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製品番号: HY-N6736

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K-252c

K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC₅₀ of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase.

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CAS 番号: 85753-43-1
分子式: C₂₀H₁₃N₃O
分子量:311.34

保管条件:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

K-252c 構造式

CAS 番号: 85753-43-1

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

IC50: 2.45 µM (PKC)^[1].

Beta-lactamase アイソフォーム固有の製品をすべて表示 :

PKC アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
B16	IC₅₀	4.8 μM Compound: 11	Antiproliferative activity against B16 mouse melanoma cells Antiproliferative activity against B16 mouse melanoma cells	[PMID: 8893841]
HCT-116	IC₅₀	1.72 μM Compound: 3 (K-252c)	In vitro antiproliferative activity against HCT116 ( human colon) cell line. In vitro antiproliferative activity against HCT116 ( human colon) cell line.	[PMID: 14552792]
HCT-116	IC₅₀	1.72 μM Compound: 9	Inhibition of human HCT(colon) carcinoma cell proliferation Inhibition of human HCT(colon) carcinoma cell proliferation	[PMID: 14552791]
HCT-116	IC₅₀	1.72 μM Compound: K252c	Cytotoxicity against human HCT116 cells Cytotoxicity against human HCT116 cells	[PMID: 27255178]
K562	IC₅₀	7.8 μM Compound: K252c	Cytotoxicity against human K562 cells Cytotoxicity against human K562 cells	[PMID: 27255178]
NCI-H460	IC₅₀	3.2 μM Compound: 3 (K-252c)	In vitro antiproliferative activity against NCI-460 (human lung) cell line. In vitro antiproliferative activity against NCI-460 (human lung) cell line.	[PMID: 14552792]
NCI-H460	IC₅₀	3.2 μM Compound: 9	Inhibition of human NCI-H460 (lung) carcinoma cell proliferation Inhibition of human NCI-H460 (lung) carcinoma cell proliferation	[PMID: 14552791]
P388	IC₅₀	4 μM Compound: 11	Antiproliferative activity against P388 Murine Leukemia cells Antiproliferative activity against P388 Murine Leukemia cells	[PMID: 8893841]
PANC-1	IC₅₀	1.8 μM Compound: 131	Inhibition of Gli1-mediated transcription expressed in human PANC1 cells Inhibition of Gli1-mediated transcription expressed in human PANC1 cells	[PMID: 19309080]
PANC-1	IC₅₀	2.7 μM Compound: 131	Inhibition of Gli2-mediated transcription expressed in human PANC1 cells Inhibition of Gli2-mediated transcription expressed in human PANC1 cells	[PMID: 19309080]
Sf21	IC₅₀	61 nM Compound: 23, K-252c	Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylation Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylation	[PMID: 19427203]

化学情報

CAS 番号 85753-43-1
性状 Solid
分子量 311.34
分子式 C₂₀H₁₃N₃O
Color White to off-white
SMILES

O=C1NCC2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)NC6=C3C=CC=C6
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
- Microorganisms
Nocardiopsis sp.
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Pereira, E.R., et al. Structure-activity relationships in a series of substituted indolocarbazoles: Topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties J. Med. Chem. 39(22), 4471-4477 (1996). [Content Brief]

[2]. Liu, R., et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z2039-2 Arch. Pharm. Res. 30(3), 270-274 (2007). [Content Brief]

[3]. Zimmermann, A., et al. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase Antiviral Res. 48(1), 49-60 (2000). [Content Brief]

[4]. McGovern, S.L., et al. Kinase inhibitors: Not just for kinases anymore Journal of Medicinal Chemistry 46, 1478-1483 (2003). [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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K-252c

Beta-lactamase アイソフォーム固有の製品をすべて表示

PKC アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

K-252c 関連分類

HY-N6736 関連分類