NOTA-NHS ester
Based on 1 publication(s) in Google Scholar
NOTA-NHS ester is a chelating agent. NOTA-NHS ester can be coupled with T140 (HY-P4810) to produce NOTA-T140. NOTA-T140 can be radiolabeled with Al[18F]. The uptake of Al[18F]NOTA-T140 in tumors is correlated with the expression level of CXCR4. Al[18F]NOTA-T140 can be used in tumor PET imaging studies. NOTA-NHS ester can be used for fluorescent labeling.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 90.0%
- CAS 番号: 1338231-09-6
- 分子式: C16H24N4O8
- 分子量:400.38
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 NOTA-NHS ester
MoreRadionuclide-Drug Conjugates (RDCs) アイソフォーム固有の製品をすべて表示
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生物活性
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RDC Bifunctional Chelator |
CXCR4 |
NOTA-T140, generated by coupling NOTA-NHS ester with T140 (HY-P4810), can be radiolabeled with Al[18F]. The uptake of Al[18F]-labeled NOTA-T140 in tumors is correlated with the expression level of CXCR4 and can be used for tumor PET imaging studies[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1338231-09-6
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性状 Solid
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分子量 400.38
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分子式 C16H24N4O8
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Color White to light yellow
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SMILES
O=C(O)CN1CCN(CC(ON2C(CCC2=O)=O)=O)CCN(CC(O)=O)CC1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Eur J Med Chem
Click chemistry-driven modular radionuclide labeling of HER2 nanobody: An integrated platform for diagnosis and treatment of precision oncology. [Abstract]2026 Jun 26:317:119104. PMID: 42419170
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (249.76 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Lang L, et al. Stability analysis of glutamic acid linked peptides coupled to NOTA through different chemical linkages. Mol Pharm. 2014 Nov 3;11(11):3867-74. [Content Brief]
[2]. Chen CJ, et al. 68Ga-labelled NOTA-RGD-GE11 peptide for dual integrin and EGFR-targeted tumour imaging. Nucl Med Biol. 2019 Jan-Feb;68-69:22-30. [Content Brief]
[3]. Yan X, et al. Al[18F]NOTA-T140 Peptide for Noninvasive Visualization of CXCR4 Expression. Mol Imaging Biol. 2016 Feb;18(1):135-42. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4976 mL | 12.4881 mL | 24.9763 mL | 62.4407 mL |
| 5 mM | 0.4995 mL | 2.4976 mL | 4.9953 mL | 12.4881 mL | |
| 10 mM | 0.2498 mL | 1.2488 mL | 2.4976 mL | 6.2441 mL | |
| 15 mM | 0.1665 mL | 0.8325 mL | 1.6651 mL | 4.1627 mL | |
| 20 mM | 0.1249 mL | 0.6244 mL | 1.2488 mL | 3.1220 mL | |
| 25 mM | 0.0999 mL | 0.4995 mL | 0.9991 mL | 2.4976 mL | |
| 30 mM | 0.0833 mL | 0.4163 mL | 0.8325 mL | 2.0814 mL | |
| 40 mM | 0.0624 mL | 0.3122 mL | 0.6244 mL | 1.5610 mL | |
| 50 mM | 0.0500 mL | 0.2498 mL | 0.4995 mL | 1.2488 mL | |
| 60 mM | 0.0416 mL | 0.2081 mL | 0.4163 mL | 1.0407 mL | |
| 80 mM | 0.0312 mL | 0.1561 mL | 0.3122 mL | 0.7805 mL | |
| 100 mM | 0.0250 mL | 0.1249 mL | 0.2498 mL | 0.6244 mL |
NOTA-NHS ester 関連分類
HY-W087028 関連分類
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