A20FMDV2
Based on 1 Customer Validation
A20FMDV2 is a highly selective αvβ6 integrin inhibitor with human IC50 values of 3 nM and binds with at least 1000-fold selectivity over other RGD-binding integrins. A20FMDV2 binds to the integrin’s RGD-binding site, induces rapid integrin internalization, and delays post-internalization integrin recycling to the cell surface. A20FMDV2 can be used for the research of pancreatic cancer, breast cancer, colorectal cancer, ovarian cancer, oral squamous cell carcinoma.
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- Purity: 99.80%
- CAS No.: 932699-03-1
- 화학식: C93H163N31O28
- 분자량:2163.48
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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αvβ6 3 nM (IC50) |
A20FMDV2 (0.01-6 nM; 1-24 h) binds to purified human αvβ6 integrin with high affinity (KD = 0.22 nM), fast association kinetics, partial reversibility by unlabelled A20FMDV2, and complete selectivity over other tested RGD integrins[1].
A20FMDV2 (1 μM; 0-48 h) induces rapid, concentration-dependent internalization of αvβ6 in NHBE cells (EC50 = 0.098 nmol/l, T1/2 = 1.5 min), followed by moderately slow recycling of the integrin to the cell surface[1].
A20FMDV2 (10 pM-100 μM; 1 h) potently and selectively inhibits αᵥβ6 ligand binding with an IC50 of 3 nmol/L, showing >1,000-fold higher specificity for αᵥβ6 than for αᵥβ3, αᵥβ5, and α5β1[2].
A20FMDV2 (1 nM-100 nM; 30 minute) binds specifically to αvβ6-expressing DX3puroβ6 cells at concentrations as low as 1 nmol/L, with no detectable binding to αvβ6-negative DX3puro cells even at 100 nmol/L[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 932699-03-1
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Appearance Solid
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분자량 2163.48
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화학식 C93H163N31O28
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Color White to off-white
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Sequence
Asn-Ala-Val-Pro-Asn-Leu-Arg-Gly-Asp-Leu-Gln-Val-Leu-Ala-Gln-Lys-Val-Ala-Arg-Thr
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Sequence Shortening
NAVPNLRGDLQVLAQKVART
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
H2O : ≥ 100 mg/mL (46.22 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Slack RJ, et al. Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2. Pharmacology. 2016;97(3-4):114-125. [Content Brief]
[2]. Hausner SH, et al. Use of a peptide derived from foot-and-mouth disease virus for the noninvasive imaging of human cancer: generation and evaluation of 4-[18F]fluorobenzoyl A20FMDV2 for in vivo imaging of integrin alphavbeta6 expression with positron emission tomography. Cancer Res. 2007 Aug 15;67(16):7833-40. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.4622 mL | 2.3111 mL | 4.6222 mL | 11.5555 mL |
| 5 mM | 0.0924 mL | 0.4622 mL | 0.9244 mL | 2.3111 mL | |
| 10 mM | 0.0462 mL | 0.2311 mL | 0.4622 mL | 1.1555 mL | |
| 15 mM | 0.0308 mL | 0.1541 mL | 0.3081 mL | 0.7704 mL | |
| 20 mM | 0.0231 mL | 0.1156 mL | 0.2311 mL | 0.5778 mL | |
| 25 mM | 0.0185 mL | 0.0924 mL | 0.1849 mL | 0.4622 mL | |
| 30 mM | 0.0154 mL | 0.0770 mL | 0.1541 mL | 0.3852 mL | |
| 40 mM | 0.0116 mL | 0.0578 mL | 0.1156 mL | 0.2889 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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