Idiopathic, Adult-Onset Ferrocalcinosis, Cerebrovascular Fahr Disease, Familial, Formerly Basal Ganglia Calcification, Idiopathic, 3, Formerly Ibgc3, Formerly Basal Ganglia Calcification, Idiopathic, 2, Formerly Ibgc2, Formerly Familial Idiopathic Basal Ganglia Calcification Fibgc Striopallidodentate Calcinosis Idiopathic Basal Ganglia Calcification Ferrocalcinosis Cerebro Vascular Autosomal Dominant Adult-Onset Striopallidodentate Calcinosis Familial Fahr Disease Ibgc2 Ibgc3 Idiopathic Basal Ganglia Calcification 2 Idiopathic Basal Ganglia Calcification 3 Non-Arteriosclerotic, Idiopathic, Adult-Onset Cerebral Calcification Basal Ganglia Calcification, Idiopathic Calcification, Basal Ganglia, Idiopathic Calcification, Basal Ganglia, Idiopathic, Type 1 Fahr'S Syndrome
Basal Ganglia Calcification	Fahr'S Syndrome Fahr'S Disease Fahr Disease
Leiomyosarcoma	Leiomyosarcomas
Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative	Atypical Chronic Myeloid Leukaemia Atypical Chronic Myeloid Leukemia Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Acml Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Atypical Cml Subacute Myeloid Leukemia Subacute Myelogenous Leukaemia Subacute Myeloid Leukaemia Subacute Myelosis Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission Subacute Monocytic Leukaemia Without Mention Of Remission Subacute Monocytic Leukaemia
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Infantile Myofibromatosis	Lipofibromatosis Myofibromatosis
Premature Aging	Syndrome With Premature-Aging
Overgrowth Syndrome	Overgrowth Congenital Malformation Syndromes Involving Early Overgrowth
Desmoid Tumor	Aggressive Fibromatosis Desmoid Type Fibromatosis Familial Infiltrative Fibromatosis Desmoid Disorder, Hereditary Fif Fibromatosis, Familial Infiltrative Deep Fibromatosis Desmoid Fibromatosis Hereditary Desmoid Disease Musculoaponeurotic Fibromatosis Desmoid-Type Fibromatosis Fibromatosis, Aggressive Desmoid Disease, Hereditary Musculo-Aponeurotic Fibromatosis
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Endometrial Stromal Sarcoma	Ess Endometrial Stromal Sarcoma, High Grade Undifferentiated Endometrial Sarcoma Stromal Sarcoma Of The Corpus Uteri Sarcoma Endometrial Stromal Sarcoma, Endometrial Stromal Undifferentiated Stromal Sarcoma
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Myeloid And Lymphoid Neoplasms With Eosinophilia And Abnormalities Of Pdgfra, Pdgfrb, And Fgfr1	Myeloid And Lymphoid Neoplasms With Eosinophilia And Abnormalities Of Platelet-Derived Growth Factor Receptor Alpha , Platelet-Derived Growth Factor Receptor Beta , And Fibroblast Growth Factor Receptor-1 Are A Group Of Hematologic Neoplasms Myeloid And Lymphoid Neoplasms With Eosinophilia And Rearrangement Of Pdgfra, Pdgfrb, Or Fgfr1, Or With Pcm1-Jak2
Vascular Cancer	Blood Vessel Tumors Malignant Vascular Neoplasm Renal Vein Leiomyosarcoma Vascular Neoplasms Blood Vessel Neoplasm Blood Vessel Tumor Blood Vessel Tumour Disorder Haemangiomatous Tumour Leiomyosarcoma Of The Renal Vein Malignant Great Vessel Tumor Malignant Tumor Of Pulmonary Artery Malignant Tumor Of Pulmonary Vein Malignant Vascular Tumor Neoplasm Of Great Vessel Pulmonary Artery Malignant Neoplasm Pulmonary Vein Malignant Neoplasm Vascular Tissue Neoplasm Vascular Tumors Blood Vessel Cancer Neoplasms, Vascular Tissue Malignant Neoplasm Of Great Vessels
Dandy-Walker Syndrome	Dandy-Walker Malformation DWS Atresia Of Foramina Of Magendie And Luschka Dandy-Walker Complex Dandy-Walker Deformity Dandy Walker Cyst Dw Complex Dandy-Walker Syndrome Or Malformation Dandy-Walker Variant Mega Cisterna Magna Dandy-Walker Cyst Dwm Hydrocephalus, Internal, Dandy-Walker Type Hydrocephalus, Noncommunicating, Dandy-Walker Type Luschka-Magendie Foramina Atresia Isolated Dandy-Walker Malformation Mega-Cisterna Magna Dandy Walker Variant Atresia Of Foramen Of Luschka Atresia Of Foramen Of Magendie Congenital Blockage Of Foramen Magendie
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Pilocytic Astrocytoma	Juvenile Pilocytic Astrocytoma Grade I Astrocytic Tumor Piloid Astrocytoma
