LZ9
LZ9 is a ATP-competitive CDK1 and CDK2 inhibitor. LZ9 has the potential for the research of colorectal cancer (CRC).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 844441-29-8
- 分子式: C17H11F3N4O2
- 分子量:360.29
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
|
CDK1 |
cyclin B1/CDC2 |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A2058 | IC50 |
1.011 μM
Compound: DC-K2in2
|
Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 96 hrs by Celltiter-Glo luminescent assay
Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 96 hrs by Celltiter-Glo luminescent assay
|
[PMID: 33611192] |
| A-375 | IC50 |
13.38 μM
Compound: 1
|
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
|
[PMID: 31991336] |
| HCT-116 | IC50 |
1.4 μM
Compound: 23
|
Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by alamar blue assay
Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by alamar blue assay
|
[PMID: 18656911] |
| HCT-116 | IC50 |
1.4 μM
Compound: 8d
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Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar blue assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar blue assay
|
[PMID: 26115571] |
| HCT-116 | IC50 |
1.96 μM
Compound: 1
|
Antiproliferative activity against human HCT116 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HCT116 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 31991336] |
| HeLa | IC50 |
8.23 μM
Compound: 1
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Antiproliferative activity against human Hela cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human Hela cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 31991336] |
| NCI-H460 | IC50 |
9.46 μM
Compound: 1
|
Antiproliferative activity against human H460 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human H460 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
|
[PMID: 31991336] |
| SMMC-7721 | IC50 |
23.21 μM
Compound: 1
|
Antiproliferative activity against human SMMC7721 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human SMMC7721 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
|
[PMID: 31991336] |
化学情報
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CAS 番号 844441-29-8
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分子量 360.29
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分子式 C17H11F3N4O2
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SMILES
O=C(C1=NNC=C1NC(C2=C(F)C=CC=C2F)=O)NC3=CC=C(C=C3)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Lu Z, et al. Computational design of CDK1 inhibitors with enhanced target affinity and drug-likeness using deep-learning framework. Heliyon. 2024 Nov 14;10(22):e40345. [Content Brief]
[2]. Ogbodo UC, et al. Computational identification of potential inhibitors targeting cdk1 in colorectal cancer. Front Chem. 2023 Nov 30;11:1264808. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LZ9 関連分類
HY-170306 関連分類
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