ML 10302
Based on 1 Customer Validation
ML 10302 is a potent agonist 5-HT4 receptor with Ki of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.95%
- CAS 番号: 148868-55-7
- 分子式: C15H21ClN2O3
- 分子量:312.79
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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5-HT Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C6 | EC50 |
51 nM
Compound: ML-10302
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Agonist activity at human 5HT4 isoform E receptor expressed in rat C6 cells assessed as cAMP accumulation by radio-immunoassay relative to 5HT
Agonist activity at human 5HT4 isoform E receptor expressed in rat C6 cells assessed as cAMP accumulation by radio-immunoassay relative to 5HT
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[PMID: 19334715] |
| CHO | EC50 |
2.5 nM
Compound: ML-10302
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Agonist activity at human 5HT4e receptor expressed in CHO cells assessed as cAMP level after 4 hrs by luciferase reporter gene assay
Agonist activity at human 5HT4e receptor expressed in CHO cells assessed as cAMP level after 4 hrs by luciferase reporter gene assay
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[PMID: 26363507] |
化学情報
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CAS 番号 148868-55-7
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性状 Solid
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分子量 312.79
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分子式 C15H21ClN2O3
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Color White to off-white
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SMILES
O=C(OCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (399.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Cachard-Chastel M, et al. 5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol. 2007;150(7):883-892. [Content Brief]
[2]. Yang D, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997;40(4):608-621. [Content Brief]
[3]. De Ponti F, et al. Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon. Neurogastroenterol Motil. 2001;13(6):543-553. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1970 mL | 15.9852 mL | 31.9703 mL | 79.9258 mL |
| 5 mM | 0.6394 mL | 3.1970 mL | 6.3941 mL | 15.9852 mL | |
| 10 mM | 0.3197 mL | 1.5985 mL | 3.1970 mL | 7.9926 mL | |
| 15 mM | 0.2131 mL | 1.0657 mL | 2.1314 mL | 5.3284 mL | |
| 20 mM | 0.1599 mL | 0.7993 mL | 1.5985 mL | 3.9963 mL | |
| 25 mM | 0.1279 mL | 0.6394 mL | 1.2788 mL | 3.1970 mL | |
| 30 mM | 0.1066 mL | 0.5328 mL | 1.0657 mL | 2.6642 mL | |
| 40 mM | 0.0799 mL | 0.3996 mL | 0.7993 mL | 1.9981 mL | |
| 50 mM | 0.0639 mL | 0.3197 mL | 0.6394 mL | 1.5985 mL | |
| 60 mM | 0.0533 mL | 0.2664 mL | 0.5328 mL | 1.3321 mL | |
| 80 mM | 0.0400 mL | 0.1998 mL | 0.3996 mL | 0.9991 mL | |
| 100 mM | 0.0320 mL | 0.1599 mL | 0.3197 mL | 0.7993 mL |
ML 10302 関連分類
HY-14441 関連分類
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