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GTS-21

16 Cited Publications
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Based on 16 publication(s) in Google Scholar

GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti inflammatory and cognition enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist. GTS-21 can be used in age-associated memory impairment (AAMI) and Alzheimer's disease research.

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  • CAS 番号: 148372-04-7
  • 分子式: C19H20N2O2
  • 分子量:308.37
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • GTS-21 Chemical Structure
    GTS-21 構造式
  • Experimental Validation Results for GTS-21
  • Experimental Validation Results for GTS-21
  • Experimental Validation Results for GTS-21
  • Experimental Validation Results for GTS-21
  • Experimental Validation Results for GTS-21
CAS 番号: 148372-04-7
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  • GTS-21 Chemical Structure
    GTS-21 Chemical Structure
    1/16
  • 1/16

    GTS-21 purchased from MedChemExpress. Usage Cited in: Diabetologia. 2025 Dec 15. [Abstract]

    Customer Validation
     HTR8/SVneo cells were treated with nicotine (NT), PNU or GTS-21 dihydrochloride (1 μM) at different concentrations (0, 0.1, 1, 10 μM) for 24 h under HG. Western blot images and quantification of p-p66Shc and p21 relative to GAPDH.

  • 1/16

    GTS-21 purchased from MedChemExpress. Usage Cited in: Diabetologia. 2025 Dec 15. [Abstract]

    Customer Validation
     HTR8/SVneo cells or primary feeder cells were treated with normal glucose (NG), high glucose (HG), high glucose + PNU, or high glucose + GTS-21 dihydrochloride (1 μM), respectively. Mitochondrial membrane potential (MMP) was analyzed by flow cytometry using JC-1 staining.

  • 1/16

    GTS-21 purchased from MedChemExpress. Usage Cited in: Diabetologia. 2025 Dec 15. [Abstract]

    Customer Validation
     HTR8/SVneo cells or primary trophoblast cells were treated with normal glucose (NG), high glucose (HG), high glucose + PNU, or high glucose + GTS-21 dihydrochloride (1 μM), respectively. Representative confocal microscopy images of mitochondrial permeability transition pore (mPTP) opening experiments quenched with calcein AM (green) and cobalt chloride (CoCl₂).

  • 1/16

    GTS-21 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2022 Feb 8;8(1):54. [Abstract]

    Customer Validation
     Intraperitoneal injection of GTS-21 (4 mg/kg) significantly downregulated the expression of NLRP3, ASC, Cl-Caspase-1 and GSDMD-N.

  • 1/16

    GTS-21 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2022 May:149:112733. [Abstract]

    Customer Validation
     GTS-21 dihydrochloride (10 μM). The relative expression levels of ZO-1, Occludin, and Claudin-1 in Caco2 cells were analyzed by Western blot.

  • GTS-21