Glutarimide
Based on 1 Customer Validation
Glutarimide is a CRBN binder. Glutarimide exerts its function by binding to the thalidomide-binding domain of the CRBN protein. Glutarimide serves as an important structural component of many biologically active compounds. Glutarimide can be used in studies related to anemia, multiple myeloma and cycloheximide.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.0%
- CAS 番号: 1121-89-7
- 分子式: C5H7NO2
- 分子量:113.11
-
保管条件:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Calcium Channel アイソフォーム固有の製品をすべて表示
More
生物活性
製品説明
IC50 & Target
[1]|
Cereblon |
体外実験
Glutarimide is the CRBN-binding motif that mediates the interaction between CELMoD and the thalidomide-binding domain of CRBN[1].
Glutarimide does not inhibit carbachol (HY-B1208)-induced calcium mobilization in neuroblastoma SK-N-SH cells at concentrations up to 120 μM, with an IC50 > 120 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
化学情報
-
CAS 番号 1121-89-7
-
性状 Solid
-
分子量 113.11
-
分子式 C5H7NO2
-
Color White to off-white
-
SMILES
O=C(CCC1)NC1=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (442.05 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (273 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Szewczyk SM, et al. Trends in Neosubstrate Degradation by Cereblon-Based Molecular Glues and the Development of Novel Multiparameter Optimization Scores. J Med Chem. 2024 Jan 25;67(2):1327-1335. [Content Brief]
[2]. Nakae K, et al. Migrastatin acts as a muscarinic acetylcholine receptor antagonist. The Journal of antibiotics. 2006 Nov;59(11):685-92. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 8.8410 mL | 44.2048 mL | 88.4095 mL | 221.0238 mL |
| 5 mM | 1.7682 mL | 8.8410 mL | 17.6819 mL | 44.2048 mL | |
| 10 mM | 0.8841 mL | 4.4205 mL | 8.8410 mL | 22.1024 mL | |
| 15 mM | 0.5894 mL | 2.9470 mL | 5.8940 mL | 14.7349 mL | |
| 20 mM | 0.4420 mL | 2.2102 mL | 4.4205 mL | 11.0512 mL | |
| 25 mM | 0.3536 mL | 1.7682 mL | 3.5364 mL | 8.8410 mL | |
| 30 mM | 0.2947 mL | 1.4735 mL | 2.9470 mL | 7.3675 mL | |
| 40 mM | 0.2210 mL | 1.1051 mL | 2.2102 mL | 5.5256 mL | |
| 50 mM | 0.1768 mL | 0.8841 mL | 1.7682 mL | 4.4205 mL | |
| 60 mM | 0.1473 mL | 0.7367 mL | 1.4735 mL | 3.6837 mL | |
| 80 mM | 0.1105 mL | 0.5526 mL | 1.1051 mL | 2.7628 mL | |
| 100 mM | 0.0884 mL | 0.4420 mL | 0.8841 mL | 2.2102 mL |
Glutarimide 関連分類
HY-I0466 関連分類
Powered by Bioz