L-783277
L-783277 (Compound 4) is a MEK inhibitor (IC50 = 4 nM). L-783277 has potent inhibitory activity against a variety of kinases, including VEGFR2/3, FLT1/3/4, MEK1/2, KDR, and PDGFRα, but has low selectivity for the kinase community. L-783277 inhibits viability (IC50 = 22 mM) and cell proliferation (IC50 = 21 mM) of H295R cells. L-783277 could be used in research on cancers such as adrenocortical carcinoma.
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- CAS 番号: 791807-02-8
- 分子式: C19H24O7
- 分子量:364.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
0.01 μM
Compound: L783277
|
Antiproliferative activity against human MV4-11 cells after 72 hrs by luminescent cell viability assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by luminescent cell viability assay
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[PMID: 25456387] |
| THP-1 | IC50 |
1.18 μM
Compound: L783277
|
Antiproliferative activity against human THP1 cells after 72 hrs by luminescent cell viability assay
Antiproliferative activity against human THP1 cells after 72 hrs by luminescent cell viability assay
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[PMID: 25456387] |
化学情報
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CAS 番号 791807-02-8
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分子量 364.39
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分子式 C19H24O7
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SMILES
O=C(O[C@@H](C)C/C=C\1)C2=C(O)C=C(OC)C=C2CCC[C@H](O)[C@H](O)C1=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Kim Y, et al. Natural and Synthetic Lactones Possessing Antitumor Activities. Int J Mol Sci. 2021 Jan 21;22(3):1052. [Content Brief]
[2]. Lawnicka H, et al. Resorcylic acid lactone L-783,277 inhibits the growth of the human adrenal cancer cell line H295R in vitro. Int J Immunopathol Pharmacol. 2009 Oct-Dec;22(4):889-95. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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