GPR
GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 47295-77-2
- 分子式: C13H24N6O4
- 分子量:328.37
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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生物活性
製品説明
体外実験
GPR (1-100 μM; 24 h, 48 h) prevented Aβ-mediated increase in lactate dehydrogenase (LDH) release[1].
GPR (50 μM; 24 h, 48 h) prevents Ah-mediated inhibition of neuronal MTT reduction[1].
GPR (50 μM; 3 days) prevents Aβ-mediated increase in p53-positive cells[1].
GPR (50 μM; 24 h) effectively prevented the Aβ-mediated activation of caspase-3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:p53-positive cells
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Concentration:50 μM
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Incubation Time:3 days
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Result:Inhibited Ah-induced increase in numbers of p53-positive neurons.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 47295-77-2
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分子量 328.37
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分子式 C13H24N6O4
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シーケンスの短縮
GPR
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GPR 関連分類
HY-P3528 関連分類
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