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Cat. No.: HY-110218

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CW 008

2 Cited Publications

고객리뷰

Based on 2 publication(s) in Google Scholar

CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.15%
CAS No.: 1134613-19-6
화학식: C₂₁H₁₄F₂N₆O₂
분자량:420.37

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

CW 008 Chemical Structure

CAS No.: 1134613-19-6

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
Publications (2)
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

PKA

All PKA Isoforms :

All Epigenetic Reader Domain Isoforms :

Chemical Information

CAS No. 1134613-19-6
Appearance Solid
분자량 420.37
화학식 C₂₁H₁₄F₂N₆O₂
Color White to yellow
SMILES

O=C(C1=CC=C(C=C1)F)NC2=NNC3=C2C=C(F)C(C4=C5C=C(OC)C=CN5N=C4)=N3
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Cell Metab

Gut microbiota-derived isovaleric acid alleviates atrial fibrillation by suppressing GSDME-dependent pyroptosis. [Abstract]

2026 Feb 3;38(2):370-387.e10. PMID: 41638192
Mol Carcinog

Adipocytes Promote Endometrial Cancer Progression Through Activation of the SIRT1-HMMR Signaling Axis. [Abstract]

2024 Dec;63(12):2363-2381. PMID: 39254492

용액&용해도

In Vitro:

DMSO : 16.67 mg/mL (39.66 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3789 mL

11.8943 mL

23.7886 mL

5 mM

0.4758 mL

2.3789 mL

4.7577 mL

10 mM

0.2379 mL

1.1894 mL

2.3789 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nooshin AMINI, et al. Methods and compositions for generating human forebrain neural progenitor cells and for maturation thereof to parvalbumin+ interneurons. Patent, WO2023075913A1.

[2]. Patrick Soon-Shiong. Patient treatment via teratogenic pharmaceutical compounds. Patent, WO2016176675A2.

[3]. Kim JM, et al. An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells. J Cell Physiol. 2013 Mar;228(3):617-26. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3789 mL	11.8943 mL	23.7886 mL	59.4714 mL
	5 mM	0.4758 mL	2.3789 mL	4.7577 mL	11.8943 mL
	10 mM	0.2379 mL	1.1894 mL	2.3789 mL	5.9471 mL
	15 mM	0.1586 mL	0.7930 mL	1.5859 mL	3.9648 mL
	20 mM	0.1189 mL	0.5947 mL	1.1894 mL	2.9736 mL
	25 mM	0.0952 mL	0.4758 mL	0.9515 mL	2.3789 mL
	30 mM	0.0793 mL	0.3965 mL	0.7930 mL	1.9824 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
Publications (2)
용액&용해도
- In Vitro
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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Purity:
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CW 008

Epigenetics Compound Library

Stem Cell Signaling Compound Library

TGF-beta/Smad Compound Library

Histone Modification Research Compound Library

Anti-Aging Compound Library

Reprogramming Compound Library

Anti-Blood Cancer Compound Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

Anti-Prostate Cancer Compound Library

Osteogenesis Compound Library

Pain-Related Compound Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) CW 008

All PKA Isoforms

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Publications (2)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

CW 008

Epigenetics Compound Library

Stem Cell Signaling Compound Library

TGF-beta/Smad Compound Library

Histone Modification Research Compound Library

Anti-Aging Compound Library

Reprogramming Compound Library

Anti-Blood Cancer Compound Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

Anti-Prostate Cancer Compound Library

Osteogenesis Compound Library

Pain-Related Compound Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) CW 008

All PKA Isoforms

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Publications (2)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

CW 008 Related Classifications

HY-110218 Related Classifications