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Cat. No.: HY-152774

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Antitumor agent-86

Antitumor agent-86 (compound 5a) inhibits MCF-7 breast cancer cells with an IC₅₀ value of 2.62 µM. Antitumor agent-86 induces cell apoptosis and cell cycle arrest, and shows antineoplastic activity by targeting RAS/PI3K/Akt/JNK signaling cascades.

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CAS No.: 2907704-65-6
화학식: C₂₉H₃₁N₅O₂S
분자량:513.65

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Antitumor agent-86 Chemical Structure

CAS No.: 2907704-65-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Akt Isoforms :

All PI3K Isoforms :

In Vitro

Antitumor agent-86 (0-200 μM; 48 h) dose-dependently suppresses MCF-7, MDA-MB-231, Caco-2, and PANC-1 cancer cell proliferation with IC₅₀ values of 2.617, 6.778, 14.8 and 23.58 µM, respectively^[1].
Antitumor agent-86 (2.62 μM; 48 h) induces cell apoptosis, cell cycle arrest and decreases the levels of p-RAS proteins, mRNA transcript level of PI3K and Akt and p-JNK protein expression of MCF-7 cells^[1].
Antitumor agent-86 (2.62 μM; 48 h) up-regulates p21 gene expression level^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MCF-7, MDA-MB-231, Caco-2 and PANC-1 cell lines
Concentration:

0-200 μM
Incubation Time:

48 hours
Result:

Dose-dependently suppressed cell proliferation of human cancer cell lines.

Western Blot Analysis^[1]

Cell Line:

MCF-7 cell line
Concentration:

2.62 μM
Incubation Time:

48 hours
Result:

Decreased levels of p-JNK and p-RAS in MCF-7 cells.

Apoptosis Analysis^[1]

Cell Line:

MCF-7 cell line
Concentration:

2.62 μM
Incubation Time:

48 hours
Result:

Induced cell apoptosis with morphological changess such as cell rounding and shrinkage with decreased cell number detachment and cytoplasmic condensation.

Chemical Information

CAS No. 2907704-65-6
분자량 513.65
화학식 C₂₉H₃₁N₅O₂S
SMILES

COC1=CC(C2CC(C3=C(NC(NC3C4=CC=C(C=C4)N(C)C)=S)C)=NN2C5=CC=CC=C5)=CC=C1O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Salem MM, et al. Synthesis, molecular docking, and in-vitro studies of pyrimidine-2-thione derivatives as antineoplastic agents via potential RAS/PI3K/Akt/JNK inhibition in breast carcinoma cells. Sci Rep. 2022 Dec 22;12(1):22146. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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Antitumor agent-86

All Akt Isoforms

All PI3K Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Antitumor agent-86 Related Classifications

HY-152774 Related Classifications