AS19
Based on 1 publication(s) in Google Scholar
AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia.
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- Purity: 99.69%
- CAS No.: 1000578-26-6
- 화학식: C18H25N3
- 분자량:283.41
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보관:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Publications Citing Use of MedChemExpress (MCE) AS19
MoreAll 5-HT Receptor Isoforms
More
Biological Activity
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5-HT1A Receptor |
5-HT1B Receptor |
5-HT1D Receptor |
5-HT5A Receptor |
5-HT7 Receptor |
Human 5-HT7 Receptor 0.83 nM (IC50) |
Human 5-HT7 Receptor 0.6 nM (Ki) |
5-HT1A Receptor 89.7 nM (Ki) |
5-HT1B Receptor 490 nM (Ki) |
5-HT1D Receptor 6.6 nM (Ki) |
5-HT5 Receptor 98.5 nM (Ki) |
The proliferation of T-cell from parachlorophenylalanine-treated mice is significantly reduced, addition of AS19 (1 μM) completely restores T-cell proliferation after 48 hours[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (12-week-old) with autoshaping Pavlovian/instrumental learning task[1]
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Dosage:0.5 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg
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Administration:Subcutaneous injection; for 24 hours
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Result:Enhanced memory formation in an autoshaping Pavlovian/instrumental learning task.
Chemical Information
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CAS No. 1000578-26-6
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Appearance Oil
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분자량 283.41
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화학식 C18H25N3
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Color Light yellow to brown
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SMILES
CC1=C(C2=CC=CC3=C2CC[C@H](N(C)C)C3)C(C)=NN1C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Metab
Serotonin-licensed macrophages potentiate chemoresistance via inositol metabolic crosstalk in ovarian cancer. [Abstract]2025 Dec 17:S1550-4131(25)00495-4. PMID: 41412121
용액&용해도
DMSO : 100 mg/mL (352.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.82 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.82 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Perez-García GS, et al. Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav Brain Res. 2005 Aug 30;163(1):136-40. [Content Brief]
[2]. León-Ponte M, et al. Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor. Blood. 2007 Apr 15;109(8):3139-46. [Content Brief]
[3]. Brenchat A, et al. 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice. Pain. 2009 Feb;141(3):239-47. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5285 mL | 17.6423 mL | 35.2846 mL | 88.2114 mL |
| 5 mM | 0.7057 mL | 3.5285 mL | 7.0569 mL | 17.6423 mL | |
| 10 mM | 0.3528 mL | 1.7642 mL | 3.5285 mL | 8.8211 mL | |
| 15 mM | 0.2352 mL | 1.1762 mL | 2.3523 mL | 5.8808 mL | |
| 20 mM | 0.1764 mL | 0.8821 mL | 1.7642 mL | 4.4106 mL | |
| 25 mM | 0.1411 mL | 0.7057 mL | 1.4114 mL | 3.5285 mL | |
| 30 mM | 0.1176 mL | 0.5881 mL | 1.1762 mL | 2.9404 mL | |
| 40 mM | 0.0882 mL | 0.4411 mL | 0.8821 mL | 2.2053 mL | |
| 50 mM | 0.0706 mL | 0.3528 mL | 0.7057 mL | 1.7642 mL | |
| 60 mM | 0.0588 mL | 0.2940 mL | 0.5881 mL | 1.4702 mL | |
| 80 mM | 0.0441 mL | 0.2205 mL | 0.4411 mL | 1.1026 mL | |
| 100 mM | 0.0353 mL | 0.1764 mL | 0.3528 mL | 0.8821 mL |
AS19 Related Classifications
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