HF50731
Based on 1 Customer Validation
HF50731 (compound 21) is a potent CXCR4 antagonist. HF50731 shows strong CXCR4 binding affinity, with IC50 of 19.8 nM. HF50731 effectively inhibits calcium mobilization, cell migration, and HIV-1 infection via CXCR4 coreceptor, with IC50 values of 119.2 nM, 621.4 nM and 1.5 μM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.66%
- CAS 番号: 2484771-19-7
- 分子式: C26H46N4
- 分子量:414.67
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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CXCR4 19.8 nM (IC50) |
HIV-1 1.5 μM (IC50) |
化学情報
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CAS 番号 2484771-19-7
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性状 Solid
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分子量 414.67
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分子式 C26H46N4
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Color White to light yellow
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SMILES
C1(CNCCCNC2CCCCC2)=CC=C(CNCCCNC3CCCCC3)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外:
DMSO : 104 mg/mL (250.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Fang X, Meng Q, Zhang H, Liang B, Zhu S, Wang J, Zhang C, Huang LS, Zhang X, Schooley RT, An J, Xu Y, Huang Z. Design, synthesis, and biological characterization of a new class of symmetrical polyamine-based small molecule CXCR4 antagonists. Eur J Med Chem. 2020 Aug 15;200:112410. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4116 mL | 12.0578 mL | 24.1156 mL | 60.2889 mL |
| 5 mM | 0.4823 mL | 2.4116 mL | 4.8231 mL | 12.0578 mL | |
| 10 mM | 0.2412 mL | 1.2058 mL | 2.4116 mL | 6.0289 mL | |
| 15 mM | 0.1608 mL | 0.8039 mL | 1.6077 mL | 4.0193 mL | |
| 20 mM | 0.1206 mL | 0.6029 mL | 1.2058 mL | 3.0144 mL | |
| 25 mM | 0.0965 mL | 0.4823 mL | 0.9646 mL | 2.4116 mL | |
| 30 mM | 0.0804 mL | 0.4019 mL | 0.8039 mL | 2.0096 mL | |
| 40 mM | 0.0603 mL | 0.3014 mL | 0.6029 mL | 1.5072 mL | |
| 50 mM | 0.0482 mL | 0.2412 mL | 0.4823 mL | 1.2058 mL | |
| 60 mM | 0.0402 mL | 0.2010 mL | 0.4019 mL | 1.0048 mL | |
| 80 mM | 0.0301 mL | 0.1507 mL | 0.3014 mL | 0.7536 mL | |
| 100 mM | 0.0241 mL | 0.1206 mL | 0.2412 mL | 0.6029 mL |
HF50731 関連分類
HY-146413 関連分類
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