UNC9750
UNC9750 is an inositol phosphate multikinase (IPMK) inhibitor with IC50 values of 31.6 and 374 nM for IPMK and IP6K2, respectively.. UNC9750 inhibits cellular accumulation of InsP5, the direct product of IPMK kinase activity, while having no effect on either InsP6 or InsP7 levels. UNC9750 has ≥ 75% inhibition of four kinases (DAPK1, DYRK1B, PDGFR, and KDR). UNC9750 can be used for the study of glioblastoma.
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- CAS 番号: 2967648-29-7
- 分子式: C23H24N6O
- 分子量:400.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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DYRK1B |
DAPK1 |
PDGFR |
PDGFR2 |
UNC9750 (Compound 14) (0-10 μM, 48-72 h) decreases human glioblastoma cell U251-MG growth and selectively reduces cellular InsP5 abundance but does not decrease InsP6 or InsP7 levels after 72 h[1].
UNC9750 (1 μM) has ≥ 75% inhibition of four kinases (DAPK1, DYRK1B, PDGFR, and KDR[1].
UNC9750 (10-50 μM, 24 h) can significantly and concentration-dependently upregulate the expression of SF-1 target gene CYP11A1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | T1/2 | Cmax | AUClast | Vss | CL |
|---|---|---|---|---|---|---|---|
| Mice[1] | 2.75 mg/kg | i.v. | 1.95 h | 28.3 μM | 4.6 μM·h | 0.39 L/kg | 22.8 mL/min/kg |
化学情報
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CAS 番号 2967648-29-7
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分子量 400.48
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分子式 C23H24N6O
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SMILES
C1(C2=NN=NN2)=CC3=C(ON=C3C=C1)C4=CC(C5CCN(CC5)C6CCC6)=CC=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
UNC9750 関連分類
HY-175477 関連分類
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