Diphenylmethane
Based on 1 Customer Validation
Diphenylmethane (Benzylphenyl) is an Efflux Pump inhibitor. Diphenylmethane can be isolated from Gracilaria sp. Diphenylmethane can be prepared via the Friedel-Crafts reaction. Diphenylmethane interferes with AcrB-mediated efflux of antibiotics and dyes. Diphenylmethane shows no antibacterial activity against reagent-resistant Escherichia coli. Diphenylmethane does not increase the membrane permeability of Escherichia coli. Diphenylmethane can enhance the activity of antibiotics against reagent-resistant Escherichia coli. Diphenylmethane can be used to synthesize selective BVDV inhibitors.
For research use only. We do not sell to patients.
- Purity : 99.99%
- CAS No.: 101-81-5
- Formula: C13H12
- Molecular Weight:168.24
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
>250 μg/mL
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Cytotoxicity against human hepatic HepG2 cells assessed as viability reduction after 24 hrs incubation by trypan blue exclusion assay with IC50 >250 μg/mL.
Cytotoxicity against human hepatic HepG2 cells assessed as viability reduction after 24 hrs incubation by trypan blue exclusion assay with IC50 >250 μg/mL.
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34827316 |
In Vitro
Diphenylmethane (125-250 µg/mL; 18 h) combined with Erythromycin yields the lowest 18-h cell count (5.2 Log CFU/mL) in E. coli Kam3-AcrB, while alone at 125-250 µg/mL it does not inhibit growth[4].
Diphenylmethane (7.8-250 µg/mL) increases H33342 accumulation at 250 and 125 µg/mL and EtBr accumulation at 15.6 and 7.8 µg/mL in E. coli Kam3-AcrB[4].
Diphenylmethane (7.8-250 µg/mL) slows H33342 efflux at 250 and 125 µg/mL and EtBr efflux at 15.6 and 7.8 µg/mL in E. coli Kam3-AcrB[4].
Diphenylmethane (20 min) limits extracellular Erythromycin accumulation to 31.87 µg/mL in energized E. coli Kam3-AcrB[4].
Diphenylmethane (125-1000 µg/mL; 15 min) does not increase membrane permeability in E. coli Kam3-AcrB[4].
Diphenylmethane (125 µg/mL; 2 h) does not significantly alter Erythromycin or Clarithromycin PAE in E. coli Kam3-AcrB, with combined PAE values of 0.30 and 0.27 h[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human hepatic HepG2 cells
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Concentration:15.6, 31.3, 62.5, 125, and 250 µg/mL
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Incubation Time:24 h
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Result:Cell viability at 15.6 µg/mL was 95.6%; viability gradually decreased as concentration increased, with an IC50 >250 µg/mL in HepG2 cells.
Chemical Information
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CAS No. 101-81-5
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Appearance <24.5°C Solid,>24.5°C Liquid
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Molecular Weight 168.24
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Formula C13H12
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Color Colorless to off-white
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SMILES
C1(CC2=CC=CC=C2)=CC=CC=C1
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Synonyms
Benzylphenyl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 200 mg/mL (1188.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (276 KB)
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SDS (459 KB)
- English - EN (459 KB)
- Français - FR (459 KB)
- Deutsch - DE (459 KB)
- Norwegian - NO (459 KB)
- Español - ES (459 KB)
- Swedish - SV (459 KB)
- Italian - IT (459 KB)
- Korean - KR (459 KB)
- Portuguese - PT (459 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.9439 mL | 29.7194 mL | 59.4389 mL | 148.5972 mL |
| 5 mM | 1.1888 mL | 5.9439 mL | 11.8878 mL | 29.7194 mL | |
| 10 mM | 0.5944 mL | 2.9719 mL | 5.9439 mL | 14.8597 mL | |
| 15 mM | 0.3963 mL | 1.9813 mL | 3.9626 mL | 9.9065 mL | |
| 20 mM | 0.2972 mL | 1.4860 mL | 2.9719 mL | 7.4299 mL | |
| 25 mM | 0.2378 mL | 1.1888 mL | 2.3776 mL | 5.9439 mL | |
| 30 mM | 0.1981 mL | 0.9906 mL | 1.9813 mL | 4.9532 mL | |
| 40 mM | 0.1486 mL | 0.7430 mL | 1.4860 mL | 3.7149 mL | |
| 50 mM | 0.1189 mL | 0.5944 mL | 1.1888 mL | 2.9719 mL | |
| 60 mM | 0.0991 mL | 0.4953 mL | 0.9906 mL | 2.4766 mL | |
| 80 mM | 0.0743 mL | 0.3715 mL | 0.7430 mL | 1.8575 mL | |
| 100 mM | 0.0594 mL | 0.2972 mL | 0.5944 mL | 1.4860 mL |
Diphenylmethane Related Classifications
HY-W008814 Related Classifications
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