UNC8153
Based on 1 Customer Validation
UNC8153 is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 reduces the cellular levels of both NSD2 protein (DC50 in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark. UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.61%
- CAS 番号: 2929304-60-7
- 分子式: C33H37N5O5
- 分子量:583.68
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
UNC8153 (0-20 μM, 96 h) exhibits anti-adhesion effect in KMS11 cell, and exhibits mild cytotoxicity against MM1S cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MM1S
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Concentration:0-50 μM
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Incubation Time:96 h
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Result:Inhibited the cell proliferation.
化学情報
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CAS 番号 2929304-60-7
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性状 Solid
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分子量 583.68
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分子式 C33H37N5O5
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Color White to off-white
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SMILES
O=C(C1=CC=C2NC(COC2=C1)=O)N(CC3=CC=C(C(NC4=CC=C(C(NCCCCCCN)=O)C=C4)=O)C=C3)C5CC5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (171.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7133 mL | 8.5663 mL | 17.1327 mL | 42.8317 mL |
| 5 mM | 0.3427 mL | 1.7133 mL | 3.4265 mL | 8.5663 mL | |
| 10 mM | 0.1713 mL | 0.8566 mL | 1.7133 mL | 4.2832 mL | |
| 15 mM | 0.1142 mL | 0.5711 mL | 1.1422 mL | 2.8554 mL | |
| 20 mM | 0.0857 mL | 0.4283 mL | 0.8566 mL | 2.1416 mL | |
| 25 mM | 0.0685 mL | 0.3427 mL | 0.6853 mL | 1.7133 mL | |
| 30 mM | 0.0571 mL | 0.2855 mL | 0.5711 mL | 1.4277 mL | |
| 40 mM | 0.0428 mL | 0.2142 mL | 0.4283 mL | 1.0708 mL | |
| 50 mM | 0.0343 mL | 0.1713 mL | 0.3427 mL | 0.8566 mL | |
| 60 mM | 0.0286 mL | 0.1428 mL | 0.2855 mL | 0.7139 mL | |
| 80 mM | 0.0214 mL | 0.1071 mL | 0.2142 mL | 0.5354 mL | |
| 100 mM | 0.0171 mL | 0.0857 mL | 0.1713 mL | 0.4283 mL |
UNC8153 関連分類
HY-157251A 関連分類
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