TG 100713
Based on 2 publication(s) in Google Scholar
TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.21%
- CAS 番号: 925705-73-3
- 分子式: C12H10N6O
- 分子量:254.25
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 TG 100713
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生物活性
製品説明
IC50 & Target
[1]|
PI3Kδ 24 nM (IC50) |
PI3Kγ 50 nM (IC50) |
PI3Kα 165 nM (IC50) |
PI3Kβ 215 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.49 μM
Compound: TG100713
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Anticancer activity against human A549 cells by MTT assay
Anticancer activity against human A549 cells by MTT assay
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10.1039/C3MD00301A |
| HeLa | IC50 |
0.15 μM
Compound: TG100713
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Anticancer activity against human HeLa cells by MTT assay
Anticancer activity against human HeLa cells by MTT assay
|
10.1039/C3MD00301A |
| HepG2 | IC50 |
0.82 μM
Compound: TG100713
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Anticancer activity against human HepG2 cells by MTT assay
Anticancer activity against human HepG2 cells by MTT assay
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10.1039/C3MD00301A |
| MCF7 | IC50 |
1.03 μM
Compound: TG100713
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Anticancer activity against human MCF7 cells by MTT assay
Anticancer activity against human MCF7 cells by MTT assay
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10.1039/C3MD00301A |
体外実験
TG100713 (10 μM; 48 or 72 h) strongly inhibits endothelial cell (EC) proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
化学情報
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CAS 番号 925705-73-3
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性状 Solid
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分子量 254.25
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分子式 C12H10N6O
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Color Light yellow to khaki
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SMILES
OC1=CC=CC(C2=NC3=C(N)N=C(N)N=C3N=C2)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Molecules
In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against Leishmania donovani and Trypanosoma brucei. [Abstract]2020 Apr 23;25(8):1980. PMID: 32340370 -
Sci Rep
QSAR analysis on a large and diverse set of potent phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using MLR and ANN methods. [Abstract]2022 Apr 12;12(1):6090. PMID: 35414065
溶剤 & 溶解度
体外:
DMSO : 6.41 mg/mL (25.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9331 mL | 19.6657 mL | 39.3314 mL | 98.3284 mL |
| 5 mM | 0.7866 mL | 3.9331 mL | 7.8663 mL | 19.6657 mL | |
| 10 mM | 0.3933 mL | 1.9666 mL | 3.9331 mL | 9.8328 mL | |
| 15 mM | 0.2622 mL | 1.3110 mL | 2.6221 mL | 6.5552 mL | |
| 20 mM | 0.1967 mL | 0.9833 mL | 1.9666 mL | 4.9164 mL | |
| 25 mM | 0.1573 mL | 0.7866 mL | 1.5733 mL | 3.9331 mL |
TG 100713 関連分類
HY-13514 関連分類
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