INY-05-040
Based on 1 publication(s) in Google Scholar
INY-05-040 is an AKT degrader that can selectively and quickly degrade all three AKT isoforms. INY-05-040 exhibits anti-cancer activity. INY-05-040 can inhibit downstream signaling and cell proliferation in 288 cancer cell lines. INY-05-040 can suppress AKT signaling and induces the stress mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase (JNK). INY-05-040 is effective for breast cancer lines with a low-baseline activation of stress MAPK pathway. INY-05-040 can be studied for anti-cancer research.
(Pink: Akt ligand (HY-130988); Blue: VHL ligand (HY-112078); Black: linker (HY-W009413)).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.54%
- CAS 番号: 2503018-29-7
- 分子式: C55H76ClN9O6S
- 分子量:1026.77
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 INY-05-040
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生物活性
製品説明
体外実験
INY-05-040 (10-1000 nM, 24 h) demonstrates AKT signaling suppression in T47D cells[1].
INY-05-040 (100 nM, 0-72 h) results in reduced levels of total ribosomal S6 protein and sustained AKT reduction and suppression of downstream signaling in T47D cells[1].
INY-05-040 (100 nM, 10 h) causes differential abundance of 1394 transcripts in T47D cell lines[1].
INY-05-040 (100nM, 8-120 h) induces sustained phosphorylation of the JNK target c-Jun at Ser73 and an increase in total c-Jun protein levels, which is a marker for JNK activation in BT-474 and T47D cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
INY-05-040 (30-40 mg/kg, i.p., single dose) results in a prolonged AKT inhibition in BT474 subcutaneous tumor xenograft mice model[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2503018-29-7
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性状 Solid
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分子量 1026.77
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分子式 C55H76ClN9O6S
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Color White to off-white
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SMILES
C[C@H]1C2=C(N3CCN(CC3)C([C@@H](C4=CC=C(C=C4)Cl)CNCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=O)N=CN=C2[C@@H](C1)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
体外:
DMSO : ≥ 100 mg/mL (97.39 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[2]. Chen, C., et al., (2024). Down-Regulation of AKT Proteins Slows the Growth of Mutant-KRAS Pancreatic Tumors. Cells, 13(12), 1061. [Content Brief]
[3]. Wu, Y., et al., (2025). Pharmacodynamics of Akt drugs revealed by a kinase-modulated bioluminescent indicator. Nature chemical biology, 21(8), 1194–1204. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9739 mL | 4.8696 mL | 9.7393 mL | 24.3482 mL |
| 5 mM | 0.1948 mL | 0.9739 mL | 1.9479 mL | 4.8696 mL | |
| 10 mM | 0.0974 mL | 0.4870 mL | 0.9739 mL | 2.4348 mL | |
| 15 mM | 0.0649 mL | 0.3246 mL | 0.6493 mL | 1.6232 mL | |
| 20 mM | 0.0487 mL | 0.2435 mL | 0.4870 mL | 1.2174 mL | |
| 25 mM | 0.0390 mL | 0.1948 mL | 0.3896 mL | 0.9739 mL | |
| 30 mM | 0.0325 mL | 0.1623 mL | 0.3246 mL | 0.8116 mL | |
| 40 mM | 0.0243 mL | 0.1217 mL | 0.2435 mL | 0.6087 mL | |
| 50 mM | 0.0195 mL | 0.0974 mL | 0.1948 mL | 0.4870 mL | |
| 60 mM | 0.0162 mL | 0.0812 mL | 0.1623 mL | 0.4058 mL | |
| 80 mM | 0.0122 mL | 0.0609 mL | 0.1217 mL | 0.3044 mL |
INY-05-040 関連分類
HY-160469 関連分類
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