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製品番号: HY-P992517

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mDF6002

mDF6002 is a IL-12R-Fc fusion protein. mDF6002 induces sustained IFNγ production. mDF6002 exerts tumor-suppressive effects in mouse models of colon cancer and melanoma. mDF6002 can be used for research on solid tumors such as colon cancer and melanoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

mDF6002 構造式

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
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生物活性

製品説明

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体外実験

Cytokines & Chemokines

mDF6006 (0.006-6250 pM; 60 h) potently induces IFN-γ production in naive Balb/c mouse splenocytes with an EC₅₀ of 2.07 pM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	AUC_0-t	C_max	T_max	AUC
Mice^[1]	10 μg/mL	i.v.	29.85 h	5,637 ng·h/mL	258 ng/mL	0.19 h	/
Mice^[1]	10 μg/mL	s.c.	/	/	/	/	6.33 ng·h/mL

体内実験

Anti-cancerAdaptive ImmunityCytokines &Chemokines

Anti-cancer

Adaptive Immunity

mDF6006 (1 μg; s.c.; once weekly; 7 weeks) achieves 100% complete tumor regression in advanced large CT26 colon carcinoma-bearing BALB/cJ mice and induces protective T cell memory in 90% of treated mice^[1].

Anti-cancer

Cytokines &

Chemokines

mDF6006 (0.5 μg; i.p.; once weekly) induces partial responses in 90% of B16F10 melanoma-bearing C57BL/6J mice and drives sustained pharmacodynamic responses in both tumor and serum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/cJ mice (female, 7-9 weeks old, subcutaneous inoculation with CT26 cells, advanced large tumors averaging 815 mm³)^[1]
Dosage:

1 μg (equimolar to 1 μg rmIL-12)
Administration:

s.c.; once weekly; 7 weeks
Result:

Induced complete tumor regression in all 10 treated mice.
Was well tolerated with no body weight loss.
Enabled 9/10 complete responders to reject tumor rechallenge and remain tumor-free, while age-matched naive controls developed progressive tumors.

Animal Model:

C57BL/6J mice (female, 7-9 weeks old, subcutaneous inoculation with B16F10 cells)^[1]
Dosage:

0.5 μg (equimolar to 0.5 μg rmIL-12)
Administration:

i.p.; once weekly
Result:

Induced partial responses in 9/10 treated mice.
Significantly improved survival compared to rmIL-12.
Significantly elevated and protracted levels of IFNγ, CXCL9, CXCL10, CCL5, and TNF-α were detected in both tumor lysates and serum at 72 hours post-dose.

化学情報

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Gutierrez E, et al. An optimized IL-12-Fc expands its therapeutic window, achieving strong activity against mouse tumors at tolerable drug doses. Med. 2023 May 12;4(5):326-340.e5. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
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mDF6002

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

PBS Buffer (1×)

CXCR アイソフォーム固有の製品をすべて表示

TNF Receptor アイソフォーム固有の製品をすべて表示