Malignant Fibrous Histiocytoma	Undifferentiated Pleomorphic Sarcoma Ups Fibroxanthosarcoma Mfh Malignant Fibrohistiocytic Tumors Histiocytoma, Malignant Fibrous Histiocytoma, Fibrous, Malignant
Tenosynovial Giant Cell Tumor	Fibrous Histiocytoma Of Tendon Sheath Giant Cell Tumor Of Tendon Sheath Giant Cell Tumor Of Tenosynovium Giant Cell Tumour Of Tendon Sheath Giant Cell Tumour Of Tenosynovium Tenosynovial Giant Cell Tumour Diffuse-Type Gct Diffuse-Type Giant Cell Tumor Pigmented Villonodular Synovitis Tgct Tsgct
Mesenchymal Cell Neoplasm	Benign Miscellaneous Mesenchymal Tumor Mesenchymal Tumor Mesenchymal Tumors
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Chronic Leukemia	Adult Chronic Leukemia Cll Cml
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Familiar Ovarian Carcinoma
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Tibial Adamantinoma	Tibial Adamantinoma Morphology
Basal Ganglia Calcification, Idiopathic, 4	IBGC4 Calcification, Basal Ganglia, Idiopathic, Type 4
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Cryptogenic Fibrosing Alveolitis Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Brain Cancer	Malignant Neoplasm Of Brain Adult Brain Tumor Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Primary Hypereosinophilic Syndrome	Clonal Hypereosinophilic Syndrome Hes-M Hes-N Neoplastic Hypereosinophilic Syndrome Primary Hes Hm Syndrome
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma
Neurilemmoma	Schwannoma Benign Schwannoma Neurilemoma Peripheral Fibroblastoma Psammomatous Schwannoma Neurolemmoma Schwannomas
Aging
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Parkinsonism	Parkinsonism-Plus Idiopathic Parkinsonism Primary Parkinsonism Paralysis Agitans Syndrome Parkinsonian Syndrome Trembling Paralysis Paralysis Agitans Shaking Palsy Shaking Paralysis
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Myofibromatosis, Infantile, 1	IMF1 Fibromatosis, Congenital Generalized Cgf Congenital Generalized Fibromatosis Myofibromatosis, Juvenile Myofibromatosis, Infantile 1 Juvenile Myofibromatosis Myofibromatosis, Infantile, Type 1 Infantile Myofibromatosis Myofibromatosis
Mesothelioma, Malignant	Malignant Mesothelioma Pleural Mesothelioma MESOM Mesothelioma, Somatic Advanced Malignant Mesothelioma Asbestos-Related Malignant Mesothelioma Diffuse Malignant Mesothelioma Malignant Tumor Of Mesothelium Malignant Mesothelioma, Susceptibility To Mesothelioma Diffuse Malignant Mesothelioma Malignant Pleural Mesothelioma
Hypereosinophilic Syndrome	Eosinophilia HES Eosinophilic Leukocytosis Hypereosinophilic Syndrome, Idiopathic Idiopathic Hypereosinophilic Syndrome Disseminated Eosinophilic Collagen Disease Eosinophilic Disorder Disorders With Increased Eosinophil Counts
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Mastocytosis	Mast Cell Disease Mast Cell Hyperplasia Urticaria Pigmentosa Malignant Mastocytoma Malignant Mast Cell Tumours Malignant Mastocytosis
Hypereosinophilic Syndrome, Idiopathic	Idiopathic Hypereosinophilic Syndrome Hypereosinophilic Syndrome, Idiopathic, Resistant To Imatinib HES
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Basal Ganglia Disease	Basal Ganglia Diseases Basal Ganglia Disorders Abnormality Of The Basal Ganglia
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Uterine Sarcoma	Sarcoma Of The Uterus Uterine Corpus Sarcoma
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Hemangioblastoma	Capillary Hemangioblastoma
Myofascial Pain Syndrome	Myofascial Pain Syndromes Myofascial Pain Dysfunction Syndrome Fibromyalgia
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Costello Syndrome	Faciocutaneoskeletal Syndrome Fcs Syndrome Congenital Myopathy With Excess Of Muscle Spindles CSTLO CMEMS Fcss Myopathy, Congenital, With Excess Of Muscle Spindles
Arteriosclerosis	Arteriosclerotic Vascular Disease
Chronic Eosinophilic Leukemia	Pdgfra-Associated Chronic Eosinophilic Leukemia
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Connective Tissue Benign Neoplasm	Soft Tissue Neoplasms Mesenchymal Tissue Neoplasm Neoplasm Of Soft Tissue Neoplasm Of Soft Tissues Soft Tissue Benign Neoplasm Tumor Of The Soft Tissue Soft Tissue Neoplasm
