Nerolidol-d4
Nerolidol-d4 is deuterated labeled Nerolidol (HY-N1944). Nerolidol has multiple natural membrane activities, possesses anti-cancer, anti-inflammatory, antibacterial and anti-insect activity. Nerolidol Suppresses parasitic activity, suppresses bloodsucking diseases, bloodworm diseases, and other diseases. Nerolidol can protect the cells from lipid and protein properties, damage to DNA, and protect the cells from damage.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C15H22D4O
- 分子量:226.39
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
Nerolidol exhibits potent antioxidant properties in counterbalancing the effect of ROS by protecting the cells against oxidative damage to lipids, proteins and DNA[3].
Nerolidol exhibits potent antimicrobial activity against Staphylococcus aureus FDA 209P, 14 strains of methicillin-susceptible S. aureus (MSSA) and 20 strains of methicillin-resistant S. aureus (MRSA) with MIC values ranging from 512 to over 1024 μg/mL[3].
Nerolidol exhibits anti-biofilm activity against a number of pathogens[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Nerolidol (25-75 mg/kg; ip; single dose) shows neuroprotective effects in mice hippocampus against oxidative stress in neuronal cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
-
非標識Cas 7212-44-4
-
分子量 226.39
-
分子式 C15H22D4O
-
SMILES
C=CC(O)(C)C([2H])([2H])C([2H])([2H])/C=C(C)/CC/C=C(C)/C
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Nogueira Neto JD, et al. Antioxidant effects of nerolidol in mice hippocampus after open field test. Neurochem Res. 2013 Sep;38(9):1861-70. [Content Brief]
[3]. Chan WK, et al. Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities. Molecules. 2016 Apr 28;21(5):529. [Content Brief]
[4]. Nerolidol, et al. In vitro antileishmanial and cytotoxic activities of nerolidol are associated with changes in plasma membrane dynamics. Biochim Biophys Acta Biomembr. 2019 Jun 1;1861(6):1049-1056. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Nerolidol-d4 関連分類
HY-N1944S 関連分類
Powered by Bioz