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Cat. No.: HY-WAA0304

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Agmatine

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

Agmatine is an orally active analgesic that can cross the blood-brain barrier. Agmatine targets the 5-HT_2A receptor, 5-HT₃ receptor, α₂-adrenergic receptor, and I1 imidazoline receptor. Agmatine produces dose-dependent analgesic effects in various pain models. Agmatine can be used in research related to visceral pain, neuropathic pain, and inflammatory pain.

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CAS No.: 306-60-5
화학식: C₅H₁₄N₄
분자량:130.19

보관:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Agmatine Chemical Structure

CAS No.: 306-60-5

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (1)
순도&문서
References
Calculators
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

5-HT_2A Receptor

5-HT₃ Receptor

α2-adrenergic receptor

All 5-HT Receptor Isoforms :

All Adrenergic Receptor Isoforms :

In Vivo

Agmatine (1-30 mg/kg; i.p.; 30 min pre-acetic acid, 0.5-6 hours pre-acetic acid; 10-300 mg/kg; p.o.; 60 min pre-acetic acid) produces dose-dependent, long-lasting antinociception against acetic acid-induced visceral pain in Mus musculus, with 26-fold greater potency via i.p. (ID₅₀ 5.6 mg/kg) than oral (ID₅₀ 147.3 mg/kg) administration, acting through nitrergic, opioid, α₂-adrenoceptor, imidazoline I₁, and serotonergic (5-HT_2A, 5-HT₃) pathways^[2].
Agmatine (10-100 mg/kg; i.p.; 30 min pre-glutamate) dose-dependently inhibits glutamate-induced paw nociception in mice with an ID₅₀ of 19.5 mg/kg (i.p.)^[2].
Agmatine (3-100 mg/kg; i.p.; 30 min pre-capsaicin) dose-dependently inhibits Capsaicin (HY-10448)-induced paw nociception in mice with an ID₅₀ of 43.7 mg/kg (i.p.)^[2].
Agmatine (1-100 mg/kg; i.p.; 30 min pre-formalin; 10 mg/kg; i.p.; 10 min pre-formalin; 10 mg/kg; i.p.; 5 min post-formalin) dose-dependently inhibits both neurogenic and inflammatory phases of formalin-induced paw nociception in mice, with greater potency against the inflammatory phase (ID₅₀ 5.6 mg/kg i.p.) than the neurogenic phase (ID₅₀ 13.7 mg/kg i.p.)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss mice (both sexes, 25-35 g)^[2]
Dosage:

1-30 mg/kg (i.p.); 10-300 mg/kg (p.o.)
Administration:

i.p. (30 min pre-acetic acid; 0.5, 1, 2, 4, or 6 hours pre-acetic acid); p.o. (60 min pre-acetic acid)
Result:

Produced dose-dependent inhibition of acetic acid-induced abdominal constrictions, with an ID₅₀ of 5.6 mg/kg (i.p.) and 147.3 mg/kg (p.o.), achieving maximum inhibitions of 83% and 57%, respectively.
Produced significant antinociception starting at 30 minutes post-administration with 10 mg/kg i.p., which persisted for up to 4 hours.
Had its antinociceptive effect completely reversed by pre-treatment with L-arginine (600 mg/kg i.p.), naloxone (1 mg/kg i.p.), yohimbine (0.15 mg/kg i.p.), ketanserin (0.3 mg/kg i.p.), ondansetron (0.5 mg/kg i.p.), or efaroxan (1 mg/kg i.p.), but not by D-arginine (600 mg/kg i.p.), pindolol (1 mg/kg i.p.), idazoxan (3 mg/kg i.p.), or neonatal capsaicin treatment.
Had its antinociceptive effect significantly reversed by pre-treatment with p-chlorophenylalanine methyl ester (100 mg/kg i.p. once daily for 4 days).

Animal Model:

Swiss mice (both sexes, 25-35 g)^[2]
Dosage:

10-100 mg/kg
Administration:

i.p. (30 min pre-glutamate)
Result:

Produced dose-dependent inhibition of glutamate-induced paw licking, with an ID₅₀ of 19.5 mg/kg and a maximum inhibition of 76%.

Animal Model:

Swiss mice (both sexes, 25-35 g)^[2]
Dosage:

3-100 mg/kg
Administration:

i.p. (30 min pre-capsaicin)
Result:

Produced dose-dependent inhibition of capsaicin-induced paw licking, with an ID₅₀ of 43.7 mg/kg and a maximum inhibition of 55%.

Animal Model:

Swiss mice (both sexes, 25-35 g)^[2]
Dosage:

1-100 mg/kg (30 min pre-formalin); 10 mg/kg (10 min pre-formalin); 10 mg/kg (5 min post-formalin)
Administration:

i.p. (30 min pre-formalin; 10 min pre-formalin; 5 min post-formalin)
Result:

Produced dose-dependent inhibition of both formalin-induced pain phases, with ID₅₀ values of 13.7 mg/kg (neurogenic phase, maximum inhibition 65%) and 5.6 mg/kg (inflammatory phase, maximum inhibition 76%).
Inhibited the neurogenic phase significantly when administered 10 mg/kg i.p. 10 minutes pre-formalin.
Inhibited the inflammatory phase by 42% when administered 10 mg/kg i.p. 5 minutes post-formalin.
Inhibited the inflammatory phase by 56% when administered 10 mg/kg i.p. 30 minutes pre-formalin.

Chemical Information

CAS No. 306-60-5
Appearance Solid
분자량 130.19
화학식 C₅H₁₄N₄
Color White to off-white
SMILES

NC(NCCCCN)=N
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Psychopharmacology (Berl)

Agmatine ameliorates morphine-induced behavioral sensitization through blood-brain barrier protection and anti-neuroinflammatory effects in the nucleus accumbens. [Abstract]

2025 Oct 24. PMID: 41134339

순도&문서

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nudelman N. Aromatic nucleophilic substitution in aprotic solvents using hydrogen-bonded biological amines. Kinetic studies and quantum chemical calculations[J]. Journal of Physical Organic Chemistry, 2015.

[2]. Santos AR, et al. Mechanisms involved in the antinociception caused by agmatine in mice. Neuropharmacology. 2005;48(7):1021-1034. [Content Brief]

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (1)
순도&문서
References

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Agmatine

Publications Citing Use of MedChemExpress (MCE) Agmatine

All 5-HT Receptor Isoforms

All Adrenergic Receptor Isoforms