Cat. No.: HY-100712

DPO-1

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

DPO-1 is a potent Kv1.5 and Kv1.3 (EC₅₀ = 3.1 μM) channels inhibitor with potential immunomodulatory and anti-inflammatory effects. DPO-1 reduces Kv1.3 current density, blunts Ca²⁺ influx in Ca²⁺-depleted Jurkat cells, and inhibits IL-2 secretion in activated Jurkat cells. DPO-1 inhibits Uric acid sodium (HY-B2130A) (MSU)-induced NLRP3 inflammasome activation by blocking Kv1.5-mediated K⁺ efflux. DPO-1 can be used for the study of immunologic disorders and atrial fibrillation.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.39%
CAS No.: 43077-30-1
화학식: C₂₂H₂₉OP
분자량:340.44

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

DPO-1 Chemical Structure

CAS No.: 43077-30-1

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Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Calcium Channel Isoforms :

All NOD-like Receptor (NLR) Isoforms :

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	30 nM Compound: 1, DPO-1	Inhibition of human Kv1.5 channel expressed in CHO cells by whole cell patch clamp assay Inhibition of human Kv1.5 channel expressed in CHO cells by whole cell patch clamp assay	[PMID: 20304642]

In Vitro

DPO-1 (1-10 μM) inhibits outward K⁺ currents in mesenteric artery VSMCs from wild-type (Kcna5^+/+) mice, with a more potent inhibitory effect than in VSMCs from Kcna5^-/- mice^[1].
DPO-1 (10 μM, 30 min) induces stable vasocontraction in mesenteric artery rings without PVAT in Kcna5^+/+ and Kcna5^-/- mice^[1].
DPO-1 (0.3-30 μM) blocks Kv1.3 current in a voltage-dependent and concentration-dependent manner in Jurkat cells and human peripheral blood T cells, with IC₅₀ values of 2.58 μM (Jurkat cells) and 3.11 μM (human peripheral blood T cells)^[2].
DPO-1 (1-10 μM, 24 h) decreases Kv1.3 current density at +40 mV in Jurkat cells and reduces Kv1.3 protein expression^[2].
DPO-1 (0.1-3 μM, 24 h) blunts Ca²⁺ influx in Ca²⁺-depleted Jurkat cells induced by Thapsigargin (TG) (HY-13433)^[2].
DPO-1 (3-10 μM, 24 h) inhibits IL-2 secretion in activated Jurkat cells^[2].
DPO-1 (0-100 μM, 6 h) concentration-dependently reduces caspase-1 (p20) and IL-1β (p17) protein levels, prevents intracellular K⁺ concentration decrease, suppresses ASC oligomerization and speck formation in LPS (HY-D1056)-primed J774.1 mouse macrophages^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 43077-30-1
Appearance Solid
분자량 340.44
화학식 C₂₂H₂₉OP
Color White to off-white
SMILES

CC([C@H]1[C@@H](P(C2=CC=CC=C2)(C3=CC=CC=C3)=O)C[C@H](C)CC1)C
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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2025 Nov 12.

용액&용해도

In Vitro:

DMSO : 10 mg/mL (29.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9374 mL

14.6869 mL

29.3738 mL

5 mM

0.5875 mL

2.9374 mL

5.8748 mL

10 mM

0.2937 mL

1.4687 mL

2.9374 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tsvetkov D, et al. The Role of DPO-1 and XE991-Sensitive Potassium Channels in Perivascular Adipose Tissue-Mediated Regulation of Vascular Tone. Front Physiol. 2016 Aug 4;7:335. [Content Brief]

[2]. Zhao N, et al. Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells. PLoS One. 2013 May 22;8(5):e64629. [Content Brief]

[3]. Li P, et al. Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes. Mol Biol Rep. 2022 Jul;49(7):5939-5952. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9374 mL	14.6869 mL	29.3738 mL	73.4344 mL
	5 mM	0.5875 mL	2.9374 mL	5.8748 mL	14.6869 mL
	10 mM	0.2937 mL	1.4687 mL	2.9374 mL	7.3434 mL
	15 mM	0.1958 mL	0.9791 mL	1.9583 mL	4.8956 mL
	20 mM	0.1469 mL	0.7343 mL	1.4687 mL	3.6717 mL
	25 mM	0.1175 mL	0.5875 mL	1.1750 mL	2.9374 mL

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DPO-1

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Publications Citing Use of MedChemExpress (MCE) DPO-1

All Calcium Channel Isoforms

All NOD-like Receptor (NLR) Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Publications (1)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

DPO-1 Related Classifications

HY-100712 Related Classifications