製品番号: HY-153886

Wu-5

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.01%
CAS 番号: 2630378-05-9
分子式: C₁₅H₁₃NO₇S
分子量:351.33

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Wu-5 構造式

CAS 番号: 2630378-05-9

容量

価格（税別）

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数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis^[1].

IC₅₀ & Target

USP10

AMPK アイソフォーム固有の製品をすべて表示 :

Deubiquitinase アイソフォーム固有の製品をすべて表示 :

体外実験

Wu-5 (10 μM; 24, 48, 72 h) selectively induces the death of FLT3-ITD-positive AML cells^[1].
Wu-5 (1, 2.5, 5 μM; 24, 48 h) induces apoptosis of FLT3-ITD-positive AML cells in a concentration and time-dependent manner^[1].
Wu-5 (5 μM; 24 h) induces FLT3-ITD degradation by the proteasome pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

U937, HL60, MV4-11, Molm13, and MV4-11-R cells
Concentration:

10 μM
Incubation Time:

24, 48, 72 h
Result:

Significantly inhibited the growth of the FLT3-ITD-positive cells (MV4-11, MV4-11-R and Molm13 cells), but had no or little effect on the proliferation of the FLT3-ITD negative cells (U937 and HL60 cells).

Apoptosis Analysis^[1]

Cell Line:

MV4-11, and Molm13 cells
Concentration:

1, 2.5, 5 μM
Incubation Time:

24, 48 h
Result:

Induced the apoptosis of MV4-11 and Molm13 in a concentration and time-dependent manner.

Western Blot Analysis^[1]

Cell Line:

MV4-11, MV4-11-R, and Molm13 cells
Concentration:

5 μM
Incubation Time:

24 h
Result:

Induced FLT3-ITD degradation.

化学情報

CAS 番号 2630378-05-9
性状 Solid
分子量 351.33
分子式 C₁₅H₁₃NO₇S
Color Off-white to light yellow
SMILES

O=C(C1=CC=C(C=C1)OC2=C([N+]([O-])=O)C=C(C(OCC)=O)S2)OC
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Microbiol Spectr

The TgAMPK-TgPFKII axis essentially regulates protein lactylation in the zoonotic parasite Toxoplasma gondii. [Abstract]

2025 Mar 4;13(3):e0204424. PMID: 39918324

溶剤 & 溶解度

体外:

DMSO : 25 mg/mL (71.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8463 mL

14.2316 mL

28.4633 mL

5 mM

0.5693 mL

2.8463 mL

5.6927 mL

10 mM

0.2846 mL

1.4232 mL

2.8463 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Miao Yu, et al. Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways. Acta Pharmacol Sin. 2021 Apr;42(4):604-612. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8463 mL	14.2316 mL	28.4633 mL	71.1582 mL
	5 mM	0.5693 mL	2.8463 mL	5.6927 mL	14.2316 mL
	10 mM	0.2846 mL	1.4232 mL	2.8463 mL	7.1158 mL
	15 mM	0.1898 mL	0.9488 mL	1.8976 mL	4.7439 mL
	20 mM	0.1423 mL	0.7116 mL	1.4232 mL	3.5579 mL
	25 mM	0.1139 mL	0.5693 mL	1.1385 mL	2.8463 mL
	30 mM	0.0949 mL	0.4744 mL	0.9488 mL	2.3719 mL
	40 mM	0.0712 mL	0.3558 mL	0.7116 mL	1.7790 mL
	50 mM	0.0569 mL	0.2846 mL	0.5693 mL	1.4232 mL
	60 mM	0.0474 mL	0.2372 mL	0.4744 mL	1.1860 mL

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Wu-5

1 Cited Publications

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Wu-5

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Highly Selective Inhibitors Library

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Anti-Brain Cancer Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Kinase Inhibitor Library

PI3K/Akt/mTOR Compound Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

MedChemExpress（MCE）の使用を引用している文献 Wu-5

AMPK アイソフォーム固有の製品をすべて表示

Deubiquitinase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Wu-5 関連分類

HY-153886 関連分類