Myofibroma	Lipoleiomyoma Uterine Fibroids Solitary Myofibromatosis Myolipoma
Anaplastic Astrocytoma	Grade Iii Astrocytoma Grade Iii Astrocytic Tumor Astrocytoma, Anaplastic
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Myelodysplastic/Myeloproliferative Neoplasm	Myelodysplastic/Myeloproliferative Disease Myelodysplastic-Myeloproliferative Diseases Myelodysplastic Myeloproliferative Cancer Myelodysplastic Myeloproliferative Disease Myeloproliferative/Myelodysplastic Syndromes
Paraganglioma And Gastric Stromal Sarcoma	Carney-Stratakis Syndrome Paraganglioma And Gastrointestinal Stromal Tumor Carney Dyad Carney-Stratakis Dyad Of Paraganglioma And Gastric Stromal Sarcoma Paraganglioma And Gist Carney-Stratakis Dyad Gist-Paraganglioma Dyad PGGSS Paraganglioma, Gastric Stromal Sarcoma Gastrointestinal Stromal Tumors
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Myeloid And Lymphoid Neoplasms Associated With Pdgfrb Rearrangement	Myeloid And Lymphoid Neoplasms With Pdgfrb Rearrangement Myeloid/Lymphoid Neoplasm Associated With Pdgfrb Rearrangement
Premature Aging Syndrome, Penttinen Type	Acroosteolysis-Keloid-Like Lesions-Premature Aging Syndrome Penttinen-Aula Syndrome PENTT Penttinen Syndrome Premature Aging Syndrome Penttinen Type Prematurely Aged Appearance, Delayed Bone Maturation, Acro-Osteolysis, And Brachydactyly Aging, Premature, Syndrome, Penttinen Type
Systemic Mastocytosis	Systemic Mast Cell Disease Systemic Tissue Mast Cell Disease Mastocytosis, Systemic Smcd - Systemic Mast Cell Disease Smcd Mast Cell Disease, Systemic Systemic Mast-Cell Disease Systemic Mastocytoses Mastocytosis Systemic Corneal Dystrophy, Subepithelial Mucinous Smcd - [Systemic Mast Cell Disease]
Moyamoya Disease 1	Moyamoya Disease Spontaneous Occlusion Of The Circle Of Willis Mymy Progressive Intracranial Arterial Occlusion Moyamoya Syndrome MYMY1 Cerebrovascular Moyamoya Disease Moya-Moya Disease Progressive Intracranial Occlusive Arteropathy Idiopathic Moyamoya Disease
Myeloproliferative Disorder, Chronic, With Eosinophilia	Myeloproliferative Disorder With Eosinophilia MPE Emp Eosinophils, Malignant Proliferation Of Chronic Myeloproliferative Disorder With Eosinophilia Chronic Myeloproliferative Disease, Unclassifiable Cmpd-U Undifferentiated Myeloproliferative Disease Myeloproliferative Disorder Chronic With Eosinophilia Malignant Proliferation Of Eosinophils Myeloproliferative Neoplasm, Unclassifiable
Chordoma	CHDM Notochordoma Notochordal Sarcoma Chordoma, Susceptibility To Chordocarcinoma Chordoepithelioma
Renal Fibrosis
Kosaki Overgrowth Syndrome	Skeletal Overgrowth-Craniofacial Dysmorphism-Hyperelastic Skin-White Matter Lesions Syndrome KOGS Skeletal Overgrowth With Facial Dysmorphism, Hyperelastic Skin, White Matter Lesions, And Neurologic Deterioration
Myeloid And Lymphoid Neoplasms Associated With Pdgfra Rearrangement	Myeloid/Lymphoid Neoplasm Associated With Pdgfra Rearrangement Myeloid And Lymphoid Neoplasms With Pdgfra Rearrangement
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Localized Osteosarcoma	Localised Osteogenic Sarcoma Localised Osteosarcoma Localized Osteogenic Sarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Phase
HY-132166	Velzatinib	Inhibitor	99.40%	Phase 3

Pre-clinical Phase

Bioactive Molecules (6)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-15813	FIIN-1	Inhibitor	99.04%	Unkown
HY-RS10257	PDGFRB Human Pre-designed siRNA Set A		/	Unkown
HY-115541	BRD4-IN-41	Inhibitor	/	Unkown
HY-RS10258	Pdgfrb Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS10259	Pdgfrb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174548	Human PDGFRB mRNA		/	Unkown

阻害性抗体 (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-P992326	BOT1711	Inhibitor	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	PDGFRB	VGNC	VGNC:75929
Rattus norvegicus	PDGFRB	RGD	RGD:3285
Bos taurus	PDGFRB	VGNC	VGNC:32693
Canis familiaris	PDGFRB	VGNC	VGNC:44373
Mus musculus	PDGFRB	MGD	MGI:97531
Felis catus	PDGFRB	VGNC	VGNC:68772
Others	PDGFRB	NCBI