Solavetivone
Solavetivone is a Sesquiterpenoid phytoalexin and Antifungal agent. Solavetivone is isolated from stress-challenged potato plants. Solavetivone is hydroxylated by sesquiterpenoid phytoalexin hydroxylase (SPH/CYP76A2L). Solavetivone helps solanaceous plants defend against pathogens, damages plant cells after pathogen threat, and inhibits mycelial growth of Rhizoctonia solani. Solavetivone is applicable to studies related to Rhizoctonia solani infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 54878-25-0
- 分子式: C15H22O
- 分子量:218.33
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
CYP76A2L |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| OVCAR-3 | IC50 |
0.1 mM
Compound: 1, Solavetivone
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Cytotoxicity against human OVCAR-3 cells
Cytotoxicity against human OVCAR-3 cells
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[PMID: 11575964] |
体外実験
Solavetivone (3.2-16.1 μg/mL; 48 h) inhibits in vitro mycelial growth of Rhizoctonia solani in a concentration-dependent manner, with 27.6% inhibition observed at 16.1 μg/mL after 48 h incubation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 54878-25-0
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分子量 218.33
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分子式 C15H22O
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SMILES
C[C@H]1[C@@]2(C(C)=CC(C1)=O)C[C@@H](CC2)C(C)=C
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Filamentous Fungal Mold Culture and Sporulation
Filamentous fungal mold culture and sporulation assays grow hyphae under defined nutritional and environmental conditions until asexual spores, commonly conidia, are produced; the main readouts are colony growth, sporulation onset, conidial yield, conidial morphology, viability, and, when relevant, downstream infectivity or stress phenotype.
純度とドキュメンテーション
参考文献
[1]. Camagna M, et al. Detoxification of the solanaceous phytoalexins rishitin, lubimin, oxylubimin and solavetivone via a cytochrome P450 oxygenase. Plant Signal Behav. 2020;15(2):1707348. [Content Brief]
[3]. Yao MK, et al. Effect of mycorrhization on the accumulation of rishitin and solavetivone in potato plantlets challenged with Rhizoctonia solani. Mycorrhiza. 2003;13(6):333-336. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Solavetivone 関連分類
HY-N12475 関連分類
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Keywords
- Solavetivone
- 54878-25-0
- Fungal
- Cytochrome P450
- sesquiterpenoid phytoalexins hydroxylase
- Glomus etunicatum
- Hyoscyamus muticus
- calcium-alginate immobilized Hyoscyamus muticus cells
- Solanum plants
- Rhizoctonia solani
- Nicotiana benthamiana
- SPH/CYP76A2L
- Solanum tuberosum cv. Goldrush
- potato roots
- Inhibitor
- inhibitor
- inhibit